Results 131 to 140 of about 67,013 (327)

Type 2 Diabetes Mellitus and Hearing Loss: A Prisma Systematic Review and Meta‐Analysis

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To conduct a systematic review and meta‐analysis to assess the association between type 2 diabetes and hearing loss. Data Sources Search conducted in PubMed and Scopus databases for articles published between January 2019 and April 2024.
Miguel Caballero‐Borrego   +1 more
wiley   +1 more source

Transtympanic Injection of Antioxidant‐Eluting Microparticles for Otoprotection From Cisplatin Toxicity in a Mouse Model

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Cisplatin is a chemotherapeutic agent with the undesirable side effect of ototoxicity. Transtympanic injections of antioxidant formulations may provide local otoprotection. We tested a novel antioxidant‐eluting microparticle for its otoprotective capability from systemic cisplatin as measured by cochlear electrophysiology.
Eric Michael Smith   +3 more
wiley   +1 more source

Severe Hearing Loss in Children With Central Nervous System Tumors: A Population‐Based Cancer in Young People in Canada (CYP‐C) Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Children with central nervous system (CNS) tumors are prone to treatment‐related hearing loss (HL) and subsequent functional impairment. This study reports a dedicated population‐based analysis of CNS tumor‐specific rates and predictors of early severe HL.
Hallie Coltin   +13 more
wiley   +1 more source

Clinical Advances and Challenges in Dose Constraints for Organs at Risk in Proton Therapy: A Systematic Review of the Last Decade's Literature

open access: yesPrecision Radiation Oncology, EarlyView.
This systematic review synthesizes decade‐long evidence from peer‐reviewed literature and clinical guidelines, critically evaluating current understanding of OARs tolerance in proton therapy. Abstract Proton beam therapy has demonstrated significant clinical efficacy across multiple malignancies, primarily attributed to its distinct physical dose ...
Jinghao Duan   +10 more
wiley   +1 more source

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

open access: yesSensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He   +7 more
wiley   +1 more source

Conductive Materials and Electrical Stimulation for Auditory Restoration

open access: yesSensory Neuroscience, EarlyView.
Applications of electroconductive biomaterials and electrical stimulation in cochlear tissue engineering.(1) Enable auditory neural repair through conductive materials and electrical stimulation, enhancing neuron survival and synaptic plasticity.(2) Integrate optogenetic‐electrical systems and cochlear organoid platforms for frequency‐specific ...
Menghui Liao   +8 more
wiley   +1 more source

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