Results 11 to 20 of about 66,419 (330)

Identification and Characterization of TMEM119-Positive Cells in the Postnatal and Adult Murine Cochlea

Brain Sciences, 2023
Transmembrane protein 119 (TMEM119) is expressed in a subset of resident macrophage cells of the brain and was proposed as a marker for native brain microglia. The presence of cells expressing TMEM119 in the cochlea has not yet been described.
Mohamed Bassiouni, Alina Smorodchenko, Heidi Olze, Agnieszka J. Szczepek   +3 more
doaj   +1 more source

Monitoring blood-flow in the mouse cochlea using an endoscopic laser speckle contrast imaging system. [PDF]

PLoS ONE, 2018
Laser speckle contrast imaging (LSCI) enables continuous high-resolution assessment of microcirculation in real-time. We applied an endoscope to LSCI to measure cochlear blood-flow in an ischemia-reperfusion mouse model.
Tae Hoon Kong, Sunkon Yu, Byungjo Jung, Jin Sil Choi, Young Joon Seo   +4 more
doaj   +1 more source

Variations in cochlea shape reveal different evolutionary adaptations in primates and rodents

Scientific Reports, 2023
The presence of a coiled cochlea is a unique feature of the therian inner ear. While some aspects of the cochlea are already known to affect hearing capacities, the full extent of the relationships between the morphology and function of this organ are ...
Joaquin del Rio, Roxana Taszus, Manuela Nowotny, Alexander Stoessel   +3 more
doaj   +1 more source

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

eLife, 2022
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves   +15 more
doaj   +1 more source

Steady streaming as a method for drug delivery to the inner ear

Scientific Reports, 2021
The inner ear, or cochlea, is a fluid-filled organ housing the mechanosensitive hair cells. Sound stimulation is relayed to the hair cells through waves that propagate on the elastic basilar membrane.
Laura Sumner, Jonathan Mestel, Tobias Reichenbach   +2 more
doaj   +1 more source

The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells

Scientific Reports, 2020
Cells of the immune system are present in the adult cochlea and respond to damage caused by noise exposure. However, the types of immune cells involved and their locations within the cochlea are unclear.
Vikrant Rai, Megan B Wood, Hao Feng, N. M. Schabla, Shu Tu, J. Zuo   +5 more
semanticscholar   +1 more source

Macrophages in Noise-Exposed Cochlea: Changes, Regulation and the Potential Role

Aging and Disease, 2020
Acoustic trauma is an important physical factor leading to cochlear damage and hearing impairments. Inflammation responds to this kind of cochlear damage stress.
Weiwei He, Jin-tao Yu, Yu Sun, W. Kong
semanticscholar   +1 more source

Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations

Drug Delivery, 2021
The cochlea’s inaccessibility and complex nature provide significant challenges to delivering drugs and other agents uniformly, safely and efficiently, along the entire cochlear spiral. Large drug concentration gradients are formed along the cochlea when
Samuel M. Flaherty, Ian J. Russell, Andrei N. Lukashkin   +2 more
doaj   +1 more source

Developing Fast, Red-Light Optogenetic Stimulation of Spiral Ganglion Neurons for Future Optical Cochlear Implants

Frontiers in Molecular Neuroscience, 2021
Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration by future optical CIs (oCIs).
Antoine Tarquin Huet, Antoine Tarquin Huet, Tobias Dombrowski, Tobias Dombrowski, Tobias Dombrowski, Vladan Rankovic, Vladan Rankovic, Vladan Rankovic, Anupriya Thirumalai, Anupriya Thirumalai, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +13 more
doaj   +1 more source

Modeling cochlear micromechanics: hypotheses and models

Journal of Bio-X Research, 2019
. The cochlea plays an important role in the mammalian auditory system. Sound-induced cell motion in the cochlea is transformed into electrical signals that are then sent to primary auditory neurons.
Guangjian Ni, Jia Pang, Qi Zheng, Zihao Xu, Baolu Liu, Haiyu Zhang, Dong Ming   +6 more
doaj   +1 more source