Results 151 to 160 of about 67,013 (327)

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

Single‐Nucleus Transcriptomics Uncovers Xaf1‐Driven PANoptosis as a Therapeutic Target in Aminoglycoside‐Induced Hearing Loss

Cell Proliferation, EarlyView.
Neomycin induces increased expression of Xaf1 in cochlear HCs, triggering PANoptosis, which encompasses pyroptosis, apoptosis and necroptosis (left). Targeted Xaf1 knockdown in HCs through gene therapy can significantly inhibit the occurrence of PANoptosis in HCs (right).
Xinlin Wang, Hairong Xiao, Jiheng Wu, Yanqin Lin, Yiheng Ao, Zixuan Ye, Xin Tan, Fanliang Kong, Xin Chen, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, EarlyView.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Isolating the human cochlea to generate bone powder for ancient DNA analysis

Nature Protocols, 2019
R. Pinhasi, D. Fernandes, K. Sirak, O. Cheronet   +3 more
semanticscholar   +1 more source

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

The FEBS Journal, EarlyView.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis, Nadine Gehle, Katia Cosentino   +2 more
wiley   +1 more source

Semicircular canal morphology in Rodentia and its relationship to locomotion

Journal of Anatomy, EarlyView.
Here, we present a selection of rodent inner ear 3D models in the lateral view, with rodents from seven locomotor categories (left to right: fossorial, semifossorial, semiaquatic, terrestrial, ricochetal, arboreal, and gliding). Semicircular canal (SCC) morphology, including radius of curvature and shape, can be differentiated between specialized forms
Lily Hou, Ornella C. Bertrand, Hiruni N. Mudannayake, Campbell Rolian, Susanne Cote   +4 more
wiley   +1 more source

Über die Altersveränderungen der Nervenfasern der Cochlea

, 1942
Moriyoshi Ide
openalex   +2 more sources

Determination of Traveling-Wave Velocity in the Human Cochlea [PDF]

, 1964
Stanley Zerlin, G. Donald Causey
openalex   +1 more source

The cochlear apex demystified: Implications from synchrotron radiation phase‐contrast imaging and microscopy for cochlear implantation

Journal of Anatomy, EarlyView.
This study is the first to present the detailed cellular organization and three‐dimensional (3D) tonotopic arrangement of the human organ of Corti, spiral ganglion, and central modiolus using synchrotron radiation phase‐contrast imaging (SR‐PCI) with matched histological cross‐sections.
Hao Li, Rudolf Glueckert, Anneliese Schrott‐Fischer, Karin Staxäng, Hanif M. Ladak, Helge Rask‐Andersen, Sumit Agrawal   +6 more
wiley   +1 more source

The hearing capabilities of the Dromornithidae (Aves), with inferences on acoustic communication and ecology

Journal of Anatomy, EarlyView.
The preservation of bony structures which enclose the hearing organs (ECD) provide a basis for interpreting the hearing capabilities of the extinct, flightless Dromornithidae (Aves). Although the length of the dromornithid ECD was especially short, relative to basicranial length, it conformed to the negative allometric scaling relationships observed in
Phoebe L. McInerney, Warren D. Handley, Trevor H. Worthy   +2 more
wiley   +1 more source