Results 11 to 20 of about 12,941 (217)
Pravastatin Administration Alleviates Kanamycin-Induced Cochlear Injury and Hearing Loss. [PDF]
Int J Mol Sci, 2022 The effect of statins on aminoglycoside-induced ototoxicity is controversial. This study aimed to explore the role of pravastatin (PV) in kanamycin-induced hearing loss in rats. Adult rats were intraperitoneally treated with 20 mg/kg/day of kanamycin (KM) for 10 days.
Lee CH, Jeon J, Lee SM, Kim SY.
europepmc +3 more sources
Transcriptional response to mild therapeutic hypothermia in noise-induced cochlear injury. [PDF]
Front Neurosci, 2023 IntroductionPrevention or treatment for acoustic injury has been met with many translational challenges, resulting in the absence of FDA-approved interventions. Localized hypothermia following noise exposure mitigates acute cochlear injury and may serve as a potential avenue for therapeutic approaches.
Rincon Sabatino S +5 more
europepmc +4 more sources
Purinergic Signaling and Cochlear Injury-Targeting the Immune System? [PDF]
Int J Mol Sci, 2019 Hearing impairment is the most common sensory deficit, affecting more than 400 million people worldwide. Sensorineural hearing losses currently lack any specific or efficient pharmacotherapy largely due to the insufficient knowledge of the pathomechanism. Purinergic signaling plays a substantial role in cochlear (patho)physiology.
Köles L +3 more
europepmc +5 more sources
Trimethyltin ototoxicity: evidence for a cochlear site of injury [PDF]
Hearing Research, 1986 The environmental contaminant, trimethyltin (TMT), produces a profound elevation in tone intensity necessary to inhibit the acoustic startle reflex in laboratory animals which recovers over a prolonged period except at very high frequencies. The recovery that is observed does not begin until 3 to 5 weeks after a single acute administration depending ...
Fechter, Laurence D. +2 more
openaire +3 more sources
Journal of Otology, 2022 Preservation of low-frequency residual hearing is very important for combined electro-acoustic stimulation after cochlear implantation. However, in clinical practice, loss of low-frequency residual hearing often occurs after cochlear implantation and its
Juanjuan Gao, Haijin Yi
doaj +1 more source
Impulse noise injury prediction based on the cochlear energy [PDF]
Hearing Research, 2016 The current impulse noise criteria for the protection against impulse noise injury do not incorporate an objective measure of hearing protection. A new biomechanically-based model has been developed based on improvement of the Auditory Hazard Assessment Algorithm for the Human (AHAAH) using the integrated cochlear energy (ICE) as the damage risk ...
Brissi, Zagadou +3 more
openaire +2 more sources
Journal of Neuroinflammation, 2022 Background The transcription factor Sox2 plays important roles in the developmental processes of multiple organs and tissues. However, whether Sox2 can protect mature or terminally differentiated cells against injury is still unknown.
Diyan Chen +7 more
doaj +1 more source
Glucocorticoid Treatment for Cochlear Ischemic and Acoustic Injuries
Nippon Jibiinkoka Gakkai Kaiho, 2010 The effect of glucocorticoids on sensorineural hearing loss of sudden onset remains to be controversial although glucocorticoids have been used for treatment of sudden sensorineural hearing loss. We review recent findings about the effect of glucocorticoids on cochlear ischemic and acoustic injuries obtained from animal experiments.
Tabuchi, Keiji, Hara, Akira
openaire +3 more sources
Cells, 2019 The primary loss of cochlear glutamatergic afferent nerve synapses due to noise or ageing (cochlear neuropathy) often presents as difficulties in speech discrimination in noisy conditions (hidden hearing loss (HHL)).
Belinda RX Han +4 more
doaj +1 more source
EVALUATION OF THE RESULTS OF DIFFERENT PROCEDURES IN COCHLEAR IMPLANTATION. [PDF]
Zagazig University Medical Journal, 2014 Background: The cochlear implantation has radically changed the outlook for profoundly deaf adults and children. The cochlear implant can provide sufficient hearing sensations to enable most severely or profoundly deafened persons to continue ...
Alaa El-Din El-Feky +2 more
doaj +3 more sources