Results 61 to 70 of about 66,419 (330)
Advanced Science, EarlyView.Data from a prospective cohort with 112 auditory brainstem implant users are analyzed. Younger age at implantation (<3 years), less severe inner‐ear malformation (common cavity, cochlear aplasia, and hypoplasia), and more intraoperative eABR evoked electrodes (≥60%) are associated with better hearing and speech outcomes.
Yu Zhang +11 more
wiley +1 more source
Purinergic Signalling in the Cochlea
International Journal of Molecular Sciences, 2022 The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous physiological responses by activating P2 receptors in sensory, supporting and neural tissues.
Srdjan M. Vlajkovic, Peter R. Thorne
openaire +2 more sources
Advanced Science, EarlyView.AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang +8 more
wiley +1 more source
eLife, 2022 Before hearing onset (postnatal day 12 in mice), inner hair cells (IHCs) spontaneously fire action potentials, thereby driving pre-sensory activity in the ascending auditory pathway.
Alena Maul +6 more
doaj +1 more source
Scientific Reports, 2016 Hearing impairment is the most frequent sensory deficit in humans. Deafness genes, which harbor pathogenic mutations that have been identified in families with hereditary hearing loss, are commonly expressed in the auditory end organ or the cochlea and ...
M. Hosoya +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen +8 more
wiley +1 more source
Rapid mechanical stimulation of inner-ear hair cells by photonic pressure
eLife, 2021 Hair cells, the receptors of the inner ear, detect sounds by transducing mechanical vibrations into electrical signals. From the top surface of each hair cell protrudes a mechanical antenna, the hair bundle, which the cell uses to detect and amplify ...
Sanjeewa Abeytunge +3 more
doaj +1 more source
Journal of Neuroscience, 2017 Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and humans. The release of ATP from connexin hemichannels in cochlear nonsensory cells
Stuart L. Johnson +8 more
semanticscholar +1 more source
Masculinization of the mammalian cochlea [PDF]
Hearing Research, 2009 Otoacoustic emissions (OAEs) differ between the sexes in humans, rhesus and marmoset monkeys, and sheep. OAEs also are different in a number of special populations of humans. Those basic findings are reviewed and discussed in the context of possible prenatal-androgen effects on the auditory system.
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A Gradient of Single-Channel Conductance in the Cochlea [PDF]
Neuron, 2003 AbstractFrequency tuning in the vertebrate cochlea requires a continuously varying amplifier in auditory hair cells. In this issue of Neuron, Ricci et al. show that the mechanosensitive transduction channel, a possible amplifier component, has a single-channel conductance that increases systematically along the frequency axis of the turtle cochlea.
Eunice L.M. Cheung, David P. Corey
openaire +3 more sources