Results 51 to 60 of about 1,007,768 (261)

Antioxidative stress-induced damage in cochlear explants

Journal of Otology, 2020
The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress.
Dalian Ding, Jianghui Zhang, Fang Liu, Peng Li, Weidong Qi, Yazhi Xing, Haibo Shi, Haiyan Jiang, Hong Sun, Shankai Yin, Richard Salvi   +10 more
doaj   +1 more source

Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage

Neural Plasticity, 2016
It is increasingly appreciated that cochlear pathology is accompanied by adaptive responses in the central auditory system. The cause of cochlear pathology varies widely, and it seems that few commonalities can be drawn.
Yi Zhao, Qiang Song, Xinyi Li, Chunyan Li   +3 more
doaj   +1 more source

Orthographic influences, vocabulary development and phonological awareness in deaf children who use cochlear implants [PDF]

, 2009
In the current study, we explore the influence of orthographic knowledge on phonological awareness in children with cochlear implants and compare developmental associations to those found for hearing children matched for word reading level or ...
Rajput, Kaukab, James, Deborah, Goswami, Usha, Brinton, Julie   +3 more
core   +1 more source

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

Modeling the Measurements of Cochlear Microcirculation and Hearing Function after Loud Noise [PDF]

, 2011
Objective: Recent findings support the crucial role of microcirculatory disturbance and ischemia for hearing impairment especially after noise-induced hearing loss (NIHL).
Canis, Martin, Arpornchayanon, Warangkana, Strieth, Sebastian, Markus Suckfuell, Sebastian Strieth, Bernhard Olzowy, Olzowy, Bernhard, Suckfuell, Markus, Ihler, Fritz, Martin Canis, Warangkana Arpornchayanon, Fritz Ihler   +11 more
core   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Multiplex immunohistochemistry reveals cochlear macrophage heterogeneity and local auditory nerve inflammation in cisplatin-induced hearing loss

Frontiers in Neurology, 2022
Inner ear macrophages play a vital role in cochlear homeostasis. Recent studies have demonstrated the existence of macrophages at different sites of the cochlea, with increased cochlear infiltration as an inflammatory response mechanism to injury ...
Mai Mohamed Bedeir, Yuzuru Ninoyu, Takashi Nakamura, Takahiro Tsujikawa, Shigeru Hirano   +4 more
doaj   +1 more source

The role of diet in vulnerability to noise-induced cochlear injury and hearing loss [PDF]

The Journal of the Acoustical Society of America, 2019
The influence of dietary nutrient intake on the onset and trajectory of hearing loss during aging and in mediating protection from challenges such as noise is an important relationship yet to be fully appreciated. Dietary intake provides essential nutrients that support basic cellular processes related to influencing cellular stress response, immune ...
Christopher, Spankovich, Colleen G, Le Prell   +1 more
openaire   +2 more sources

UHRF1-induced connexin26 methylation is involved in hearing damage triggered by intermittent hypoxia in neonatal rats

Open Medicine, 2023
Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) promotes the maintenance of established patterns of DNA methylation in mammalian cells.
Zhang Xingang, Zheng Jishan, Xu Huiqing, Ma Zhaoxin   +3 more
doaj   +1 more source