Results 61 to 70 of about 1,007,768 (261)

Surgical Methods and Auditory Outcomes of Cochlear Implantation in Cochlear Ossification

, 2022
Background: The aim of this study was to evaluate the surgical and auditory outcomes of cochlear implantation in patients with cochlear ossification. Methods: This study comprised 54 patients with cochlear ossification who underwent cochlear implantation
Tokat, Taskin, Ergul Basaran Bozkurt, Tolgahan Catli, Olgun, Levent, Taskin Tokat, Basaran Bozkurt, Ergul, Levent Olgun, Catli, Tolgahan, Bozkurt, Ergul Basaran   +8 more
core   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Comparisons of unilateral and bilateral cochlear implantation for children: spatial listening skills and quality of life [PDF]

, 2010
Recently, controversy in the care of severely-profoundly deaf children has centred on whether they should be provided with bilateral cochlear implants (two implants, one in each ear) rather than a unilateral cochlear implant (one implant in one ear ...
Lovett, Rosemary Elizabeth Susan
core   +4 more sources

Inhibition of TLR4 mitigates sensorineural hearing loss resulting from cochlear inflammation

Molecular Medicine
Background Inflammation is a principal cause of sensorineural hearing loss resulting from cochlear injury. However, current research investigating the mechanisms of sensorineural inflammatory injury remains inadequate.
Jintao Lou, Fan Wu, Wei Liu, Rui Hu, Wuhui He, Yisi Feng, Yan Huang, Jia Guo, Jingman Deng, Zhen Zhao, Zhigang Zhang, Yu Si   +11 more
doaj   +1 more source

Pharmacological inhibition of cochlear mitochondrial respiratory chain induces secondary inflammation in the lateral wall: a potential therapeutic target for sensorineural hearing loss. [PDF]

PLoS ONE, 2014
Cochlear lateral wall has recently been reported as a common site of inflammation, yet precise molecular mechanisms of the inflammatory responses remain elucidated. The present study examined the inflammatory responses in the lateral wall following acute
Masato Fujioka, Yasuhide Okamoto, Seiichi Shinden, Hirotaka James Okano, Hideyuki Okano, Kaoru Ogawa, Tatsuo Matsunaga   +6 more
doaj   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Dietary Zinc Glycine Supplementation Attenuates Aging-Driven Cochlear Hair Cell Oxidative Injury and Hearing Loss [PDF]

Nutrients
Xue Bai, Kai-Lang Zhou, Wen-Hui Hu, Li Sheng Fu, Sha-Sha Sun, Yi-Meng Yuan, Kai Xu, Yue-Hui Liu   +7 more
europepmc   +2 more sources

c-Myb protects cochlear hair cells from cisplatin-induced damage via the PI3K/Akt signaling pathway

Cell Death Discovery, 2022
The transcription factor c-Myb is vital for cell survival, proliferation, differentiation, and apoptosis. We have previously reported that c-Myb knockdown exacerbates neomycin-induced damage to cochlea cells. However, the function and regulation of c-Myb
Chuan Bu, Lei Xu, Yuechen Han, Man Wang, Xue Wang, Wenwen Liu, Renjie Chai, Haibo Wang   +7 more
doaj   +1 more source

Analysis of ceiling effects occurring with speech recognition tests in adult cochlear-implanted patients [PDF]

, 2004
This article presents a simple method of analysing speech test scores which are biased through ceiling effects. Eighty postlingually deafened adults implanted with a MED-EL COMBI 40/40+ cochlear implant (CI) were administered a numbers test and a ...
Ziese, Michael, Anderson, Ilona, Weichbold, Viktor, D'Haese, Patrick, Esser, Barbara, Helms, Jan, Müller, Joachim, Specht, Hellmut von, Baumann, Uwe, Schön, Franz   +9 more
core   +1 more source

Statistical shape modeling of the human inner ear through micro‐computed tomography imaging

The Anatomical Record, EarlyView.
In this study, 54 cadaveric temporal bone specimens underwent high‐resolution micro‐CT imaging. Images were semi‐automatically segmented and converted to 3D surface mesh models for morphological measurement and analysis. Statistical shape models were created for the inner ear, cochlea, and vestibular system, as well as for sex‐ and side‐based subgroups.
Carmine Spedaliere, Alexandra Vaupotic, Jaehyun Hwang, Khalil Husein, Mustafa Hafidh, Kyle Rioux, S. Alireza Rohani, Sumit K. Agrawal, Hanif M. Ladak   +8 more
wiley   +1 more source