Results 71 to 80 of about 188,136 (212)

Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/− mice

Translational Psychiatry, 2021
Cocaine addiction causes serious health problems, and no effective treatment is available yet. We previously identified a genetic risk variant for cocaine addiction in the PLCB1 gene and found this gene upregulated in postmortem brains of cocaine abusers
Judit Cabana-Domínguez, Elena Martín-García, Ana Gallego-Roman, Rafael Maldonado, Noèlia Fernàndez-Castillo, Bru Cormand   +5 more
doaj   +1 more source

A latent class analysis of the past-30-day substance use patterns among lifetime cocaine users: Findings from a community sample in North Central Florida

Addictive Behaviors Reports, 2019
Objectives: Cocaine use is increasing and many cocaine users engage in polysubstance use. Within polysubstance use, relationships among use of individual substances are necessarily complex.
Yiyang Liu, Amy L. Elliott, Mirsada Serdarevic, Robert F. Leeman, Linda B. Cottler   +4 more
doaj   +1 more source

Cocaine hallucinations

American Journal of Psychiatry, 1978
The author reviews the literature on hallucinations that occur as a result of acute and chronic administration of cocaine. He examined the phenomenology of cocaine hallucinations in a group of 85 recreational cocaine users, 15 of whom reported hallucinatory experiences in visual, tactile, olfactory, auditory, and gustatory modalities.
openaire   +2 more sources

DAT isn’t all that: cocaine reward and reinforcement requires Toll Like Receptor 4 signaling

Molecular Psychiatry, 2015
The initial reinforcing properties of drugs of abuse, such as cocaine, are largely attributed to their ability to activate the mesolimbic dopamine system.
Alexis L. Northcutt, Mark R. Hutchinson, Xiaohui Wang, Michael V. Baratta, Takato Hiranita, Thomas A. Cochran, Matthew B. Pomrenze, E. Galer, T. Kopajtic, C. Li, Jose Amat, G. Larson, D. C. Cooper, Y. Huang, Casey E. O’Neill, Hang Yin, Hang Yin, N. Zahniser, Jon Katz, Kenner C. Rice, S. Maier, R. Bachtell, L. R. Watkins   +22 more
semanticscholar   +1 more source

4141 Molecular Signatures of Cocaine Toxicity in Postmortem Human Brain and Neurons

Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: The goal of this project is to identify new therapeutic targets and biomarkers to treat or prevent cocaine toxicity by investigating proteomic, transcriptomic and epigenetic signatures of cocaine exposure in human subjects.
Emily Frances Mendez, Laura Stertz, Gabriel Fries, Ruifeng Hu, Thomas Meyer, Zhongming Zhao, Consuelo Walss-Bass   +6 more
doaj   +1 more source

Trends in cocaine use and cocaine-related harms in Ireland: a retrospective, multi-source database study

BMC Public Health
Background Increased cocaine supply has coincided with increased global cocaine use. In 2019 Ireland had one of the highest last-year rates of cocaine use in Europe.
Deirdre Mongan, Seán R. Millar, Anne Marie Carew, Cathy Kelleher, Antoinette Daly, Suzi Lyons, Brian Galvin, Bobby P. Smyth   +7 more
doaj   +1 more source

Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats

Scientific Reports
Cocaine dependence is a serious world-wide public health problem without an FDA-approved pharmacotherapy. We recently designed and discovered a highly efficient long-acting cocaine hydrolase CocH5-Fc(M6).
Huimei Wei, Johnathan E. LeSaint, Zhenyu Jin, Chang-Guo Zhan, Fang Zheng   +4 more
doaj   +1 more source

Reduced frontal brain volume in non-treatment seeking cocaine dependent individuals: exploring the role of impulsivity, depression and smoking

Frontiers in Human Neuroscience, 2014
In cocaine-dependent patients, grey matter (GM) volume reductions have been observed in the frontal lobes that are associated with duration of cocaine use.
Cleo Lina Crunelle, Cleo Lina Crunelle, Anne Marije eKaag, Guido eVan Wingen, Hanna E. van den Munkhof, Judith eHomberg, Liesbeth eReneman, Wim eVan Den Brink, Wim eVan Den Brink   +8 more
doaj   +1 more source

Cocaine self-administration and extinction leads to reduced GFAP expression and morphometric features of astrocytes in the nucleus accumbens core

Biological Psychiatry, 2015
Background As a more detailed picture of nervous system function emerges, diversity of astrocyte function becomes more widely appreciated. While it has been shown that cocaine experience impairs astroglial glutamate uptake and release in the nucleus ...
Michael D. Scofield, Hao Li, Benjamin M. Siemsen, Kati L. Healey, Phuong K. Tran, Nicholas Woronoff, H. Boger, P. Kalivas, K. Reissner   +8 more
semanticscholar   +1 more source

Corticostriatal cocaine-seeking ensembles are defined by differing gene expression from sucrose-seeking ensembles using a within-subject dual self-administration and seeking mouse model

Addiction Neuroscience
Recurrent cocaine seeking is a hallmark of cocaine use disorder. To develop therapeutic targets, it is critical to understand the neurobiological changes specific to cocaine-seeking in context with the seeking of non-drug rewards, e.g., sucrose.
Carl G. Litif, Levi T. Flom, Kathryn L. Sandum, Skylar L. Hodgins, Lucio Vaccaro, Jerry A. Stitzel, Nathan Ungerleider, Maria Constanza Mannino, Jason P. Gigley, Todd A. Schoborg, Ana-Clara Bobadilla   +10 more
doaj   +1 more source