Results 91 to 100 of about 309,381 (308)

Trends in cocaine use and cocaine-related harms in Ireland: a retrospective, multi-source database study

BMC Public Health
Background Increased cocaine supply has coincided with increased global cocaine use. In 2019 Ireland had one of the highest last-year rates of cocaine use in Europe.
Deirdre Mongan, Seán R. Millar, Anne Marie Carew, Cathy Kelleher, Antoinette Daly, Suzi Lyons, Brian Galvin, Bobby P. Smyth   +7 more
doaj   +1 more source

Enzymatic digestion and selective quantification of underivatised [delta]9-tetrahydrocannabinol and cocaine in human hair using gas chromatography-mass spectrometry. [PDF]

, 2012
Gas chromatography-mass spectrometric (GC-MS) methods for drug analysis routinely employ derivatising reagents. The aim of this paper was to develop a method for the analysis of two recreational drugs, delta-9-tetrahydrocannabinol ([delta](9)-THC) and ...
Barker, James, Breidi, Salah Eddine, Naughton, Declan, Petroczi, Andrea   +3 more
core   +3 more sources

Do Injury, Depression, and PTSD Mediate the Relationships Between Latent Profiles of Cumulative Lifetime Violence and Chronic Pain Disability in Men?

Research in Nursing &Health, EarlyView.
ABSTRACT Knowledge of association between violence and chronic pain in men is limited by neglect of violence experiences as perpetrator, disregard of heterogeneity in cumulative lifetime violence severity (CLVS), weak understanding of mediation pathways, and inattention to social determinants of health (SDOH).
Judith Wuest, Sue O'Donnell, Kelly Scott‐Storey, Charlene D. Vincent, Jeannie Malcolm   +4 more
wiley   +1 more source

The visible and invisible drivers of biocultural loss in the Amazon

People and Nature, EarlyView.
Abstract The Amazon is rapidly approaching an ecological tipping point driven by deforestation, forest degradation and global climate change. These are visible issues that receive increasing political and public attention. However, the accelerating biocultural loss in the Amazon, including the extinction of Indigenous languages, the disruption of ...
Torsten Krause, Mairon G. Bastos Lima, Jesica López, Karolin Obert, Juan A. Samper, Ana Maria Vargas   +5 more
wiley   +1 more source

Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats

Scientific Reports
Cocaine dependence is a serious world-wide public health problem without an FDA-approved pharmacotherapy. We recently designed and discovered a highly efficient long-acting cocaine hydrolase CocH5-Fc(M6).
Huimei Wei, Johnathan E. LeSaint, Zhenyu Jin, Chang-Guo Zhan, Fang Zheng   +4 more
doaj   +1 more source

Corticostriatal cocaine-seeking ensembles are defined by differing gene expression from sucrose-seeking ensembles using a within-subject dual self-administration and seeking mouse model

Addiction Neuroscience
Recurrent cocaine seeking is a hallmark of cocaine use disorder. To develop therapeutic targets, it is critical to understand the neurobiological changes specific to cocaine-seeking in context with the seeking of non-drug rewards, e.g., sucrose.
Carl G. Litif, Levi T. Flom, Kathryn L. Sandum, Skylar L. Hodgins, Lucio Vaccaro, Jerry A. Stitzel, Nathan Ungerleider, Maria Constanza Mannino, Jason P. Gigley, Todd A. Schoborg, Ana-Clara Bobadilla   +10 more
doaj   +1 more source

Rabies screen reveals GPe control of cocaine-triggered plasticity. [PDF]

, 2017
Identification of neural circuit changes that contribute to behavioural plasticity has routinely been conducted on candidate circuits that were preselected on the basis of previous results.
AE Stepien, AH Gittis, B Weissbourd, BN Armbruster, Boris D. Heifets, C Hammond, C Lüscher, Christina K. Kim, CM Bäckman, D Lin, EJ Nestler, ES Boyden, F-M Zhou, G Schiavo, H Taniguchi, HH Yin, IR Wickersham, JA Shuen, JS Park, K Miyamichi, K Miyamichi, K Yonehara, Karl Deisseroth, Katherine E. DeLoach, Kevin T. Beier, KF Raab-Graham, KT Beier, L Madisen, L Petreanu, L Ye, LA Gunaydin, LA Schwarz, Lin Wai Hung, Liqun Luo, M Watabe-Uchida, M Xue, MJ Krashes, NR Wall, P Rajasethupathy, Paul Hoerbelt, PE Rothwell, PW Kalivas, RC Pierce, RL Albin, Robert C. Malenka, S Hippenmeyer, S Lammel, S Lammel, SHR Oliet, Sophie Neuner, Timothy J. Mosca, TJ Mosca, TJ Stachniak, TN Lerner, Y Smith   +54 more
core   +2 more sources

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Reduced frontal brain volume in non-treatment seeking cocaine dependent individuals: exploring the role of impulsivity, depression and smoking

Frontiers in Human Neuroscience, 2014
In cocaine-dependent patients, grey matter (GM) volume reductions have been observed in the frontal lobes that are associated with duration of cocaine use.
Cleo Lina Crunelle, Cleo Lina Crunelle, Anne Marije eKaag, Guido eVan Wingen, Hanna E. van den Munkhof, Judith eHomberg, Liesbeth eReneman, Wim eVan Den Brink, Wim eVan Den Brink   +8 more
doaj   +1 more source

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]

, 2008
Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer, Baker, David A., Grier, Mark D., Kau, Kristen S., Madayag, Aric, Mantsch, John R.   +5 more
core   +1 more source