Results 21 to 30 of about 188,136 (212)

Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins. [PDF]

PLoS ONE, 2014
Cocaine exposure during gestation causes protracted neurobehavioral changes consistent with a compromised glutamatergic system. Although cocaine profoundly disrupts glutamatergic neurotransmission and in utero cocaine exposure negatively affects ...
Kalindi Bakshi, Raminder Parihar, Satindra K Goswami, Melissa Walsh, Eitan Friedman, Hoau-Yan Wang   +5 more
doaj   +1 more source

mGlu5 inhibition in the basolateral amygdala prevents estrous cycle-dependent changes in cue-induced cocaine seeking

Addiction Neuroscience, 2023
Drug associated cues are a common relapse trigger for individuals recovering from cocaine use disorder. Sex and ovarian hormones influence patterns of cocaine use and relapse vulnerability, with studies indicating that females show increased cue-induced ...
Claire M. Corbett, Emily N.D. Miller, Jessica A. Loweth   +2 more
doaj   +1 more source

The treatment of cocaine use disorder

Science Advances, 2019
Current treatments for cocaine use disorder are often ineffective; new treatments are needed and are under development. Cocaine use continues to be a serious worldwide public health problem.
K. Kampman
semanticscholar   +1 more source

Dopaminergic dynamics underlying sex-specific cocaine reward

Nature Communications, 2017
Although both males and females become addicted to cocaine, females transition to addiction faster and experience greater difficulties remaining abstinent.
E. Calipari, B. Juarez, Carole Morel, D. Walker, M. Cahill, Efrain A. Ribeiro, Ciorana Roman-Ortiz, C. Ramakrishnan, K. Deisseroth, Ming-Hu Han, E. Nestler   +10 more
semanticscholar   +1 more source

Conditioned Contribution of Peripheral Cocaine Actions to Cocaine Reward and Cocaine-Seeking [PDF]

Neuropsychopharmacology, 2013
Cocaine has actions in the peripheral nervous system that reliably precede--and thus predict--its soon-to-follow central rewarding effects. In cocaine-experienced animals, the peripheral cocaine signal is relayed to the central nervous system, triggering excitatory input to the ventral tegmental origin of the mesocorticolimbic dopamine system, the ...
Bin, Wang, Zhi-Bing, You, Erik B, Oleson, Joseph F, Cheer, Stephanie, Myal, Roy A, Wise   +5 more
openaire   +2 more sources

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: Pharmacological and behavioral genetics evidence

Frontiers in Behavioral Neuroscience, 2012
Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Jonathan eHollander, Don ePham, Christie eFowler, Paul J Kenny   +3 more
doaj   +1 more source

Acute and Chronic Effects of Cocaine on Cardiovascular Health

International Journal of Molecular Sciences, 2019
Cardiac complications resulting from cocaine use have been extensively studied because of the complicated pathophysiological mechanisms. This study aims to review the underlying cellular and molecular mechanisms of acute and chronic effects of cocaine on
Sung Tae Kim, T. Park
semanticscholar   +1 more source

Incubation of cocaine craving after intermittent access self-administration: sex differences and estrous cycle

Biological Psychiatry, 2019
BACKGROUND: Studies using continuous access drug self-administration showed that cocaine seeking increases during abstinence (incubation of cocaine craving).
C. Nicolas, Trinity I. Russell, Anne F. Pierce, Steeve Maldera, A. Holley, Zhi-bing You, M. McCarthy, Y. Shaham, S. Ikemoto   +8 more
semanticscholar   +1 more source

Effects of Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 on the Reinstatement of Cocaine-Mediated Conditioned Place Preference in Mice

Frontiers in Behavioral Neuroscience, 2022
A high percentage of relapse to compulsive cocaine-taking and cocaine-seeking behaviors following abstinence constitutes a major obstacle to the clinical treatment of cocaine addiction.
Changliang Zhu, Changliang Zhu, Lei Wang, Jiangwei Ding, Hailiang Li, Hailiang Li, Din Wan, Yangyang Sun, Baorui Guo, Zhenquan He, Xiaofan Ren, Shucai Jiang, Shucai Jiang, Caibing Gao, Caibing Gao, Hua Guo, Tao Sun, Tao Sun, Feng Wang, Feng Wang   +19 more
doaj   +1 more source

"EFFECT OF APAMIN ON TOLERANCE TO COCAINE-INDUCED LOCOMOTOR ACTIVITY IN MICE" [PDF]

Acta Medica Iranica, 2004
In the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated.
H. R. Jamshidi, M. Rezayat M. R. Zarrindast   +1 more
doaj   +1 more source