Results 21 to 30 of about 40,867 (265)
Steady streaming as a method for drug delivery to the inner ear
Scientific Reports, 2021 The inner ear, or cochlea, is a fluid-filled organ housing the mechanosensitive hair cells. Sound stimulation is relayed to the hair cells through waves that propagate on the elastic basilar membrane.
Laura Sumner +2 more
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Microstructural interactions contribute to the hotspot in the living cochlea
Current Research in Neurobiology, 2022 The mechanism of the active cochlea relies on a complex interaction between microstructures in the organ of Corti. A significant longitudinal vibration “hotspot” was recently observed in the high-frequency region of the living gerbil cochlea between the ...
Junpei Liu +5 more
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Drug Delivery, 2021 The cochlea’s inaccessibility and complex nature provide significant challenges to delivering drugs and other agents uniformly, safely and efficiently, along the entire cochlear spiral. Large drug concentration gradients are formed along the cochlea when
Samuel M. Flaherty +2 more
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Frontiers in Molecular Neuroscience, 2021 Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration by future optical CIs (oCIs).
Antoine Tarquin Huet +13 more
doaj +1 more source
A feasibility study of functional preservation in craniospinal irradiation with photon for pediatric medulloblastoma. [PDF]
J Appl Clin Med PhysAbstract Background Craniospinal irradiation (CSI) is essential for treating pediatric medulloblastoma (MB) but causes significant long‐term toxicities. Existing dose‐reduction or partial‐sparing strategies improve neurocognitive outcomes but may compromise survival or fail to address other late effects.
Wang K +5 more
europepmc +2 more sources
Expression and function of scleraxis in the developing auditory system. [PDF]
PLoS ONE, 2013 A study of genes expressed in the developing inner ear identified the bHLH transcription factor Scleraxis (Scx) in the developing cochlea. Previous work has demonstrated an essential role for Scx in the differentiation and development of tendons ...
Zoe F Mann +4 more
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Frontiers in Cellular Neuroscience, 2020 In the past, most inner ear diseases were thought to start with the impairment of the sensory epithelium of the cochlea before subsequently progressing to secondary neural degeneration.
Yutaka Koizumi +3 more
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Analysis of Pharmacokinetics in the Cochlea of the Inner Ear
Frontiers in Pharmacology, 2021 Hearing loss affects >5% of the global population and therefore, has a great social and clinical impact. Sensorineural hearing loss, which can be caused by different factors, such as acoustic trauma, aging, and administration of certain classes of ...
Seishiro Sawamura +20 more
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Reconstruction of audio waveforms from spike trains of artificial cochlea models
Frontiers in Neuroscience, 2015 Spiking cochlea models describe the analog processing and spike generation process within the biological cochlea. Reconstructing the audio input from the artificial cochlea spikes is therefore useful for understanding the fidelity of the information ...
Anja eZai +3 more
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Expression and localization of α2A-adrenergic receptor in the rat post-natal developing cochlea
European Journal of Histochemistry, 2023 Lots of adrenergic receptors (ARs) are widely present across the auditory pathways and are positioned to affect auditory and vestibular functions. However, noradrenergic regulation in the cochlea has not been well characterized.
Chaoyong Tian +5 more
doaj +1 more source