Results 121 to 130 of about 73,190 (256)
Cancer Science, EarlyView.SLC1A3 promotes colorectal cancer progression by transporting extracellular aspartate into tumor cells, thereby activating the PKC/MDM2/p53 pathway to enhance proliferation. Reduced extracellular aspartate, combined with p53‐dependent suppression of CSF2 and IL17C, drives M2 macrophage polarization via immune modulation, macrophage recruitment, and M2 ...
Chao Deng +9 more
wiley +1 more source
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, EarlyView.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source
Intermediate filaments link glutamate–aspartate transporter deficiency to cochlear synaptopathy
The FEBS Journal, EarlyView.In a healthy ear, GLAST transporters in supporting cells clear excess glutamate to protect auditory connections. When GLAST is missing, glutamate accumulates and leads to the destruction of structural scaffolding within the postsynaptic nerve endings. This internal collapse causes a loss of synapses that are essential for hearing, ultimately resulting ...
Paul Emmerich Krumpoeck +1 more
wiley +1 more source
Journal of Anatomy, EarlyView.In this study we show for the first time that the human basilar membrane contains elastin produced by the so‐called tympanic covering layer. It is believed to play an important functional role in human cochlear tuning, particularly low frequencies linked to our remarkable speech and music perception.
Wei Liu +9 more
wiley +1 more source
Deep Spiking Neural Network model for time-variant signals classification: a real-time speech recognition approach [PDF]
, 2018 Speech recognition has become an important task to improve the human-machine interface. Taking into account the limitations of current automatic speech recognition systems, like non-real time cloud-based solutions or power demand, recent interest for
Davidson, Simón +6 more
core
Sound offset responses become highly informative in the auditory cortex
The Journal of Physiology, EarlyView.Abstract figure legend Using large datasets of neural responses to diverse sounds recorded across four stages of the mouse auditory system (depicted and colour‐coded on the left), offset responses occurring after the termination of each sound (time window indicated by the orange shaded area superimposed with activity traces) were characterized and it ...
Charly Lamothe +3 more
wiley +1 more source
The what, which, when, why and who of Off responses in the auditory system
The Journal of Physiology, EarlyView.Abstract figure legend In this article, we will first review ‘What’ different mechanisms are involved in the generation of Off responses at the sub‐cortical and cortical level of the auditory system. Then, we evaluate ‘Which’ stimulus properties elicit Off responses at the different levels of the auditory system.
Jean‐Marc Edeline, Robert C. Liu
wiley +1 more source
Noise‐induced reduction and early recovery of superior paraolivary nucleus sound‐offset responses
The Journal of Physiology, EarlyView.Abstract figure legend Acoustic over‐exposure transiently disrupts auditory temporal processing in mouse superior paraolivary nucleus neurons. In control conditions, neurons exhibit robust sound‐offset (OFF) responses, which are abolished immediately following noise trauma, indicating impaired temporal encoding.
Mihai Stancu +4 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Graphical summary of our study. Rats with varying hearing experiences were bilaterally implanted with cochlear implants (CIs), and neural responses were recorded from the inferior colliculus (IC), an auditory midbrain region (left).
S. Fang +6 more
wiley +1 more source
Bilateral Carotid Artery Occlusion and Cochlear Oxidative Stress and Hearing Loss in Rats
Basic and Clinical Neuroscience, 2020 Introduction: This study aimed to evaluate the effects of bilateral carotid artery occlusion on cochlear oxidative stress and hearing status in rats. Methods: The rats were divided into two sets. The first set was used for electrophysiological recording (
Hamed Fanaei +2 more
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