Results 11 to 20 of about 147 (76)

Rational Design of Inner Ear Drug Delivery Systems. [PDF]

Adv Sci (Weinh)
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Maimaitikelimu X, Xuan Z, Ren H, Chen K, Zhang H, Wang H.   +5 more
europepmc   +2 more sources

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism. [PDF]

Adv Sci (Weinh)
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Gagliardini M, Mechaussier S, Campos Pina C, Morais M, Postal O, Jean P, Dupont T, Singh-Estivalet A, Udugampolage S, Scandola C, Verpy E, Libé-Philippot B, Inbar TC, Schwenkgrub J, Spinola CMB, Etournay R, El-Amraoui A, Bathellier B, Mallet A, Delmaghani S, Giraudet F, Petit C, Gourévitch B, Avan P, Michalski N.   +24 more
europepmc   +2 more sources

A Modelling Study on the Comparison of Predicted Auditory Nerve Firing Rates for the Personalized Indication of Cochlear Implantation

Applied Sciences, 2022
The decision of whether to perform cochlear implantation is crucial because implantation cannot be reversed without harm. The aim of the study was to compare model-predicted time–place representations of auditory nerve (AN) firing rates for normal ...
Philipp Aichinger
doaj   +1 more source

The Effect of Lifetime Noise Exposure and Aging on Speech-Perception-in-Noise Ability and Self-Reported Hearing Symptoms: An Online Study

Frontiers in Aging Neuroscience, 2022
Animal research shows that aging and excessive noise exposure damage cochlear outer hair cells, inner hair cells, and the synapses connecting inner hair cells with the auditory nerve.
Adnan M. Shehabi, Adnan M. Shehabi, Garreth Prendergast, Hannah Guest, Christopher J. Plack, Christopher J. Plack   +5 more
doaj   +1 more source

Cochlear protection against noise exposure requires serotonin type 3A receptor via the medial olivocochlear system

The FASEB Journal, Volume 35, Issue 5, May 2021., 2021
Abstract The cochlear efferent feedback system plays important roles in auditory processing, including regulation of the dynamic range of hearing, and provides protection against acoustic trauma. These functions are performed through medial olivocochlear (MOC) neurons.
Kazuya Ohata, Makoto Kondo, Yoshiyuki Ozono, Yukiko Hanada, Takashi Sato, Hidenori Inohara, Shoichi Shimada   +6 more
wiley   +1 more source

Transient Abnormalities in Masking Tuning Curve in Early Progressive Hearing Loss Mouse Model

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Damage to cochlear outer hair cells (OHCs) usually affects frequency selectivity in proportion to hearing threshold increase. However, the current clinical heuristics that attributes poor hearing performance despite near‐normal auditory sensitivity to auditory neuropathy or “hidden” synaptopathy overlooks possible underlying OHC impairment.
Marion Souchal, Ludimila Labanca, Sirley Alves da Silva Carvalho, Luciana Macedo de Resende, Christelle Blavignac, Paul Avan, Fabrice Giraudet, Jeong-Han Lee   +7 more
wiley   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, Volume 12, Issue 29, August 7, 2025.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Complex auditory brainstem responses and speech-in-noise perception in young workers with occupational noise exposure

Frontiers in Audiology and Otology
The aim of this study was to investigate whether complex auditory brainstem response (c-ABR) outcomes and speech-in-noise perception performance are associated with occupational noise exposure in young noise-exposed workers with normal hearing thresholds
Lucile Lacomme, Wei Qiu, Adrian Fuente, Adrian Fuente   +3 more
doaj   +1 more source

Corrigendum: The effect of lifetime noise exposure and aging on speech-perception-in-noise ability and self-reported hearing symptoms: an online study

Frontiers in Aging Neuroscience, 2023
Adnan M. Shehabi, Adnan M. Shehabi, Garreth Prendergast, Hannah Guest, Christopher J. Plack, Christopher J. Plack   +5 more
doaj   +1 more source