Results 31 to 40 of about 1,007,768 (261)

Sox2 overexpression alleviates noise-induced hearing loss by inhibiting inflammation-related hair cell apoptosis

Journal of Neuroinflammation, 2022
Background The transcription factor Sox2 plays important roles in the developmental processes of multiple organs and tissues. However, whether Sox2 can protect mature or terminally differentiated cells against injury is still unknown.
Diyan Chen, Gaogan Jia, Yanping Zhang, Huanyu Mao, Liping Zhao, Wenyan Li, Yan Chen, Yusu Ni   +7 more
doaj   +1 more source

Glucocorticoid Treatment for Cochlear Ischemic and Acoustic Injuries

Nippon Jibiinkoka Gakkai Kaiho, 2010
The effect of glucocorticoids on sensorineural hearing loss of sudden onset remains to be controversial although glucocorticoids have been used for treatment of sudden sensorineural hearing loss. We review recent findings about the effect of glucocorticoids on cochlear ischemic and acoustic injuries obtained from animal experiments.
Tabuchi, Keiji, Hara, Akira
openaire   +3 more sources

Inhibition of the Adenosine A_2A Receptor Mitigates Excitotoxic Injury in Organotypic Tissue Cultures of the Rat Cochlea

Cells, 2019
The primary loss of cochlear glutamatergic afferent nerve synapses due to noise or ageing (cochlear neuropathy) often presents as difficulties in speech discrimination in noisy conditions (hidden hearing loss (HHL)).
Belinda RX Han, Shelly CY Lin, Kristan Espinosa, Peter R Thorne, Srdjan M Vlajkovic   +4 more
doaj   +1 more source

Lipidic nanocapsule drug delivery : neuronal protection for cochlear implant optimization [PDF]

, 2012
Objective: Sensorineural hearing loss leads to the progressive degeneration of spiral ganglion cells (SGC). Next to postoperative fibrous tissue growth, which should be suppressed to assure a close nerve–electrode interaction, the density of healthy SGC ...
Meyer, Hartwig, Scheper, Verena, Saulnier, Patrick, F. Fouchet, Fouchet, Florian, Stöver, Timo, P. Saulnier, H. Meyer, W. Bäumer, V. Scheper, Bastiat, Guillaume, Bäumer, Wolfgang, Lenarz, Thomas, T. Stöver, T. Lenarz, G. Bastiat   +15 more
core   +1 more source

Transforming growth factor β1 inhibition protects from noise-induced hearing loss

Frontiers in Aging Neuroscience, 2015
Excessive exposure to noise damages the principal cochlear structures leading to hearing impairment. Inflammatory and immune responses are central mechanisms in cochlear defensive response to noise but, if unregulated, they contribute to inner ear damage
Silvia eMurillo-Cuesta, Silvia eMurillo-Cuesta, Silvia eMurillo-Cuesta, Lourdes eRodríguez-de La Rosa, Lourdes eRodríguez-de La Rosa, Lourdes eRodríguez-de La Rosa, Julio eContreras, Julio eContreras, Julio eContreras, Adelaida M Celaya, Adelaida M Celaya, Guadalupe eCamarero, Guadalupe eCamarero, Guadalupe eCamarero, Teresa eRivera, Teresa eRivera, Teresa eRivera, Isabel eVarela-Nieto, Isabel eVarela-Nieto, Isabel eVarela-Nieto   +19 more
doaj   +1 more source

EVALUATION OF THE RESULTS OF DIFFERENT PROCEDURES IN COCHLEAR IMPLANTATION. [PDF]

Zagazig University Medical Journal, 2014
Background: The cochlear implantation has radically changed the outlook for profoundly deaf adults and children. The cochlear implant can provide sufficient hearing sensations to enable most severely or profoundly deafened persons to continue ...
Alaa El-Din El-Feky, Ezz El-Din El Shiekh, Hassan Wahba   +2 more
doaj   +3 more sources

Anatomical Characteristics of the Facial Nerve in Patients With Cochlear Hypoplasia. [PDF]

World J Otorhinolaryngol Head Neck Surg
ABSTRACT Objective To quantitatively characterize the spatial relationships between intratemporal facial nerve segments and key cochlear implantation (CI) landmarks in cochlear hypoplasia (CH), and to compare these features with age‐matched CI recipients with normal inner ear anatomy, thereby informing preoperative planning and facial nerve ...
Xue SJ, Wei XM, Chen B, Kong Y, Li YX.
europepmc   +2 more sources

Active and Adequate Exposure of the Facial Nerve and Chorda Tympani Nerve to Improve the Safety of Cochlear Implantation

Ear, Nose & Throat Journal, 2021
Background: The posterior tympanum approach of cochlear implantation is easy to damage the facial nerve and cord tympanic nerve. Therefore, we need to improve the safety of cochlear implantation.
Ling Lu MM, Maohua Wang MM, Jianfei Dong MM, Chuanyao Lin BM, Chenjie Yu MD, Xiaoyun Qian MD, Xia Gao MD   +6 more
doaj   +1 more source

Modelling Cochlear mechanics [PDF]

, 2014
The cochlea plays a crucial role in mammal hearing. The basic function of the cochlea is to map sounds of different frequencies onto corresponding characteristic positions on the basilar membrane (BM).
Ni, Guangjian, Ayat, Mohammad, Teal, Paul D., Elliott, Stephen J.   +3 more
core   +1 more source

Interleukin-10 Attenuates Hypochlorous Acid-Mediated Cytotoxicity to HEI-OC1 Cochlear Cells

Frontiers in Cellular Neuroscience, 2017
Inflammatory reaction plays a crucial role in the pathophysiology of acquired hearing loss such as ototoxicity and labyrinthitis. In our earlier work, we showed the pivotal role of otic fibrocytes in cochlear inflammation and the critical involvement of ...
Martin Mwangi, Sung-Hee Kil, David Phak, Hun Yi Park, David J. Lim, Raekil Park, Sung K. Moon   +6 more
doaj   +1 more source