Results 131 to 140 of about 107,745 (350)

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic   +4 more
wiley   +1 more source

Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner.

open access: yesPLoS Genetics, 2019
The mouse organ of Corti, housed inside the cochlea, contains hair cells and supporting cells that transduce sound into electrical signals. These cells develop in two main steps: progenitor specification followed by differentiation.
Lu M Yang   +3 more
doaj   +1 more source

The cochlea [PDF]

open access: yesCurrent Biology, 2000
Ashmore, Jonathan, Gale, Jonathan
openaire   +2 more sources

Perceptual and electrophysiological masking of the auditory brainstem response : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]

open access: yes, 1987
Effective masking levels of the auditory brainstem response (ABR) to tonepips were established on 10 normal-hearing subjects at 500, 1000, 2000 and 4000 Hz, using white noise.
Houghton, Janene M
core  

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier. [PDF]

open access: yes, 2015
The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the 'cochlear amplifier' in each ear.
Cederholm, Jennie ME   +7 more
core   +2 more sources

Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development

open access: yesScientific Reports, 2015
Organ development requires well-established intercellular communication to coordinate cell proliferations and differentiations. MicroRNAs (miRNAs) are small, non-coding RNAs that can broadly regulate gene expression and play a critical role in the organ ...
Yan Zhu, L. Zong, Ling Mei, Hong-Bo Zhao
semanticscholar   +1 more source

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

open access: yesDevelopmental Dynamics, EarlyView.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee   +6 more
wiley   +1 more source

Evolutionary origins of ultrasonic hearing and laryngeal echolocation in bats inferred from morphological analyses of the inner ear [PDF]

open access: yes, 2013
PMCID: PMC3598973This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Davies, KTJ, Maryanto, I, Rossiter, SJ
core   +1 more source

Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality‐of‐Life Outcome

open access: yesHead &Neck, EarlyView.
ABSTRACT Objective To evaluate clinical outcomes and quality of life (QOL) following hypofractionated spot‐scanning proton therapy (SSPT) for head and neck malignant mucosal melanoma (HNMM). Methods This retrospective study included 39 patients treated with SSPT (60–64 Gy[RBE] in 15–16 fractions) between 2013 and 2023.
Koichiro Nakajima   +11 more
wiley   +1 more source

Six Hundred and Sixty Nanometer Light Exposure‐Induced Alterations in Actin Filament, Mitochondrial Morphological Dynamics, and Migration in Mesenchymal Stem Cells

open access: yesJournal of Biophotonics, EarlyView.
Six hundred and sixty nanometer light‐induced alteration of actin filament cytoskeleton, mitochondrial morphological dynamics, and enhanced migration in adipose‐derived mesenchymal stem cells. ABSTRACT Actin cytoskeleton alteration and cell homing/migration are crucial determinants for the success of stem cell (SC) based therapy.
Mahima Rastogi   +2 more
wiley   +1 more source

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