Results 11 to 20 of about 107,745 (350)

Variations in microanatomy of the human cochlea

Journal of Comparative Neurology, 2014
The human cochlea shows considerable interindividual variability in size and morphology. In order to develop atraumatic cochlear implant (CI) electrodes, high‐precision details of the variability of human anatomy are required.
Ersin Avci, Thomas Lenarz, Andrej Kral
exaly   +2 more sources

Chronic inflammation – inflammaging – in the ageing cochlea: A novel target for future presbycusis therapy

Ageing Research Reviews, 2017
Robert D Frisina
exaly   +2 more sources

Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance An increasing number of therapeutic strategies are being designed and tested in animal models for numerous forms of hereditary deafness, the most frequent genetic sensorineural disorder.
Philippe Jean, Fabienne Wong Jun Tai, A. Singh-Estivalet, A. Lelli, Cyril Scandola, Sébastien Megharba, Sandrine Schmutz, Solène Roux, S. Mechaussier, Muriel Sudres, Enguerran Mouly, Anne-Valérie Heritier, C. Bonnet, A. Mallet, S. Novault, V. Libri, C. Petit, Nicolas Michalski   +17 more
semanticscholar   +1 more source

In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Ototoxicity is a major side effect of aminoglycoside (AG) antibiotics; however, the mechanism by which this drug enters the cochlea and target hair cells (HCs) is not fully understood.
Jinkyung Kim, A. Ricci
semanticscholar   +1 more source

Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea

Proceedings of the National Academy of Sciences of the United States of America, 2015
Hee Yoon Lee, Jesung Park, Brian E Applegate   +2 more
exaly   +2 more sources

Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging

Scientific Reports, 2021
The human cochlea transforms sound waves into electrical signals in the acoustic nerve fibers with high acuity. This transformation occurs via vibrating anisotropic membranes (basilar and tectorial membranes) and frequency-specific hair cell receptors ...
Hao Li, Luke Helpard, Jonas Ekeroot, S. A. Rohani, N. Zhu, H. Rask-Andersen, H. Ladak, S. Agrawal   +7 more
semanticscholar   +1 more source

Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss

Glia, 2021
Macrophages are abundant in the cochlea; however, their role in hearing loss is not well understood. Insults to the cochlea, such as noise or insertion of a cochlear implant, cause an inflammatory response, which includes activation of tissue‐resident ...
Kate Hough, C. Verschuur, C. Cunningham, T. Newman   +3 more
semanticscholar   +1 more source

Scanning laser optical tomography for in toto imaging of the murine cochlea. [PDF]

PLoS ONE, 2017
The mammalian cochlea is a complex macroscopic structure due to its helical shape and the microscopic arrangements of the individual layers of cells.
Lena Nolte, Nadine Tinne, Jennifer Schulze, Dag Heinemann, Georgios C Antonopoulos, Heiko Meyer, Hans Gerd Nothwang, Thomas Lenarz, Alexander Heisterkamp, Athanasia Warnecke, Tammo Ripken   +10 more
doaj   +1 more source

Application of Curved MPR Algorithm to High Resolution 3 Dimensional T2 Weighted CISS Images for Virtual Uncoiling of Membranous Cochlea as an Aid for Cochlear Morphometry [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: With the use of various surgical techniques, types of implants, the preoperative assessment of cochlear dimensions is becoming increasingly relevant prior to cochlear implantation.
Joish Upendra Kumar, Y Kavitha
doaj   +1 more source

Identification and Characterization of TMEM119-Positive Cells in the Postnatal and Adult Murine Cochlea

Brain Sciences, 2023
Transmembrane protein 119 (TMEM119) is expressed in a subset of resident macrophage cells of the brain and was proposed as a marker for native brain microglia. The presence of cells expressing TMEM119 in the cochlea has not yet been described.
Mohamed Bassiouni, Alina Smorodchenko, Heidi Olze, Agnieszka J. Szczepek   +3 more
doaj   +1 more source