Results 51 to 60 of about 73,190 (256)

Three-dimensional imaging of cochlear nerve fibers based on multi-scale resolution

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To establish a standardized research platform for comprehensive imaging of the cochlea and its surrounding tissues through multi-scale resolution three-dimensional (3D) imaging, thereby enabling 3D visualization and analysis of the cochlea ...
CHENG Yaqiong, DU Yiwei, LIU Sidi, JING Dian, WU Hao   +4 more
doaj   +1 more source

Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors [PDF]

, 2001
The deafness caused by early onset hypothyroidism indicates that thyroid hormone is essential for the development of hearing. We investigated the underlying roles of the TRa1 and TRß thyroid hormone receptors in the auditory system using receptor ...
Forrest, Douglas, Goodyear, Richard, Kelley, Matthew W, Lisoukov, Igor, Ng, Lily, Oliver, Dominik, Richardson, Guy, Rüsch, Alfons, Vennström, Björn   +8 more
core   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science
The current understanding of the human auditory system has been primarily based on studies using animal and cellular models. Organoids have been used to simulate cochlear structures and replicate cochlear functions.
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
doaj   +1 more source

Culturing Neurons on MEMS Fabricated P(VDF-TrFE) Films for Implantable Artificial Cochlea

Journal of Biomechanical Science and Engineering, 2010
In this paper, we report an in vitro study on the biocompatibility of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) films for the implantable artificial cochlea.
Hirofumi SHINTAKU, Takashi TATENO, Nobuyoshi TSUCHIOKA, Harto TANUJAYA, Takayuki NAKAGAWA, Juichi ITO, Satoyuki KAWANO   +6 more
doaj   +1 more source

Feasibility study of a hand guided robotic drill for cochleostomy [PDF]

, 2014
The concept of a hand guided robotic drill has been inspired by an automated, arm supported robotic drill recently applied in clinical practice to produce cochleostomies without penetrating the endosteum ready for inserting cochlear electrodes. The smart
Brett, P, Coulson, C, Du, X, Proops, D, Reid, A, Zoka-Assadi, M   +5 more
core   +6 more sources

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Biophysical parameters modification could overcome essential hearing gaps. [PDF]

PLoS Computational Biology, 2008
A majority of hearing defects are due to malfunction of the outer hair cells (OHCs), those cells within the mammalian hearing sensor (the cochlea) that provide an active amplification of the incoming signal.
A Kern, C Heid, W-H Steeb, N Stoop, R Stoop   +4 more
doaj   +1 more source

Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells. [PDF]

, 2020
The mammalian cochlea relies on active electromotility of outer hair cells (OHCs) to resolve sound frequencies. OHCs use ionic channels and somatic electromotility to achieve the process.
Chiamvimonvat, Nipavan, Kim, Hyo Jeong, Ledford, Hannah A, Lee, Jeong H, Park, Seojin, Perez-Flores, Maria C, Rabbitt, Richard D, Sihn, Choong-Ryoul, Timofeyev, Valeriy, Wang, Wenying, Yamoah, Ebenezer N, Yarov-Yarovoy, Vladimir, Zhang, Xiao-Dong   +12 more
core   +1 more source

Nanoparticle drug delivery systems for inner ear therapy: An overview [PDF]

, 2017
open7noembargoed_20180701Valente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, AlessandroValente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini,
Astolfi, Laura, Chicca, Milvia, DANTI, SERENA, Franceschini, Valeria, Martini, Alessandro, Simoni, Edi, Valente, Filippo   +6 more
core   +2 more sources