Results 11 to 20 of about 50,225 (239)
Steady streaming as a method for drug delivery to the inner ear
Scientific Reports, 2021 The inner ear, or cochlea, is a fluid-filled organ housing the mechanosensitive hair cells. Sound stimulation is relayed to the hair cells through waves that propagate on the elastic basilar membrane.
Laura Sumner +2 more
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Microstructural interactions contribute to the hotspot in the living cochlea
Current Research in Neurobiology, 2022 The mechanism of the active cochlea relies on a complex interaction between microstructures in the organ of Corti. A significant longitudinal vibration “hotspot” was recently observed in the high-frequency region of the living gerbil cochlea between the ...
Junpei Liu +5 more
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Drug Delivery, 2021 The cochlea’s inaccessibility and complex nature provide significant challenges to delivering drugs and other agents uniformly, safely and efficiently, along the entire cochlear spiral. Large drug concentration gradients are formed along the cochlea when
Samuel M. Flaherty +2 more
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Frontiers in Molecular Neuroscience, 2021 Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration by future optical CIs (oCIs).
Antoine Tarquin Huet +13 more
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Expression and function of scleraxis in the developing auditory system. [PDF]
PLoS ONE, 2013 A study of genes expressed in the developing inner ear identified the bHLH transcription factor Scleraxis (Scx) in the developing cochlea. Previous work has demonstrated an essential role for Scx in the differentiation and development of tendons ...
Zoe F Mann +4 more
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Frontiers in Cellular Neuroscience, 2020 In the past, most inner ear diseases were thought to start with the impairment of the sensory epithelium of the cochlea before subsequently progressing to secondary neural degeneration.
Yutaka Koizumi +3 more
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Synchronization of a Nonlinear Oscillator: Processing the Cf Component of the Echo-Response Signal in the Cochlea of the Mustached Bat [PDF]
, 2003 Cochlear microphonic potential (CM) was recorded from the CF2 region and the sparsely innervated zone (the mustached bat's cochlea fovea) that is specialized for analyzing the Doppler-shifted echoes of the first-harmonic (~61 kHz) of the constant ...
, +5 more
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Analysis of Pharmacokinetics in the Cochlea of the Inner Ear
Frontiers in Pharmacology, 2021 Hearing loss affects >5% of the global population and therefore, has a great social and clinical impact. Sensorineural hearing loss, which can be caused by different factors, such as acoustic trauma, aging, and administration of certain classes of ...
Seishiro Sawamura +20 more
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The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? [PDF]
, 2009 Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons.
Elgoyhen, Ana Belen +2 more
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Expression and localization of α2A-adrenergic receptor in the rat post-natal developing cochlea
European Journal of Histochemistry, 2023 Lots of adrenergic receptors (ARs) are widely present across the auditory pathways and are positioned to affect auditory and vestibular functions. However, noradrenergic regulation in the cochlea has not been well characterized.
Chaoyong Tian +5 more
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