Vibration hotspots reveal longitudinal funneling of sound-evoked motion in the mammalian cochlea [PDF]
Nature Communications, 2018 The micromechanical mechanisms that underpin tuning and dynamic range compression in the mammalian inner ear are fundamental to hearing, but poorly understood.
Nigel P Cooper +2 more
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Development of the cochlea [PDF]
Development (Cambridge), 2020 ABSTRACT The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the primary structure for the perception of sound. Along the length of the cochlear spiral is the organ of Corti, a highly derived and rigorously patterned sensory epithelium that acts to convert auditory stimuli into neural impulses.
Elizabeth Driver, Matthew W Kelley
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Mechanisms of sensorineural cell damage, death and survival in the cochlea [PDF]
Frontiers in Aging Neuroscience, 2015 The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ann C Y Wong, Allen F Ryan
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Mechanics of the Mammalian Cochlea [PDF]
Physiological Reviews, 2001 In mammals, environmental sounds stimulate the auditory receptor, the cochlea, via vibrations of the stapes, the innermost of the middle ear ossicles. These vibrations produce displacement waves that travel on the elongated and spirally wound basilar membrane (BM). As they travel, waves grow in amplitude, reaching a maximum and then dying out.
Mario A Ruggero
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Cisplatin is retained in the cochlea indefinitely following chemotherapy
Nature Communications, 2017 Cisplatin chemotherapy causes permanent hearing loss in 40–80% of treated patients. It is unclear whether the cochlea has unique sensitivity to cisplatin or is exposed to higher levels of the drug. Here we use inductively coupled plasma mass spectrometry
Andrew M Breglio +2 more
exaly +2 more sources
Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea [PDF]
Journal of Neuroscience, 2017 Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and humans. The release of ATP from connexin hemichannels in cochlear nonsensory cells
Stuart L. Johnson +8 more
openalex +2 more sources
Neuromorphic acoustic sensing using an adaptive microelectromechanical cochlea with integrated feedback [PDF]
Nature Electronics, 2023 Claudia Hamann +2 more
exaly +2 more sources
Clinical Validation of Manual Measurement of Cochlea Length With Post‐Operative Electrode Insertion Depth: A Pilot Study [PDF]
Laryngoscope Investigative OtolaryngologyObjective To clinically validate manual measurement of cochlear length from pre‐operative image of cochlea with post‐operative image of cochlear implant (CI) electrode.
Fei Wang +3 more
doaj +2 more sources
Isolating the human cochlea to generate bone powder for ancient DNA analysis [PDF]
Nature Protocols, 2019 Ron Pinhasi +3 more
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Deafness gene expression patterns in the mouse cochlea found by microarray analysis.
PLoS ONE, 2014 BackgroundTonotopy is one of the most fundamental principles of auditory function. While gradients in various morphological and physiological characteristics of the cochlea have been reported, little information is available on gradient patterns of gene ...
Hidekane Yoshimura +5 more
doaj +2 more sources