Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley +1 more source
Introducing a translationally relevant mouse model of radiosurgery-induced unilateral hearing loss. [PDF]
Daskalou D +8 more
europepmc +1 more source
Labyrinthine Abnormalities on MRI in Untreated Otosclerosis: Prevalence and Clinical Relevance
In untreated otosclerosis with labyrinthine symptoms, delayed 3D FLAIR MRI rarely demonstrates endolymphatic hydrops but frequently reveals blood–labyrinth barrier (BLB) disruption. BLB enhancement is spatially associated with cochlear endosteal and round window involvement and increases with the severity of the hearing loss phenotype.
Héléna Pencroffi +7 more
wiley +1 more source
Progressive Sensorineural Hearing Loss Following Cisplatin Chemotherapy: Mechanisms Underlying Cochlear Retention and Long-Term Ototoxicity. [PDF]
Ruggiero A +6 more
europepmc +1 more source
3D‐Printed Electroanatomic Twins of Cadaveric Cochleae: A Platform for Cochlear Implant Testing
ABSTRACT Objectives Cochlear implants (CIs) can restore hearing to individuals with severe deafness, yet clinical outcomes vary widely because it remains difficult to predict how electrical currents interact with the unique anatomy of each cochlea. A central challenge in auditory rehabilitation is the lack of experimental systems that capture both the ...
Chloe Swords +7 more
wiley +1 more source
A Cross-Species Single-Cell Atlas Reveals Conserved Regulatory Networks and Candidate Hearing Loss Genes in the Cochlea. [PDF]
Cheng H, Ai F, Hua W, Bu F.
europepmc +1 more source
Regional Impedance Patterns in Cochlear Implantation: Influence of Demographic and Early Activation
Implantation age is a key determinant of electrode impedance behavior, with a region‐specific effect most pronounced in the apical cochlea. Younger recipients exhibit higher intraoperative impedance followed by a time‐dependent reversal at 6 months.
Eman Hajr +4 more
wiley +1 more source
Cochlear isolation in neonatal mice for <i>in vitro</i> and <i>ex vivo</i> models: an anatomical landmark-based protocol. [PDF]
Polikarpov EV +10 more
europepmc +1 more source
Abstract Objective To investigate the association between distortion product otoacoustic emission (DPOAE) signal‐to‐noise ratios (SNRs) and pure‐tone audiometry (PTA) thresholds in adolescents, both cross‐sectionally at age 18 and longitudinally by evaluating whether DPOAE SNRs at age 13 predict high‐frequency hearing loss (HFHL) at age 18.
Stefanie N. H. Reijers +5 more
wiley +1 more source
Evolutionary constraints impose multiple checkpoints that block mammalian sensory hair cell regeneration. [PDF]
Zhang X, Su Z, Guan D, Liu X, Xie H.
europepmc +1 more source

