Results 31 to 40 of about 12,941 (217)
Nicotine induced ototoxicity in rat cochlear organotypic cultures
Translational Neuroscience, 2021 Epidemiological evidence has shown that smoking is associated with an increased risk of hearing loss. However, the underlying mechanisms regarding the impact of nicotine on the cochlea remain unclear. This study aimed to investigate the cytotoxic effects
Zhao Yi +7 more
doaj +1 more source
Antioxidative stress-induced damage in cochlear explants
Journal of Otology, 2020 The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress.
Dalian Ding +10 more
doaj +1 more source
Recent findings and emerging questions in cochlear noise injury [PDF]
Hearing Research, 2008 The lives of an estimated 10 million people in the United States are impacted by debilitating cochlear noise injury acquired in leisure or occupational settings (Kopke et al., 2007). Although noise injury has been intensively studied for decades, the only clinically successful preventive measure against noise-induced hearing loss (NIHL) remains a ...
openaire +2 more sources
Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage
Neural Plasticity, 2016 It is increasingly appreciated that cochlear pathology is accompanied by adaptive responses in the central auditory system. The cause of cochlear pathology varies widely, and it seems that few commonalities can be drawn.
Yi Zhao +3 more
doaj +1 more source
Frontiers in Neurology, 2022 Inner ear macrophages play a vital role in cochlear homeostasis. Recent studies have demonstrated the existence of macrophages at different sites of the cochlea, with increased cochlear infiltration as an inflammatory response mechanism to injury ...
Mai Mohamed Bedeir +4 more
doaj +1 more source
Open Medicine, 2023 Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1) promotes the maintenance of established patterns of DNA methylation in mammalian cells.
Zhang Xingang +3 more
doaj +1 more source
A Geometrically Transient Platform for Bioelectronic Implants
Advanced Materials, EarlyView.Minimally invasive bioelectronic implants often compromise performance for smaller sizes. To resolve this optimization dilemma, a wireless bioelectronic implant with a transient geometry is introduced (MiFi). The origami‐inspired device miniaturizes up to sixfold for syringe insertion and autonomously unfolds post‐implantation.
Selin Olenik +13 more
wiley +1 more source
Pharmacological inhibition of cochlear mitochondrial respiratory chain induces secondary inflammation in the lateral wall: a potential therapeutic target for sensorineural hearing loss. [PDF]
PLoS ONE, 2014 Cochlear lateral wall has recently been reported as a common site of inflammation, yet precise molecular mechanisms of the inflammatory responses remain elucidated. The present study examined the inflammatory responses in the lateral wall following acute
Masato Fujioka +6 more
doaj +1 more source
Biointegrated Battery‐Based Electroceuticals
Advanced Materials, EarlyView.Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou +6 more
wiley +1 more source
Hearing Loss After Activation of Hearing Preservation Cochlear Implants Might Be Related to Afferent Cochlear Innervation Injury [PDF]
Otology & Neurotology, 2015 Characterize hearing loss (HL) after hearing preservation cochlear implantation and determine the association between high charge electrical stimulation (ES) and late loss of acoustic hearing.A retrospective cohort analysis of all hearing preservation implantees at our center (n = 42) assayed HL as a function of maximum charge.
Jonathan C, Kopelovich +6 more
openaire +2 more sources