Cocaine Addiction as a Homeostatic Reinforcement Learning Disorder [PDF]
, 2017 Drug addiction implicates both reward learning and homeostatic regulation mechanisms of the brain. This has stimulated 2 partially successful theoretical perspectives on addiction.
Durand, A. +4 more
core +1 more source
Aptamer-based cocaine assay using a nanohybrid composed of ZnS/Ag2Se quantum dots, graphene oxide and gold nanoparticles as a fluorescent probe [PDF]
, 2020 Authors report on a new fluoro-graphene-plasmonic nanohybrid aptamer-based fluorescent nanoprobe for cocaine. To construct the nanoprobe, newly synthesized glutathione-capped ZnS/Ag 2Se quantum dots (QDs) were first conjugated to graphene oxide (GO) to ...
Abdolvand, Amin +4 more
core +2 more sources
The Effects of Excitatory and Inhibitory Social Cues on Cocaine-Seeking Behavior
Frontiers in Behavioral Neuroscience, 2016 Social partners influence the likelihood of using drugs, developing a substance use disorder, and relapse to drug use after a period of abstinence. Preclinical studies report that social cues influence the acquisition of cocaine use, the escalation of ...
Mark Andrew Smith +2 more
doaj +1 more source
Oral Administration of Levo-Tetrahydropalmatine Attenuates Reinstatement of Extinguished Cocaine Seeking by Cocaine, Stress or Drug-Associated Cues in Rats [PDF]
, 2011 Cocaine addiction is characterized by a persistently heightened susceptibility to drug relapse. For this reason, the identification of medications that prevent drug relapse is a critical goal of drug abuse research.
Baker, David A. +9 more
core +2 more sources
Understanding Substance Use and Suicide Risk Among LGBTQ+ College Students Post‐COVID‐19
Journal of Addictions &Offender Counseling, EarlyView.ABSTRACT This study examines the reported frequency of substance use, levels of suicide risk, and their relationships among LGBTQ+ college students (N = 192) following the COVID‐19 pandemic. Participants most commonly reported alcohol and marijuana use, and least commonly reported unprescribed prescription opioid or heroin use.
Afroze N. Shaikh +6 more
wiley +1 more source
Endogenous Dopamine and Endocannabinoid Signaling Mediate Cocaine-Induced Reversal of AMPAR Synaptic Potentiation in the Nucleus Accumbens Shell [PDF]
, 2018 Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior.
Hearing, Matthew +3 more
core +2 more sources
Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]
, 2010 Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa +11 more
core +2 more sources
Journal of Counseling &Development, EarlyView.ABSTRACT The relationship between trauma and addictive behaviors is well‐established, yet factors mediating this relationship remain understudied. Given the prevalence of addictive behaviors among collegiate populations, we used path analysis to explore the mediating role of arousal dysregulation in the relationship between childhood trauma and a ...
Amanda L. Giordano +3 more
wiley +1 more source
Ibrutinib as a potential therapeutic for cocaine use disorder
Translational Psychiatry, 2021 Cocaine use presents a worldwide public health problem with high socioeconomic cost. No current pharmacologic treatments are available for cocaine use disorder (CUD) or cocaine toxicity.
Spencer B. Huggett +7 more
doaj +1 more source
Augmented Cocaine Seeking in Response to Stress or CRF Delivered into the Ventral Tegmental Area Following Long-Access Self-Administration Is Mediated by CRF Receptor Type 1 But Not CRF Receptor Type 2 [PDF]
, 2011 Stressful events are determinants of relapse in recovering cocaine addicts. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing factor (CRF) regulation of neurocircuitry ...
Baker, David A. +6 more
core +2 more sources