Results 21 to 30 of about 309,381 (308)

Environmental enrichment facilitates cocaine-cue extinction, deters reacquisition of cocaine self-administration and alters AMPAR GluA1 expression and phosphorylation [PDF]

, 2015
This study investigated the combination of environmental enrichment (EE) with cocaine‐cue extinction training on reacquisition of cocaine self‐administration.
Dhonnchadha, Brid Aine Nic, Gauthier, Jamie M., Kantak, Kathleen M., Lin, Amy, Man, Heng-Ye, Spealman, Roger D.   +5 more
core   +1 more source

Mandatory Minimum Sentencing Policies and Cocaine Use in the U.S., 1985–2013 [PDF]

, 2018
Background: As of May 2017, the United States federal government renewed its prioritization for the enforcement of mandatory minimum sentences for illicit drug offenses.
Mezuk, Briana, Walker, Lauryn Saxe
core   +2 more sources

Stressor- and Corticotropin releasing Factor-induced Reinstatement and Active Stress-related Behavioral Responses are Augmented Following Long-access Cocaine Self-administration by Rats [PDF]

, 2008
Rationale Stressful events during periods of drug abstinence likely contribute to relapse in cocaine-dependent individuals. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing
AM Basso, B Costall, B Costall, B Lee, B Wang, B Wang, BA Sorg, BA Sorg, CJ Sanchez, David A. Baker, David M. Francis, DJ Lodge, EB Souza De, EP Zorrilla, Eric S. Katz, G Paxinos, HC Fox, J Liu, John R. Mantsch, Joseph P. Serge, JR Mantsch, JR Mantsch, K McFarland, L Lu, L Lu, LJMJ Vanderschuren, LM Najavits, LW Swanson, MA Sutton, MA Ungless, Michael A. Hoks, N Capriles, NE Goeders, NE Goeders, NH Mutschler, PW Kalivas, PW Kalivas, R Sinha, R Sinha, RA Fuchs, RE Sorge, RM Richter, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Pellow, S Pollandt, SH Ahmed, SH Ahmed, SH Ahmed, SH Ahmed, TE Kippin, TM Korotkova, V Deroche-Gamonet, Y Shaham, Y Zhou, Z Sarnyai, Z Sarnyai   +62 more
core   +2 more sources

Deletion of the GABAA α2-subunit does not alter self dministration of cocaine or reinstatement of cocaine seeking [PDF]

, 2014
Rationale GABAA receptors containing α2-subunits are highly represented in brain areas that are involved in motivation and reward, and have been associated with addiction to several drugs, including cocaine.
A Agrawal, AC Barrett, B. Halbout, C Schwarzer, C. I. Dixon, CI Dixon, CI Dixon, CI Dixon, D. N. Stephens, DM Dick, DM Thompson, EM Weerts, G Brown, HC Fox, HJ Edenberg, HN Katz, HV Morris, HV Morris, J Covault, J Merrer Le, JD Salamone, JR Taylor, K Low, KL Conrad, LA Knackstedt, LJ Herberg, LM Reynolds, LO Bauer, M Filip, M Filip, MA Enoch, MA Enoch, MJ Thomas, ND Volkow, P Waelti, PA Broderick, PA Lind, R Keiflin, R Sinha, RA Wise, RW Keller Jr, S Erb, S Pirker, S Taverna, S Villafuerte, S. L. King, SA Kushner, SH Ahmed, SL Dewey, SS Negus, TE Robinson, TW Robbins, TW Robbins, TW Robbins, W Schultz, Y Kawaguchi   +55 more
core   +1 more source

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]

, 2015
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M., Dwoskin, Linda P., Jeon, Sae-Mi, Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +5 more
core   +1 more source

Cocaine adulteration

Journal of Chemical Neuroanatomy, 2017
Cocaine is a naturally occurring and illicitly used psychostimulant drug. Cocaine acts at monoaminergic neurotransmitter transporters to block uptake of the monoamines, dopamine, serotonin and norepinephrine. The resulting increase of monoamines in the extracellular space underlies the positively reinforcing effects that cocaine users seek.
Oliver, Kudlacek, Tina, Hofmaier, Anton, Luf, Felix P, Mayer, Thomas, Stockner, Constanze, Nagy, Marion, Holy, Michael, Freissmuth, Rainer, Schmid, Harald H, Sitte   +9 more
openaire   +3 more sources

Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release. [PDF]

PLoS ONE, 2008
Intravenous injections of cocaine HCl are habit-forming because, among their many actions, they elevate extracellular dopamine levels in the terminal fields of the mesocorticolimbic dopamine system. This action, thought to be very important for cocaine's
Roy A Wise, Bin Wang, Zhi-Bing You
doaj   +1 more source

Effects of Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 on the Reinstatement of Cocaine-Mediated Conditioned Place Preference in Mice

Frontiers in Behavioral Neuroscience, 2022
A high percentage of relapse to compulsive cocaine-taking and cocaine-seeking behaviors following abstinence constitutes a major obstacle to the clinical treatment of cocaine addiction.
Changliang Zhu, Changliang Zhu, Lei Wang, Jiangwei Ding, Hailiang Li, Hailiang Li, Din Wan, Yangyang Sun, Baorui Guo, Zhenquan He, Xiaofan Ren, Shucai Jiang, Shucai Jiang, Caibing Gao, Caibing Gao, Hua Guo, Tao Sun, Tao Sun, Feng Wang, Feng Wang   +19 more
doaj   +1 more source

Differential Regulation of the Period Genes in Striatal Regions following Cocaine Exposure [PDF]

, 2013
Several studies have suggested that disruptions in circadian rhythms contribute to the pathophysiology of multiple psychiatric diseases, including drug addiction.
AEK Kosobud, Angela Ozburn, B Halbout, BJ Everitt, BT Hope, C Abarca, C Crosio, CA McClung, CH Ko, Colleen A. McClung, DP King, E Harms, Edgardo Falcon, EJ Nestler, EJ Nestler, EM Jones, ES Maywood, EW Lamont, FK Stephan, H Manev, JA Garcia, JA Wasielewski, JF Enwright, K Bae, Kole Roybal, LP Shearman, M Iijima, M Imbesi, M Reick, N Gekakis, R Andretic, R Spanagel, RA Wise, S Masubuchi, S Perreau-Lenz, Shibani Mukherjee, T Nikaido, T Zghoul, V Yuferov, V Yuferov, WJ Lynch, Xiaoxi Zhuang, Y Liu, Y Liu, YD Zhou, Z Travnickova-Bendova   +45 more
core   +2 more sources

Dissociation Between Incubation of Cocaine Craving and Anxiety-Related Behaviors After Continuous and Intermittent Access Self-Administration

Frontiers in Neuroscience, 2022
Studies using either continuous or intermittent access cocaine self-administration procedures showed that cocaine seeking increases during abstinence (incubation of cocaine craving), and that this effect is higher after intermittent cocaine access. Other
Celine Nicolas, Trinity I. Russell, Yavin Shaham, Satoshi Ikemoto   +3 more
doaj   +1 more source