The Detrimental and Beneficial Functions of Macrophages After Cochlear Injury [PDF]
Frontiers in Cell and Developmental Biology, 2021 Macrophages are the main intrinsic immune cells in the cochlea; they can be activated and play a complicated role after cochlear injury. Many studies have shown that the number of macrophages and their morphological characteristics within the major ...
Yuan Zhang +12 more
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Use of Proteomic Imaging Coupled With Transcriptomic Analysis to Identify Biomolecules Responsive to Cochlear Injury [PDF]
Frontiers in Molecular Neuroscience, 2018 Exposure to noise or ototoxic agents can result in degeneration of cells in the sensory epithelium and auditory nerve, as well as non-sensory cells of the cochlear lateral wall.
Kenyaria V. Noble +7 more
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Cochlear neural functional competence: an integrative transcriptomic module analysis of excitability, plasticity and microenvironmental support programs [PDF]
Frontiers in Cellular NeuroscienceBackgroundCochlear implants (CIs) restore hearing by directly stimulating spiral ganglion neurons (SGNs), yet auditory outcomes remain highly variable.
Li Guo +6 more
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Severe Bilateral Sudden Sensorineural Hearing Loss Following Mild COVID‐19 Infection Requiring Cochlear Implantation: A Case Report [PDF]
Clinical Case ReportsSudden sensorineural hearing loss (SSNHL) has been reported following COVID‐19, but profound irreversible hearing loss after mild infection remains rare.
Tena Šimunjak +4 more
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Cochlear injury and adaptive plasticity of the auditory cortex [PDF]
Frontiers in Aging Neuroscience, 2015 Growing evidence suggests that cochlear stressors as noise exposure and aging can induce homeostatic/maladaptive changes in the central auditory system from the brainstem to the cortex.
ANNA R. eFETONI +3 more
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Rediscovering the Gut–Mito–Ear Axis: A Systems-Biology Framework for Ototoxic Vulnerability and Microbiome-Targeted Prevention [PDF]
CellsOtotoxicity is traditionally viewed as a local cochlear adverse effect of indispensable therapies such as cisplatin and aminoglycosides. However, emerging evidence suggests that cochlear vulnerability is shaped by systemic physiology, including ...
Chae Dong Yim +6 more
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Metabolic-dysfunction-associated steatohepatitis impairs cochlear integrity and delays auditory recovery after noise trauma [PDF]
Cell Communication and SignalingBackground Chronic hearing impairment represents a major global health burden, profoundly diminishing quality of life due to its association with depression and cognitive decline.
Sheng Jin +8 more
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Cochlear Implantation after Bilateral Transverse Temporal Bone Fractures [PDF]
Clinical and Experimental Otorhinolaryngology, 2008 Patients deafened by a severe head injury are rarely encountered. We report a case of a 65-yr-old man with bilateral transverse temporal bone fractures due to head injury. He underwent cochlear implant and achieved a satisfactory auditory rehabilitation.
Jong-Heon Shin +3 more
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Evaluation of hidden hearing loss in normal-hearing firearm users
Frontiers in Neuroscience, 2022 Some noise exposures resulting in temporary threshold shift (TTS) result in cochlear synaptopathy. The purpose of this retrospective study was to evaluate a human population that might be at risk for noise-induced cochlear synaptopathy (i.e., “hidden ...
Sarah K. Grinn, Colleen G. Le Prell
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Chronic suppurative otitis media causes macrophage-associated sensorineural hearing loss
Journal of Neuroinflammation, 2022 Background Chronic suppurative otitis media (CSOM) is the most common cause of permanent hearing loss in children in the developing world. A large component of the permanent hearing loss is sensory in nature and our understanding of the mechanism of this
Anping Xia +9 more
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