Results 101 to 110 of about 66,419 (330)
Scientific Reports, 2015 Pannexin1 (Panx1) is a gap junction gene in vertebrates whose proteins mainly function as non-junctional channels on the cell surface. Panx1 channels can release ATP under physiological conditions and play critical roles in many physiological and ...
Jin Chen +4 more
semanticscholar +1 more source
LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
Advanced Science, EarlyView.This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang +15 more
wiley +1 more source
PLoS Genetics, 2019 The mouse organ of Corti, housed inside the cochlea, contains hair cells and supporting cells that transduce sound into electrical signals. These cells develop in two main steps: progenitor specification followed by differentiation.
Lu M Yang +3 more
doaj +1 more source
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
Variations in microanatomy of the human cochlea
The Journal of comparative neurology, 2014 The human cochlea shows considerable interindividual variability in size and morphology. In order to develop atraumatic cochlear implant (CI) electrodes, high‐precision details of the variability of human anatomy are required.
E. Avci +4 more
semanticscholar +1 more source
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Interference Pattern Caused by Bilateral Bone Conduction Stimulation Impairs Sound Localization
Advanced Science, EarlyView.This work explores how crosstalk‐induced wave interference affects bone conduction (BC) sound localization. Using a theoretical model, cadaveric vibrometry, and psychoacoustic tests, atypical BC lateralization patterns are revealed that contradict air conduction (AC) principles.
Liu‐Jie Ren +7 more
wiley +1 more source
Robust Cochlear-Model-Based Speech Recognition
Computers, 2019 Accurate speech recognition can provide a natural interface for human–computer interaction. Recognition rates of the modern speech recognition systems are highly dependent on background noise levels and a choice of acoustic feature extraction ...
Mladen Russo +3 more
doaj +1 more source
β-Catenin Is Required for Hair-Cell Differentiation in the Cochlea
Journal of Neuroscience, 2014 The development of hair cells in the auditory system can be separated into steps; first, the establishment of progenitors for the sensory epithelium, and second, the differentiation of hair cells.
Fuxin Shi +5 more
semanticscholar +1 more source