Results 51 to 60 of about 188,136 (212)
Journal of Chemical Neuroanatomy, 2017 Cocaine is a naturally occurring and illicitly used psychostimulant drug. Cocaine acts at monoaminergic neurotransmitter transporters to block uptake of the monoamines, dopamine, serotonin and norepinephrine. The resulting increase of monoamines in the extracellular space underlies the positively reinforcing effects that cocaine users seek.
Oliver, Kudlacek +9 more
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Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine
Scientific Reports, 2016 Addiction to cocaine and other psychostimulants represents a major public health crisis. The development and persistence of addictive behaviors comes from a complex interaction of genes and environment - the precise mechanisms of which remain elusive. In
Drew D. Kiraly +8 more
semanticscholar +1 more source
Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes.
PLoS ONE, 2013 ObjectiveThe search for genetic vulnerability factors in cocaine dependence has focused on the role that neuroplasticity plays in addiction. However, like many other drugs, the ability of an individual to metabolize cocaine can also influence ...
André Brooking Negrão +6 more
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Addiction Neuroscience, 2023 The hypocretins/orexins (HCRT) have been demonstrated to influence motivation for cocaine through actions on dopamine (DA) transmission. Pharmacological or genetic disruption of the hypocretin receptor 1 (Hcrtr1) reduces cocaine self-administration ...
Emily M. Black +6 more
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A mechanism for the inhibition of neural progenitor cell proliferation by cocaine.
PLoS Medicine, 2008 BackgroundPrenatal exposure of the developing brain to cocaine causes morphological and behavioral abnormalities. Recent studies indicate that cocaine-induced proliferation inhibition and/or apoptosis in neural progenitor cells may play a pivotal role in
Chun-Ting Lee +13 more
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Genetic and epigenetic analysis of the serotonin 2A receptor in the context of cocaine abuse
Epigenetics, 2022 Despite more than 2 million American cocaine users monthly, there is no approved drug for treating cocaine use disorder. Cocaine use disorder has a multifactorial aetiology, including both genetic and environmental factors.
Aysheh Alrfooh, Ryan M. Smith
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Carrots and sticks fail to change behavior in cocaine addiction
Science, 2016 Punishment doesn't work in cocaine addicts Addiction is extremely difficult to treat, particularly cocaine use disorder. Animal experiments have led to the concept of drug addiction as abnormal goal-directed learning and habit formation.
K. Ersche +9 more
semanticscholar +1 more source
Melatonin decreases cocaine-induced locomotor activity in pinealectomized rats
Brazilian Journal of PsychiatryObjective: Several studies have shown that the time of day regulates the reinforcing effects of cocaine. Additionally, melatonin and its MT1 and MT2 receptors have been found to participate in modulation of the reinforcing effects of such addictive drugs
Susana Barbosa-Méndez +1 more
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Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion. [PDF]
PLoS ONE, 2012 Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of CocH
Marilyn E Carroll +9 more
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Postgraduate Medical Journal, 2005 Abstract Cocaine is the second commonest illicit drug used and the most frequent cause of drug related deaths. Its use is associated with both acute and chronic complications that may involve any system, the most common being the cardiovascular system.
M, Egred, G K, Davis
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