Results 1 to 10 of about 105,708 (356)

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

Frontiers in Aging Neuroscience, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +2 more sources

Cisplatin is retained in the cochlea indefinitely following chemotherapy

Nature Communications, 2017
Cisplatin chemotherapy causes permanent hearing loss in 40–80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry
Andrew M Breglio, Aaron E Rusheen, Katharine A Fernandez   +2 more
exaly   +2 more sources

The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells

Scientific Reports, 2020
Cells of the immune system are present in the adult cochlea and respond to damage caused by noise exposure. However, the types of immune cells involved and their locations within the cochlea are unclear.
Vikrant Rai, Megan B Wood
exaly   +2 more sources

Clinical Validation of Manual Measurement of Cochlea Length With Post‐Operative Electrode Insertion Depth: A Pilot Study [PDF]

Laryngoscope Investigative Otolaryngology
Objective To clinically validate manual measurement of cochlear length from pre‐operative image of cochlea with post‐operative image of cochlear implant (CI) electrode.
Fei Wang, Dharmikkumar Anaghan, Anandhan Dhanasingh, Lian Hui   +3 more
doaj   +2 more sources

Age-Related Changes in Immune Cells of the Human Cochlea

Frontiers in Neurology, 2019
Age-related hearing loss is a chronic degenerative disorder affecting one in two individuals above the age of 75. Current population projections predict a steady climb in the number of older individuals making the search for interventions to prevent or ...
Hainan Lang
exaly   +2 more sources

Expression of ApoE and Spp1 in the cochlea and auditory cortex of age-related hearing loss mice [PDF]

Brazilian Journal of Otorhinolaryngology
Objective: Screen for differential proteins in the cochlea of mice associated with Age-Related Hearing Loss (ARHL), analyze and validate the expression of specific differential proteins and genes in the cochlea and auditory cortex of ARHL mice, and ...
Yingxue Yuan, Junhong Zhang, Jingyi Zhao, Xiru Zhang, Zhixin Cao   +4 more
doaj   +2 more sources

Deafness gene expression patterns in the mouse cochlea found by microarray analysis.

PLoS ONE, 2014
BackgroundTonotopy is one of the most fundamental principles of auditory function. While gradients in various morphological and physiological characteristics of the cochlea have been reported, little information is available on gradient patterns of gene ...
Hidekane Yoshimura, Yutaka Takumi, Shin-ya Nishio, Nobuyoshi Suzuki, Yoh-ichiro Iwasa, Shin-ichi Usami   +5 more
doaj   +2 more sources

Where hearing starts: the development of the mammalian cochlea

Journal of Anatomy, 2016
Martin L Basch, Hsin-I Jen, Andrew K Groves   +2 more
exaly   +2 more sources

Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance An increasing number of therapeutic strategies are being designed and tested in animal models for numerous forms of hereditary deafness, the most frequent genetic sensorineural disorder.
Philippe Jean, Fabienne Wong Jun Tai, A. Singh-Estivalet, A. Lelli, Cyril Scandola, Sébastien Megharba, Sandrine Schmutz, Solène Roux, S. Mechaussier, Muriel Sudres, Enguerran Mouly, Anne-Valérie Heritier, C. Bonnet, A. Mallet, S. Novault, V. Libri, C. Petit, Nicolas Michalski   +17 more
semanticscholar   +1 more source

Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging

Scientific Reports, 2021
The human cochlea transforms sound waves into electrical signals in the acoustic nerve fibers with high acuity. This transformation occurs via vibrating anisotropic membranes (basilar and tectorial membranes) and frequency-specific hair cell receptors ...
Hao Li, Luke Helpard, Jonas Ekeroot, S. A. Rohani, N. Zhu, H. Rask-Andersen, H. Ladak, S. Agrawal   +7 more
semanticscholar   +1 more source