Results 21 to 30 of about 112,229 (260)
Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release. [PDF]
PLoS ONE, 2008 Intravenous injections of cocaine HCl are habit-forming because, among their many actions, they elevate extracellular dopamine levels in the terminal fields of the mesocorticolimbic dopamine system. This action, thought to be very important for cocaine's
Roy A Wise, Bin Wang, Zhi-Bing You
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Frontiers in Behavioral Neuroscience, 2022 A high percentage of relapse to compulsive cocaine-taking and cocaine-seeking behaviors following abstinence constitutes a major obstacle to the clinical treatment of cocaine addiction.
Changliang Zhu +19 more
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"EFFECT OF APAMIN ON TOLERANCE TO COCAINE-INDUCED LOCOMOTOR ACTIVITY IN MICE" [PDF]
Acta Medica Iranica, 2004 In the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated.
H. R. Jamshidi +1 more
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Frontiers in Neuroscience, 2022 Studies using either continuous or intermittent access cocaine self-administration procedures showed that cocaine seeking increases during abstinence (incubation of cocaine craving), and that this effect is higher after intermittent cocaine access. Other
Celine Nicolas +3 more
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Can ropinirole modulate reinforcing subjective effects of cocaine in humans?
Frontiers in Psychiatry, 2011 In this study we evaluated, by means of the Cocaine Rush Visual Analogue Scale (CRVAS), the impact of ropinirole on the expected rush induced by cocaine in a group of heroin addicts abusing cocaine; the self-reported reaction to the rush blockade (if ...
Angelo Giovanni Icro eMaremmani +8 more
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Conditioned Contribution of Peripheral Cocaine Actions to Cocaine Reward and Cocaine-Seeking [PDF]
Neuropsychopharmacology, 2013 Cocaine has actions in the peripheral nervous system that reliably precede--and thus predict--its soon-to-follow central rewarding effects. In cocaine-experienced animals, the peripheral cocaine signal is relayed to the central nervous system, triggering excitatory input to the ventral tegmental origin of the mesocorticolimbic dopamine system, the ...
Bin, Wang +5 more
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Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. [PDF]
PLoS ONE, 2013 The activation of dopamine receptors within the mesolimbic dopamine system is known to be involved in the initiation and maintenance of cocaine use. Expression of the D2 dopamine receptor subtype has been implicated as both a predisposing factor and ...
Kathryn E Merritt, Ryan K Bachtell
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Associations amongst form of cocaine used (powder vs crack vs both) and HIV-related outcomes
Addictive Behaviors Reports, 2021 Introduction: Cocaine (including powder and crack) use is common among people with HIV (PWH). We identified socio-demographic and behavioral factors associated with cocaine use (overall and various forms) among PWH; we also examined differences in HIV ...
Yiyang Liu +4 more
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Silent Cocaine Poisoning [PDF]
Asia Pacific Journal of Medical Toxicology, 2014 Background: Cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. Absence of clinical manifestations in cocaine poisoning is unusual.
Rachid El-Jaoudi +5 more
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Addiction Neuroscience, 2023 The hypocretins/orexins (HCRT) have been demonstrated to influence motivation for cocaine through actions on dopamine (DA) transmission. Pharmacological or genetic disruption of the hypocretin receptor 1 (Hcrtr1) reduces cocaine self-administration ...
Emily M. Black +6 more
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