The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury [PDF]
Frontiers in Cell and Developmental Biology, 2021 Macrophages are the main intrinsic immune cells in the cochlea; they can be activated and play a complicated role after cochlear injury. Many studies have shown that the number of macrophages and their morphological characteristics within the major ...
Qin Wang, Xiaolong Fu, Renjie Chai
exaly +8 more sources
Transcriptional response to mild therapeutic hypothermia in noise-induced cochlear injury. [PDF]
Front Neurosci, 2023 IntroductionPrevention or treatment for acoustic injury has been met with many translational challenges, resulting in the absence of FDA-approved interventions. Localized hypothermia following noise exposure mitigates acute cochlear injury and may serve as a potential avenue for therapeutic approaches.
Rincon Sabatino S +5 more
europepmc +5 more sources
Pravastatin Administration Alleviates Kanamycin-Induced Cochlear Injury and Hearing Loss. [PDF]
Int J Mol Sci, 2022 The effect of statins on aminoglycoside-induced ototoxicity is controversial. This study aimed to explore the role of pravastatin (PV) in kanamycin-induced hearing loss in rats. Adult rats were intraperitoneally treated with 20 mg/kg/day of kanamycin (KM) for 10 days.
Lee CH, Jeon J, Lee SM, Kim SY.
europepmc +5 more sources
Prestin as a potential biomarker for cochlear injury: Current evidence and future directions. [PDF]
Eur Arch OtorhinolaryngolPrestin has been identified as a potential biomarker for cochlear damage and consequent ototoxicity. Although several preclinical and clinical studies have investigated prestin, a comprehensive overview of the evidence regarding its diagnostic value across different types of auditory damage and its use for cancer treatment-related ototoxicity is ...
Streefkerk N +8 more
europepmc +5 more sources
Cochlear injury and adaptive plasticity of the auditory cortex [PDF]
Frontiers in Aging Neuroscience, 2015 Growing evidence suggests that cochlear stressors as noise exposure and aging can induce homeostatic/maladaptive changes in the central auditory system from the brainstem to the cortex.
ANNA R. eFETONI +3 more
doaj +8 more sources
Purinergic Signaling and Cochlear Injury-Targeting the Immune System? [PDF]
Int J Mol Sci, 2019 Hearing impairment is the most common sensory deficit, affecting more than 400 million people worldwide. Sensorineural hearing losses currently lack any specific or efficient pharmacotherapy largely due to the insufficient knowledge of the pathomechanism. Purinergic signaling plays a substantial role in cochlear (patho)physiology.
Köles L +3 more
europepmc +7 more sources
Long-Term Cochlear Implantation Outcomes in Patients Following Head Injury [PDF]
Laryngoscope Investigative Otolaryngology, 2020 AbstractObjectiveIn cases of a severe to profound sensorineural hearing loss following head injury, the cochlear implant (CI) is the primary option for auditory rehabilitation. Few studies, however, have investigated long‐term CI outcomes in patients following head trauma, including those without temporal bone fracture (TBF).
Rory J Lubner +2 more
exaly +5 more sources
A Non-Linear Ototoxic Response to Cisplatin Is Associated with Autophagy and PTEN/PI3K/AKT Signaling in Cochlear Hair Cells and Spiral Ganglion Neurons. [PDF]
BiomedicinesBackground: Cisplatin-induced ototoxicity is generally considered dose-dependent. However, cellular adaptive responses under severe cisplatin stress remain incompletely understood.
Li Y +8 more
europepmc +2 more sources
Prestin as a context-dependent biomarker of outer hair cell stress: Integrating preclinical and clinical evidence. [PDF]
Tzu Chi Med JThe early detection of hearing loss remains a major clinical challenge. In many patients, once functional changes become evident on pure-tone audiometry, their recovery is limited.
Hsieh CY +6 more
europepmc +2 more sources
Hippo–YAP/TAZ signaling in inner ear development, injury, and regeneration: evidence synthesis and the biomechanical brake hypothesis [PDF]
Front Cell Dev BiolSensorineural hearing loss in mammals is essentially irreversible. Mature cochlear hair cells, once lost, do not regenerate. Non-mammalian vertebrates retain this ability, but in the mammalian organ of Corti, supporting cells lose their proliferative and
Guan D, Liu X, Zhang X, Zhang J, Xie H.
europepmc +2 more sources