Results 1 to 10 of about 1,850 (160)

Intermediate filaments link glutamate-aspartate transporter deficiency to cochlear synaptopathy. [PDF]

FEBS J
In a healthy ear, GLAST transporters in supporting cells clear excess glutamate to protect auditory connections. When GLAST is missing, glutamate accumulates and leads to the destruction of structural scaffolding within the postsynaptic nerve endings. This internal collapse causes a loss of synapses that are essential for hearing, ultimately resulting ...
Krumpoeck PE, Landegger LD.
europepmc   +2 more sources

Macrophages Promote Repair of Inner Hair Cell Ribbon Synapses following Noise-Induced Cochlear Synaptopathy. [PDF]

J Neurosci, 2023
Resident cochlear macrophages rapidly migrate into the inner hair cell synaptic region and directly contact the damaged synaptic connections after noise-induced synaptopathy.
Manickam V, Gawande DY, Stothert AR, Clayman AC, Batalkina L, Warchol ME, Ohlemiller KK, Kaur T.   +7 more
europepmc   +3 more sources

Preventive Effects of Ginkgo-Extract EGb 761^® on Noise Trauma-Induced Cochlear Synaptopathy. [PDF]

Nutrients, 2022
Noise trauma-induced loss of ribbon synapses at the inner hair cells (IHC) of the cochlea may lead to hearing loss (HL), resulting in tinnitus. We are convinced that a successful and sustainable therapy of tinnitus has to treat both symptom and cause ...
Tziridis K, Schulze H.
europepmc   +3 more sources

A Systematic Review: State of the Science on Diagnostics of Hidden Hearing Loss

Diagnostics
Background/Objectives: A sizeable population of patients with normal pure-tone audiograms endorse a consistent difficulty of following conversations in noisy environments.
Sunil Shenoy, Khushi Bhatt, Yalda Yazdani, Helia Rahimian, Hamid R. Djalilian, Mehdi Abouzari   +5 more
doaj   +1 more source

Looking for objective correlates between tinnitus and cochlear synaptopathy [PDF]

, 2020
Tinnitus is the perception of a sound in the absence of acoustic stimulation. While usually connected to a hearing loss, there exists a subset of tinnitus sufferers with audiologically normal hearing, whose tinnitus was often initiated by a noise trauma.
Casolani, Chiara, Harte, James Michael, Epp, Bastian; id_orcid 0000-0002-8062-0837   +2 more
openaire  

Cochlear synaptopathy and hidden hearing loss: a scoping review. [PDF]

Codas, 2023
Colla MF, Lunardelo PP, Dias FAM.
europepmc   +1 more source

Loss of Pex1 in Inner Ear Hair Cells Contributes to Cochlear Synaptopathy and Hearing Loss. [PDF]

Cells, 2022
Mauriac SA, Peineau T, Zuberi A, Lutz C, Géléoc GSG.   +4 more
europepmc   +1 more source

Metabotropic glutamate receptor: A new possible therapeutic target for cochlear synaptopathy. [PDF]

Iran J Basic Med Sci, 2022
Mahdi P, Pourbakht A, Karimi Yazdi A, Rabbani Anari M, Pirhajati Mahabadi V, Kamali M.   +5 more
europepmc   +1 more source

Auditory perception and neural representation of temporal features are altered by age but not by cochlear synaptopathy. [PDF]

Elife
Steenken F, Beutelmann R, Oetjen H, Köppl C, Klump GM.   +4 more
europepmc   +1 more source

DX243 counteracts both acoustic trauma-induced reduction in cortical brain oscillations and cochlear synaptopathy. [PDF]

Front Pharmacol
Fink S, Harasztosi C, Xie L, Silvente S, Attali P, Caron N, Singer W, Rüttiger L, Knipper M.   +8 more
europepmc   +1 more source