Use of Proteomic Imaging Coupled With Transcriptomic Analysis to Identify Biomolecules Responsive to Cochlear Injury [PDF]
Frontiers in Molecular Neuroscience, 2018 Exposure to noise or ototoxic agents can result in degeneration of cells in the sensory epithelium and auditory nerve, as well as non-sensory cells of the cochlear lateral wall.
Kenyaria V. Noble +7 more
doaj +2 more sources
Trimethyltin ototoxicity: evidence for a cochlear site of injury [PDF]
Hearing Research, 1986 The environmental contaminant, trimethyltin (TMT), produces a profound elevation in tone intensity necessary to inhibit the acoustic startle reflex in laboratory animals which recovers over a prolonged period except at very high frequencies. The recovery that is observed does not begin until 3 to 5 weeks after a single acute administration depending ...
Fechter, Laurence D. +2 more
openaire +5 more sources
Impulse noise injury prediction based on the cochlear energy [PDF]
Hearing Research, 2016 The current impulse noise criteria for the protection against impulse noise injury do not incorporate an objective measure of hearing protection. A new biomechanically-based model has been developed based on improvement of the Auditory Hazard Assessment Algorithm for the Human (AHAAH) using the integrated cochlear energy (ICE) as the damage risk ...
Brissi, Zagadou +3 more
openaire +3 more sources
meningitis following head injury after cochlear implantation: A case report [PDF]
European Journal of Inflammation, 2020 Bacterial meningitis is a rare event in children with cochlear implants. A 7-year-old child who underwent cochlear implantation (CI) for the right ear 6 years ago was admitted to our hospital with the chief complaint of intermittent fever and headache ...
Zhanfeng Yan +7 more
doaj +2 more sources
Advances and Challenges in Pharmaceutical Therapies to Prevent and Repair Cochlear Injuries From Noise [PDF]
Frontiers in Cellular Neuroscience, 2019 Noise induces a broad spectrum of pathological injuries to the cochlea, reflecting both mechanical damage to the delicate architecture of the structures of the organ of Corti and metabolic damage within the organ of Corti and lateral wall tissues. Unlike
Eric C. Bielefeld +2 more
doaj +2 more sources
Adenosine amine congener mitigates noise-induced cochlear injury [PDF]
Purinergic Signalling, 2010 Hearing loss from noise exposure is a leading occupational disease, with up to 5% of the population at risk world-wide. Here, we present a novel purine-based pharmacological intervention that can ameliorate noise-induced cochlear injury. Wistar rats were exposed to narrow-band noise (8-12 kHz, 110 dB SPL, 2-24 h) to induce cochlear damage and permanent
Srdjan M, Vlajkovic +6 more
openaire +4 more sources
Hearing Loss After Activation of Hearing Preservation Cochlear Implants Might Be Related to Afferent Cochlear Innervation Injury [PDF]
Otology & Neurotology, 2015 Characterize hearing loss (HL) after hearing preservation cochlear implantation and determine the association between high charge electrical stimulation (ES) and late loss of acoustic hearing.A retrospective cohort analysis of all hearing preservation implantees at our center (n = 42) assayed HL as a function of maximum charge.
Jonathan C, Kopelovich +6 more
openaire +4 more sources
Sestrin 2 Deficiency Exacerbates Noise-Induced Cochlear Injury Through Inhibiting ULK1/Parkin-Mediated Mitophagy. [PDF]
Antioxid Redox Signal, 2023 Li Y +16 more
europepmc +3 more sources
CellsThe cochlea is susceptible to damage from ototoxic agents such as cisplatin, yet the mechanisms underlying cochlear injury remain incompletely understood.
Bin Zeng +6 more
doaj +2 more sources
Synaptic zinc plasticity shapes adaptive and maladaptive cortical plasticity following cochlear injury. [PDF]
Sci AdvKumar M +5 more
europepmc +2 more sources