The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury [PDF]
Frontiers in Cell and Developmental Biology, 2021 Macrophages are the main intrinsic immune cells in the cochlea; they can be activated and play a complicated role after cochlear injury. Many studies have shown that the number of macrophages and their morphological characteristics within the major ...
Yuan Zhang +12 more
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Cochlear injury and adaptive plasticity of the auditory cortex [PDF]
Frontiers in Aging Neuroscience, 2015 Growing evidence suggests that cochlear stressors as noise exposure and aging can induce homeostatic/maladaptive changes in the central auditory system from the brainstem to the cortex.
ANNA R. eFETONI +3 more
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Use of Proteomic Imaging Coupled With Transcriptomic Analysis to Identify Biomolecules Responsive to Cochlear Injury [PDF]
Frontiers in Molecular Neuroscience, 2018 Exposure to noise or ototoxic agents can result in degeneration of cells in the sensory epithelium and auditory nerve, as well as non-sensory cells of the cochlear lateral wall.
Kenyaria V. Noble +7 more
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Cochlear neural functional competence: an integrative transcriptomic module analysis of excitability, plasticity and microenvironmental support programs [PDF]
Frontiers in Cellular NeuroscienceBackgroundCochlear implants (CIs) restore hearing by directly stimulating spiral ganglion neurons (SGNs), yet auditory outcomes remain highly variable.
Li Guo +6 more
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Metabolic-dysfunction-associated steatohepatitis impairs cochlear integrity and delays auditory recovery after noise trauma [PDF]
Cell Communication and SignalingBackground Chronic hearing impairment represents a major global health burden, profoundly diminishing quality of life due to its association with depression and cognitive decline.
Sheng Jin +8 more
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Severe Bilateral Sudden Sensorineural Hearing Loss Following Mild COVID‐19 Infection Requiring Cochlear Implantation: A Case Report [PDF]
Clinical Case ReportsSudden sensorineural hearing loss (SSNHL) has been reported following COVID‐19, but profound irreversible hearing loss after mild infection remains rare.
Tena Šimunjak +4 more
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Adriamycin nephropathy induces sensorineural hearing loss via blood–labyrinth barrier breakdown in BALB/c mice [PDF]
Scientific ReportsSensorineural hearing loss (SNHL) is significantly more prevalent in individuals with chronic kidney disease (CKD) than in the general population. Although a strong independent association has been observed between kidney dysfunction and the risk of ...
Akanksha Gajbhiye +10 more
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Cochlear Inflammatory Microenvironment in Age-Related Hearing Loss: Mechanisms and Recent Advances [PDF]
Clinical Interventions in AgingXiang Li,1,* Zhenhua Wu,1,* Qiang Zhou,2 Sen Lin1 1Department of Otolaryngology, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People’s Hospital), Wenzhou, 325200, People’s Republic of China; 2Department of ...
Li X, Wu Z, Zhou Q, Lin S
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Sentinels or saboteurs, the Janus face of cochlear-resident macrophages in hearing loss: spatiotemporal distribution, pathophysiological functions, and translational potential [PDF]
Journal of NeuroinflammationBackground Neuroinflammation is a critical mechanism underlying various forms of sensorineural hearing loss (SNHL). Contrary to the conventional view that cochlea is an immune-privileged organ shielded by the blood-labyrinth barrier, it is now evident ...
Hanrui Li +14 more
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Cochlear Implantation after Bilateral Transverse Temporal Bone Fractures [PDF]
Clinical and Experimental Otorhinolaryngology, 2008 Patients deafened by a severe head injury are rarely encountered. We report a case of a 65-yr-old man with bilateral transverse temporal bone fractures due to head injury. He underwent cochlear implant and achieved a satisfactory auditory rehabilitation.
Jong-Heon Shin +3 more
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