Results 141 to 150 of about 15,480,873 (292)

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Unemployment but not cocaine use influences social jetlag in patients with cocaine use disorder

Neuroscience Applied, 2023
J. Fernando, K.D. Ersche
openaire   +1 more source

The dual incretin agonist tirzepatide blunts nicotine‐induced behaviours and neurochemistry in male mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Nicotine dependence remains one of the leading causes of morbidity and mortality worldwide, with high relapse rates and post‐cessation weight gain representing persistent barriers to sustained abstinence. The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) have ...
Christian E. Edvardsson, Thaynnam A. Emous, Sarah Witley, Mia Ericson, Louise Adermark, Elisabet Jerlhag   +5 more
wiley   +1 more source

Reply to: “Letter to the Editor: Cocaine use and cocaine use disorder - Revisiting epidemiology and clinical impact”

Journal of Psychiatric Research, 2021
Vigna-Taglianti, F D, Berchialla, P, Nibbio, G, Mangiapane, C, Colombi, N, Oliva, F   +5 more
openaire   +3 more sources

Perinatal, socioenvironmental, and neurological factors to predict motor delay in infants born preterm

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To determine the best combination of perinatal characteristics, socioenvironmental factors, and neurological examination at term‐equivalent age for identifying motor delay at 3 months 2 weeks corrected age in infants born preterm between 29 weeks and 36 weeks of gestation.
Melanie Gagnon, Mathieu Dehaes, Mi‐Suk Kang Dufour, Marie‐Michèle Gagnon, Gabriel Côté‐Corriveau, Leanne Brabant, Sophie Tremblay, Thuy Mai Luu, Marie‐Noelle Simard   +8 more
wiley   +1 more source

Wellbeing of trans and gender‐diverse people with HIV in the United Kingdom: Results from Positive Voices 2022

HIV Medicine, EarlyView.
Abstract Objectives This national cross‐sectional observational study aimed to assess mental health, quality of life, supportive network, experiences of HIV‐related stigma in healthcare and unmet service need among trans and gender‐diverse people with HIV, compared to cisgender people with HIV.
H. Kitt, C. Kelly, A. Aghaizu, M. Ross, F. C. Lampe, C. J. Smith, V. Martin, C. Humphreys, A. Brown, A. Sparrowhawk, M. Kall, J. Sewell, E. Wainwright, V. Delpech, G. Davis, A. Farah, A. Fasanya, A. J. Rodger, T. Đuretić, PV2022 Study Group   +19 more
wiley   +1 more source

Prefrontal-centered cortical alterations and network dysconnectivity in cocaine use disorder. [PDF]

Front Psychiatry
Rothmann LM, Portolan ET, Bianchini Esper N, Sanvicente-Vieira B, Bittencourt AML, Viola TW, Ferreira PE, Eskildsen SF, Franco AR, Grassi-Oliveira R.   +9 more
europepmc   +1 more source