Results 41 to 50 of about 12,941 (217)
CellsThe cochlea is susceptible to damage from ototoxic agents such as cisplatin, yet the mechanisms underlying cochlear injury remain incompletely understood.
Bin Zeng +6 more
doaj +1 more source
c-Myb protects cochlear hair cells from cisplatin-induced damage via the PI3K/Akt signaling pathway
Cell Death Discovery, 2022 The transcription factor c-Myb is vital for cell survival, proliferation, differentiation, and apoptosis. We have previously reported that c-Myb knockdown exacerbates neomycin-induced damage to cochlea cells. However, the function and regulation of c-Myb
Chuan Bu +7 more
doaj +1 more source
Advanced Materials Technologies, EarlyView.Nanoporous silica nanoparticles incorporated in nanoporous platinum offer the possibility for implant‐associated drug delivery from neuronal electrodes. ABSTRACT Sensorineural hearing loss, resulting from damage to the hair cells of the inner ear, profoundly impairs quality of life.
Mosaieb Habib +10 more
wiley +1 more source
The role of diet in vulnerability to noise-induced cochlear injury and hearing loss [PDF]
The Journal of the Acoustical Society of America, 2019 The influence of dietary nutrient intake on the onset and trajectory of hearing loss during aging and in mediating protection from challenges such as noise is an important relationship yet to be fully appreciated. Dietary intake provides essential nutrients that support basic cellular processes related to influencing cellular stress response, immune ...
Christopher, Spankovich +1 more
openaire +2 more sources
Middle East Current Psychiatry, 2022 Background There is a greater incidence of mental health problems among children with hearing impairment compared to controls. A high proportion of children with hearing impairment experience delays in understanding, recognizing, and using emotional ...
A. Ghaly +4 more
doaj +1 more source
Advanced Materials Technologies, EarlyView.A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo +4 more
wiley +1 more source
Inhibition of TLR4 mitigates sensorineural hearing loss resulting from cochlear inflammation
Molecular MedicineBackground Inflammation is a principal cause of sensorineural hearing loss resulting from cochlear injury. However, current research investigating the mechanisms of sensorineural inflammatory injury remains inadequate.
Jintao Lou +11 more
doaj +1 more source
Ethical Precision in Nanoscale Brain Interfacing
Advanced Science, EarlyView.As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley +1 more source
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, EarlyView.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Blast-induced cochlear synaptopathy in chinchillas
Scientific Reports, 2018 When exposed to continuous high-level noise, cochlear neurons are more susceptible to damage than hair cells (HCs): exposures causing temporary threshold shifts (TTS) without permanent HC damage can destroy ribbon synapses, permanently silencing the ...
T. T. Hickman +4 more
doaj +1 more source