C-Phycocyanin Attenuates Noise-Induced Cochlear Synaptopathy via the Inhibition of Oxidative Stress and Intercellular Adhesion Molecule-1 in the Cochlea [PDF]
International Journal of Molecular SciencesThe synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are the most vulnerable structures in the noise-exposed cochlea.
Chih-Hung Wang +2 more
exaly +4 more sources
The search for noise-induced cochlear synaptopathy in humans: Mission impossible? [PDF]
Hearing Research, 2019 Animal studies demonstrate that noise exposure can permanently damage the synapses between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and there is no clinically relevant permanent threshold shift. Synaptopathy disrupts the afferent connection between the cochlea and the central auditory system and is predicted to ...
Bramhall, Naomi +8 more
openaire +10 more sources
Translational issues in cochlear synaptopathy
Hearing Research, 2017 Understanding the biology of the previously underappreciated sensitivity of cochlear synapses to noise insult, and its clinical consequences, is becoming a mission for a growing number of auditory researchers. In addition, several research groups have become interested in developing therapeutic approaches that can reverse synaptopathy and restore ...
, Michael Heinz, Ann E Hickox
exaly +3 more sources
Auditory synaptopathy, auditory neuropathy, and cochlear implantation [PDF]
Laryngoscope Investigative Otolaryngology, 2019 Cochlear implantation has become the standard‐of‐care for adults and children with severe to profound hearing loss. There is growing evidence that qualitative as well as quantitative deficits in the auditory nerve may affect cochlear implant (CI ...
Aiden Eliot Shearer, Marlan R. Hansen
doaj +3 more sources
Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma [PDF]
Scientific ReportsEndolymphatic hydrops, increased endolymphatic fluid within the cochlea, is the key pathologic finding in patients with Meniere’s disease, a disease of episodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness.
Michelle L. Fong +11 more
doaj +2 more sources
Auditory Brainstem Response Latency in Noise as a Marker of Cochlear Synaptopathy [PDF]
The Journal of Neuroscience, 2016 Evidence from animal and human studies suggests that moderate acoustic exposure, causing only transient threshold elevation, can nonetheless cause “hidden hearing loss” that interferes with coding of suprathreshold sound. Such noise exposure destroys synaptic connections between cochlear hair cells and auditory nerve fibers; however, there is no ...
Golbarg Mehraei +6 more
openaire +6 more sources
Role of cochlear synaptopathy in cytomegalovirus infected mice and in children [PDF]
International Journal of Pediatric Otorhinolaryngology, 2020 Determine whether a murine model of cytomegalovirus (CMV) and CMV- infected children show evidence of synaptopathy.Murine model of CMV infection and case series.C57 BL/6 mice were inoculated with murine-CMV (mCMV). Auditory function was assessed using Auditory Brainstem Response (ABR) and distortion product otoacoustic emission (DPOAE) testing ...
Ali Almishaal +12 more
openaire +4 more sources
The outcome of cochlear implantation in otoferlin-related cochlear synaptopathy [PDF]
, 2023 Objectives Auditory neuropathy is a hearing disorder characterized by disruption of the temporal coding of acoustic signals in the auditory fibers, which results from alterations at pre- and post-synaptic sites. The most well- known pre-synaptic form of AN is associated with mutations in the OTOF gene encoding otoferlin, a transmembrane protein ...
Rosamaria Santarelli +7 more
openaire +2 more sources
Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss [PDF]
Neural Plasticity, 2016 Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs ...
Lijuan Shi +5 more
doaj +4 more sources
Age-Dependent Auditory Processing Deficits after Cochlear Synaptopathy Depend on Auditory Nerve Latency and the Ability of the Brain to Recruit LTP/BDNF [PDF]
Brain Sciences, 2020 Age-related decoupling of auditory nerve fibers from hair cells (cochlear synaptopathy) has been linked to temporal processing deficits and impaired speech recognition performance. The link between both is elusive.
Philine Marchetta +9 more
doaj +3 more sources