Results 21 to 30 of about 160,082 (298)

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: Pharmacological and behavioral genetics evidence

Frontiers in Behavioral Neuroscience, 2012
Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Jonathan eHollander, Don ePham, Christie eFowler, Paul J Kenny   +3 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Matrix‐Activated Aptamer Sensors for Human Serum Analysis

Angewandte Chemie, EarlyView.
The sample self‐analyzes: The predominant serum proteins, albumin and immunoglobulin G, were leveraged to activate the response of fluorescent aptamer probes within the biological matrix. The fluorescence‐anisotropy‐based sensing platform demonstrated both performance and consistency for the direct detection of small molecules in serum‐rich samples ...
Amandine Barbaroux, Benoit Chovelon, Emmanuelle Fiore, Sebastien Vezirian, Mickael Henry, Marwa Zoubeidi, Maria C. DeRosa, Corinne Ravelet, Eric Peyrin   +8 more
wiley   +2 more sources

Effects of Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 on the Reinstatement of Cocaine-Mediated Conditioned Place Preference in Mice

Frontiers in Behavioral Neuroscience, 2022
A high percentage of relapse to compulsive cocaine-taking and cocaine-seeking behaviors following abstinence constitutes a major obstacle to the clinical treatment of cocaine addiction.
Changliang Zhu, Changliang Zhu, Lei Wang, Jiangwei Ding, Hailiang Li, Hailiang Li, Din Wan, Yangyang Sun, Baorui Guo, Zhenquan He, Xiaofan Ren, Shucai Jiang, Shucai Jiang, Caibing Gao, Caibing Gao, Hua Guo, Tao Sun, Tao Sun, Feng Wang, Feng Wang   +19 more
doaj   +1 more source

"EFFECT OF APAMIN ON TOLERANCE TO COCAINE-INDUCED LOCOMOTOR ACTIVITY IN MICE" [PDF]

Acta Medica Iranica, 2004
In the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated.
H. R. Jamshidi, M. Rezayat M. R. Zarrindast   +1 more
doaj   +1 more source

Cocaine serves as a peripheral interoceptive conditioned stimulus for central glutamate and dopamine release. [PDF]

PLoS ONE, 2008
Intravenous injections of cocaine HCl are habit-forming because, among their many actions, they elevate extracellular dopamine levels in the terminal fields of the mesocorticolimbic dopamine system. This action, thought to be very important for cocaine's
Roy A Wise, Bin Wang, Zhi-Bing You
doaj   +1 more source

Dissociation Between Incubation of Cocaine Craving and Anxiety-Related Behaviors After Continuous and Intermittent Access Self-Administration

Frontiers in Neuroscience, 2022
Studies using either continuous or intermittent access cocaine self-administration procedures showed that cocaine seeking increases during abstinence (incubation of cocaine craving), and that this effect is higher after intermittent cocaine access. Other
Celine Nicolas, Trinity I. Russell, Yavin Shaham, Satoshi Ikemoto   +3 more
doaj   +1 more source

Let it snow! let it snow! let it snow! Estimating cocaine production using a novel dataset based on reported seizures of laboratories [PDF]

, 2012
BackgroundData on the cocaine market appear inconsistent, as they tend to show declining prices vis-a-vis steady or increasing demand and a declining supply.
Rentocchini, Francesco, Riccardo Leoncini, Francesco Rentocchini, R. Leoncini, Leoncini, Riccardo, F. Rentocchini   +5 more
core   +1 more source

Incubation of cocaine craving coincides with changes in dopamine terminal neurotransmission

Addiction Neuroscience, 2022
Relapse to drug use is one of the major challenges in treating substance use disorders. Exposure to drug-related cues and contexts triggers drug craving, which drives cocaine seeking, and increases the probability of relapse.
I. Pamela Alonso, Bethan M. O'Connor, Kathleen G. Bryant, Rushi K. Mandalaywala, Rodrigo A. España   +4 more
doaj   +1 more source

Can ropinirole modulate reinforcing subjective effects of cocaine in humans?

Frontiers in Psychiatry, 2011
In this study we evaluated, by means of the Cocaine Rush Visual Analogue Scale (CRVAS), the impact of ropinirole on the expected rush induced by cocaine in a group of heroin addicts abusing cocaine; the self-reported reaction to the rush blockade (if ...
Angelo Giovanni Icro eMaremmani, Angelo Giovanni Icro eMaremmani, Matteo ePacini, Luca eRovai, Fabio eRugani, Liliana eDell'Osso, Icro eMaremmani, Icro eMaremmani, Icro eMaremmani   +8 more
doaj   +1 more source