Non-Invasive Assays of Cochlear Synaptopathy – Candidates and Considerations [PDF]
Neuroscience, 2019 Abstract Studies in multiple species, including in post-mortem human tissue, have shown that normal aging and/or acoustic overexposure can lead to a significant loss of afferent synapses innervating the cochlea. Hypothetically, this cochlear synaptopathy can lead to perceptual deficits in challenging environments and can contribute to ...
Hari Bharadwaj +2 more
exaly +5 more sources
Reliability and interrelations of seven proxy measures of cochlear synaptopathy [PDF]
Hearing Research, 2019 Investigations of cochlear synaptopathy in living humans rely on proxy measures of auditory nerve function. Numerous procedures have been developed, typically based on the auditory brainstem response (ABR), envelope-following response (EFR), or middle-ear-muscle reflex (MEMR).
Kevin J Munro +2 more
exaly +7 more sources
Stress Affects Central Compensation of Neural Responses to Cochlear Synaptopathy in a cGMP-Dependent Way [PDF]
Frontiers in Neuroscience, 2022 In light of the increasing evidence supporting a link between hearing loss and dementia, it is critical to gain a better understanding of the nature of this relationship.
Daria Savitska +10 more
doaj +5 more sources
Loud Music Exposure and Cochlear Synaptopathy in Young Adults: Isolated Auditory Brainstem Response Effects but No Perceptual Consequences [PDF]
Trends in Hearing, 2017 The purpose of this study was to test the hypothesis that listeners with frequent exposure to loud music exhibit deficits in suprathreshold auditory performance consistent with cochlear synaptopathy. Young adults with normal audiograms were recruited who
Emily Buss, John Grose
exaly +4 more sources
Local delivery of soluble fractalkine (CX3CL1) peptide restores ribbon synapses after noise-induced cochlear synaptopathy [PDF]
Frontiers in Cellular NeuroscienceCochlear ribbon synapses between sensory inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are vulnerable to rapid and primary damage and/or loss due to noise overexposure.
Vijayprakash Manickam +10 more
doaj +5 more sources
Envelope following response measurements in young veterans are consistent with noise-induced cochlear synaptopathy [PDF]
Hearing Research, 2021 Animal studies have demonstrated that noise exposure can lead to the loss of the synapses between the inner hair cells and their afferent auditory nerve fiber targets without impacting auditory thresholds.
Naomi Bramhall +2 more
exaly +4 more sources
Blast-induced cochlear synaptopathy in chinchillas [PDF]
Scientific Reports, 2018 When exposed to continuous high-level noise, cochlear neurons are more susceptible to damage than hair cells (HCs): exposures causing temporary threshold shifts (TTS) without permanent HC damage can destroy ribbon synapses, permanently silencing the ...
T. T. Hickman +4 more
doaj +3 more sources
The Relative Contribution of Cochlear Synaptopathy and Reduced Inhibition to Age-Related Hearing Impairment for People With Normal Audiograms [PDF]
Trends in Hearing, 2023 Older people often show auditory temporal processing deficits and speech-in-noise intelligibility difficulties even when their audiogram is clinically normal. The causes of such problems remain unclear.
Marcelo Gómez-Álvarez +4 more
doaj +2 more sources
Y-27632, a ROCK inhibitor, improved laser-induced shock wave (LISW)-induced cochlear synaptopathy in mice [PDF]
Molecular Brain, 2021 Recently, a pathological condition called cochlear synaptopathy has been clarified, and as a disorder of the auditory nerve synapses that occurs prior to failure of hair cells, it has been recognized as a major cause of sensorineural hearing loss ...
Yutaka Koizumi +5 more
doaj +2 more sources
Use of the auditory brainstem response for assessment of cochlear synaptopathy in humans [PDF]
The Journal of the Acoustical Society of America, 2021 Although clinical use of the auditory brainstem response (ABR) to detect retrocochlear disorders has been largely replaced by imaging in recent years, the discovery of cochlear synaptopathy has thrown this foundational measure of auditory function back into the spotlight.
Bramhall NF.
openaire +3 more sources