Results 21 to 30 of about 163,677 (304)

mGlu5 inhibition in the basolateral amygdala prevents estrous cycle-dependent changes in cue-induced cocaine seeking

Addiction Neuroscience, 2023
Drug associated cues are a common relapse trigger for individuals recovering from cocaine use disorder. Sex and ovarian hormones influence patterns of cocaine use and relapse vulnerability, with studies indicating that females show increased cue-induced ...
Claire M. Corbett, Emily N.D. Miller, Jessica A. Loweth   +2 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: Pharmacological and behavioral genetics evidence

Frontiers in Behavioral Neuroscience, 2012
Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Jonathan eHollander, Don ePham, Christie eFowler, Paul J Kenny   +3 more
doaj   +1 more source

Effects of Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 on the Reinstatement of Cocaine-Mediated Conditioned Place Preference in Mice

Frontiers in Behavioral Neuroscience, 2022
A high percentage of relapse to compulsive cocaine-taking and cocaine-seeking behaviors following abstinence constitutes a major obstacle to the clinical treatment of cocaine addiction.
Changliang Zhu, Changliang Zhu, Lei Wang, Jiangwei Ding, Hailiang Li, Hailiang Li, Din Wan, Yangyang Sun, Baorui Guo, Zhenquan He, Xiaofan Ren, Shucai Jiang, Shucai Jiang, Caibing Gao, Caibing Gao, Hua Guo, Tao Sun, Tao Sun, Feng Wang, Feng Wang   +19 more
doaj   +1 more source

Dissociation Between Incubation of Cocaine Craving and Anxiety-Related Behaviors After Continuous and Intermittent Access Self-Administration

Frontiers in Neuroscience, 2022
Studies using either continuous or intermittent access cocaine self-administration procedures showed that cocaine seeking increases during abstinence (incubation of cocaine craving), and that this effect is higher after intermittent cocaine access. Other
Celine Nicolas, Trinity I. Russell, Yavin Shaham, Satoshi Ikemoto   +3 more
doaj   +1 more source

"EFFECT OF APAMIN ON TOLERANCE TO COCAINE-INDUCED LOCOMOTOR ACTIVITY IN MICE" [PDF]

Acta Medica Iranica, 2004
In the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated.
H. R. Jamshidi, M. Rezayat M. R. Zarrindast   +1 more
doaj   +1 more source

Can ropinirole modulate reinforcing subjective effects of cocaine in humans?

Frontiers in Psychiatry, 2011
In this study we evaluated, by means of the Cocaine Rush Visual Analogue Scale (CRVAS), the impact of ropinirole on the expected rush induced by cocaine in a group of heroin addicts abusing cocaine; the self-reported reaction to the rush blockade (if ...
Angelo Giovanni Icro eMaremmani, Angelo Giovanni Icro eMaremmani, Matteo ePacini, Luca eRovai, Fabio eRugani, Liliana eDell'Osso, Icro eMaremmani, Icro eMaremmani, Icro eMaremmani   +8 more
doaj   +1 more source

Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. [PDF]

PLoS ONE, 2013
The activation of dopamine receptors within the mesolimbic dopamine system is known to be involved in the initiation and maintenance of cocaine use. Expression of the D2 dopamine receptor subtype has been implicated as both a predisposing factor and ...
Kathryn E Merritt, Ryan K Bachtell
doaj   +1 more source

Human Carboxylesterase 2 in Cocaine Metabolism [PDF]

, 2021
Increased hydrolysis of cocaine to non-toxic compounds is a promising way to prevent cocaine-induced toxicity. However, the short half-life of cocaine in the blood and the rapid conversion in the body to the hydrolysis-resistant metabolite ...
Alexandra T.P., Carvalho, Pedro R., Figueiredo, Ricardo D., González   +2 more
core   +1 more source

Associations amongst form of cocaine used (powder vs crack vs both) and HIV-related outcomes

Addictive Behaviors Reports, 2021
Introduction: Cocaine (including powder and crack) use is common among people with HIV (PWH). We identified socio-demographic and behavioral factors associated with cocaine use (overall and various forms) among PWH; we also examined differences in HIV ...
Yiyang Liu, Veronica L. Richards, Nioud Mulugeta Gebru, Emma C. Spencer, Robert L. Cook   +4 more
doaj   +1 more source