Results 91 to 100 of about 66,419 (330)

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Artificial hearing systems based on functional cochlea models

International Journal of Extreme Manufacturing
The cochlea is one of the most complex organs in the human body, exhibiting a complex interplay of characteristics in acoustic, mechanical, electrical, and biological functions.
Jinke Chang, Sita Tarini Clark, Iwan Roberts, Filip Hrncirik, Zhipeng Zhang, Manohar Bance   +5 more
doaj   +1 more source

Fast Waves at the Base of the Cochlea.

PLoS ONE, 2015
Georg von Békésy observed that the onset times of responses to brief-duration stimuli vary as a function of distance from the stapes, with basal regions starting to move earlier than apical ones.
Alberto Recio-Spinoso, William S Rhode
doaj   +1 more source

Oncomodulin: The Enigmatic Parvalbumin Protein

Frontiers in Molecular Neuroscience, 2019
EF-hand Ca2+-binding protein family members, α- and β-parvalbumins have been studied for decades. Yet, considerable information is lacking distinguishing functional differences between mammalian α-parvalbumin (PVALB) and oncomodulin (OCM), a branded β ...
Leslie K. Climer, Leslie K. Climer, Andrew M. Cox, Andrew M. Cox, Timothy J. Reynolds, Dwayne D. Simmons, Dwayne D. Simmons, Dwayne D. Simmons   +7 more
doaj   +1 more source

NEUROBIOLOGY OF THE COCHLEA

Le Journal de Physique Colloques, 1990
The two major advances in the knowledge of cochlear physiology during the last decade have been : 1) - the discovery of the contractile properties of outer hair cells (OHCs), one of the two types of mechanoreceptors ; and 2) - the identification of most of the neuroactive substances in the cochlea.
openaire   +2 more sources

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Curcumin pretreatment and post-treatment both improve the antioxidative ability of neurons with oxygen-glucose deprivation

Neural Regeneration Research, 2015
Recent studies have shown that induced expression of endogenous antioxidative enzymes thr-ough activation of the antioxidant response element/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway may be a neuroprotective strategy. In this study, rat
Jing-xian Wu, Lu-yu Zhang, Yan-lin Chen, Shan-shan Yu, Yong Zhao, Jing Zhao   +5 more
doaj   +1 more source

Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development

Scientific Reports, 2015
Organ development requires well-established intercellular communication to coordinate cell proliferations and differentiations. MicroRNAs (miRNAs) are small, non-coding RNAs that can broadly regulate gene expression and play a critical role in the organ ...
Yan Zhu, L. Zong, Ling Mei, Hong-Bo Zhao
semanticscholar   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Upregulated Expression and Shifted Distribution of Melatonin and Its Synthesizing Enzymes From Postnatal to Young Adult Rat Cochleae. [PDF]

Dev Neurobiol
ABSTRACT The cochlea's cellular architecture plays a critical role in auditory perception, yet is highly susceptible to degenerative factors. While melatonin is known for its antioxidative properties in the adult cochlea, its expression during early development remains understudied.
Orsolic M, Diensthuber M, Stöver T, Geißler C.   +3 more
europepmc   +2 more sources