Results 111 to 120 of about 1,007,768 (261)
An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda +6 more
wiley +1 more source
Frontiers in Immunology, 2019 The loss of sensory hair cells in the cochlea is the major cause of sensorineural hearing loss, and inflammatory processes and immune factors in response to cochlear damage have been shown to induce hair cell apoptosis.
Yanping Zhang +14 more
doaj +1 more source
Speech Recognition Deficits in Presbyacusis: Links to Cortical Structural and Functional Alterations
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective To characterize speech recognition in presbyacusis and its associated neurophysiological and cortical structural features, and to explore structure‐function‐behavior relationships within the presbyacusis phenotype. Methods Thirty elderly patients with presbyacusis(HI) and thirty‐three healthy young controls(NH) completed a behavioral
Xiao‐Qian Ren +8 more
wiley +1 more source
Schematic diagram demonstrated the protective mechanism of SAL in cochlear cultures against GM-induced hair cells injury.
Xinyi Guo (3755509) +5 more
core +1 more source
Drug Delivery, 2018 Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need.
Ao Li +10 more
doaj +1 more source
eLife, 2014 Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions remain poorly understood.
Guoqiang Wan +4 more
doaj +1 more source
Unveiling Otolith Mystery: Contemporary Testing Approaches and Their Clinical Significance
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective Otolith is a critical component of the peripheral vestibular system responsible for detecting linear acceleration. Dysfunction of the otolith organs can lead to vertigo, balance disturbances, and gaze instability. By elucidating the physiological foundations and evaluating both current and emerging methods for assessing otolith ...
Shun Zhou +16 more
wiley +1 more source
Fluid coupling between the elements in a discrete model of cochlear mechanics
, 2010 When analysing the coupled mechanics of the cochlea, due to the interaction between fluid coupling and basilar membrane motion, it is convenient to divide the cochlea longitudinally into a discrete number of sections.
Ni, G., Elliott, S.J., Lineton, B.
core +1 more source
Neuroscience ResearchSpiral ganglion neurons (SGNs) transmit sound signals received by hair cells to the auditory center to produce hearing. The quantity and function are important for maintaining normal hearing function. Limited by the regenerative capacity, SGNs are unable
Gui Fei +10 more
doaj +1 more source
Association Characteristics and Potential Mechanisms of Aging, Gut Microbiota, and Hearing Loss
Integrative Zoology, EarlyView.The study found that aging leads to unchanged gut microbiota alpha diversity but an increase in Bacteroidetes and a decrease in Firmicutes at the phylum level, with specific genera, species, and functional pathways co‐associated with aging and hearing loss. Through constructing a microbe‐metabolite network, it revealed the mechanism by which protective
Cheng Cheng +7 more
wiley +1 more source