Results 171 to 180 of about 307,196 (303)

Synaptogyrin-3 plays a critical role in addiction-related dopamine dysfunction and behavioral maladaptations. [PDF]

Proc Natl Acad Sci U S A
Peck EG, Emerson SD, Curry AM, Holter KM, Estave PM, Sens JP, Colarusso OA, Farris SP, Kiraly DD, Gould RW, McCool BA, Calipari ES, Holleran KM, Jones SR.   +13 more
europepmc   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice. [PDF]

Front Pharmacol
de Oliveira GL, Machado da Silva MC, Gomes GF, Ribeiro RDS, Cussat GR, Fernandes RA, Souza JLN, Fernandes HB, de Miranda AS, Santos VR, Bueno LL, Vieira LB, Moreira FA, de Oliveira ACP.   +13 more
europepmc   +1 more source

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini, Riccardo Camilotto, Michele Maritan, Erika Morrone, Stephen Afriyie Boateng, Anna Vacilotto, Salvatore Pacifico, Remo Guerrini, Nurulain T. Zaveri, Girolamo Calo'   +9 more
wiley   +1 more source

Transcranial magnetic stimulation in cocaine use disorder and the risk of seizure: a review of the evidence. [PDF]

Front Psychiatry
Imperio CG, Parmon E, Steele VR, Blevins D, Chalme R, Wai JM, Brady K, Heilig M, Hanlon CA, Levin FR, Martinez D.   +10 more
europepmc   +1 more source

Cocaine Substitutes [PDF]

New England Journal of Medicine, 1980
openaire   +2 more sources

Maternal anorexia nervosa and risk of mental and neurodevelopmental morbidity in offspring

Child and Adolescent Mental Health, EarlyView.
Background Anorexia nervosa has the potential to affect fetal neurodevelopment. We examined the association between maternal anorexia nervosa and mental, substance‐related, and neurodevelopmental morbidity in offspring. Methods We conducted a retrospective cohort study of 1,269,370 children in Quebec, Canada, between 2006 and 2022.
Sam Amar, Gabriel Côté‐Corriveau, Mimi Israël, Howard Steiger, Nancy Low, Nicholas Chadi, Émilie Brousseau, Nahantara Lafleur, Nathalie Auger   +8 more
wiley   +1 more source

Sex and dose-dependent effects of cannabidiol on cocaine consumption in mice. [PDF]

Transl Psychiatry
Llerena V, Tic I, Llach-Folcrà M, Valverde O, Medrano M.   +4 more
europepmc   +1 more source

Making Accurate Judgements in Child Welfare: Comparing ChatGPT With Qualified Social Workers

Child &Family Social Work, EarlyView.
ABSTRACT This study compares the judgemental accuracy of child and family social workers (n = 581) with ChatGPT, a generative AI model. Using 12 anonymized referrals, participants were asked predictive questions to evaluate accuracy through Brier scores. ChatGPT outperformed the average social worker on 11 of the 12 referrals, though the difference was
David Wilkins, Verity Benett
wiley   +1 more source

Assessing craving in cocaine and cocaine base paste users: validation of the Cocaine Craving Questionnaire-Brief in a Chilean sample. [PDF]

Addict Sci Clin Pract
Bustamante F, Labbé S, Arriaza T, Huerta I, Vega MC, Alvarado ME, Vergés A.   +6 more
europepmc   +1 more source