Effects of Age and Noise Exposure on Proxy Measures of Cochlear Synaptopathy [PDF]
Trends in Hearing, 2019 Although there is strong histological evidence for age-related synaptopathy in humans, evidence for the existence of noise-induced cochlear synaptopathy in humans is inconclusive.
Kevin J Munro +2 more
exaly +8 more sources
Categorization of tinnitus listeners with a focus on cochlear synaptopathy. [PDF]
PLoS ONE, 2022 Tinnitus is a complex and not yet fully understood phenomenon. Often the treatments provided are effective only for subgroups of sufferers. We are presently not able to predict benefit with the currently available diagnostic tools and analysis methods ...
Chiara Casolani +2 more
doaj +9 more sources
Unraveling the molecular landscape of lead-induced cochlear synaptopathy: a quantitative proteomics analysis [PDF]
Frontiers in Cellular NeuroscienceIntroductionExposure to heavy metal lead can cause serious health effects such as developmental neurotoxicity in infants, cognitive impairment in children, and cardiovascular and nephrotoxic effects in adults.
Samson Jamesdaniel, Paul Stemmer
exaly +7 more sources
Assessment of cochlear synaptopathy by electrocochleography to low frequencies in a preclinical model and human subjects [PDF]
Frontiers in Neurology, 2023 Cochlear synaptopathy is the loss of synapses between the inner hair cells and the auditory nerve despite survival of sensory hair cells. The findings of extensive cochlear synaptopathy in animals after moderate noise exposures challenged the long-held ...
Raymond A. Haggerty +9 more
doaj +8 more sources
Cochlear synaptopathy impairs suprathreshold tone‐in‐noise coding in the cochlear nucleus [PDF]
The Journal of Physiology, 2023 AbstractHearing impairment without threshold elevations can occur when there is damage to high‐threshold auditory nerve fibre synapses with cochlear inner hair cells. Instead, cochlear synaptopathy produces suprathreshold deficits, especially in older patients, which affect conversational speech.
A. Hockley +4 more
europepmc +6 more sources
Ultrastructure of noise-induced cochlear synaptopathy [PDF]
Scientific Reports, 2023 Acoustic overexposure can eliminate synapses between inner hair cells (IHCs) and auditory nerve fibers (ANFs), even if hair-cell function recovers. This synaptopathy has been extensively studied by confocal microscopy, however, understanding the nature ...
Daniel J. Moverman +4 more
doaj +4 more sources
Detecting Cochlear Synaptopathy Through Curvature Quantification of the Auditory Brainstem Response [PDF]
Frontiers in Cellular Neuroscience, 2022 The sound-evoked electrical compound potential known as auditory brainstem response (ABR) represents the firing of a heterogenous population of auditory neurons in response to sound stimuli, and is often used for clinical diagnosis based on wave ...
Jianxin Bao +9 more
doaj +4 more sources
Cochlear synaptopathy: new findings in animal and human research [PDF]
Reviews in the Neurosciences, 2020 Abstract In animal models, prolonged exposure (2 h) to high-level noise causes an irreparable damage to the synapses between the inner hair cells and auditory nerve fibers within the cochlea. Nevertheless, this injury does not necessarily alter the hearing threshold. Similar findings have been observed as part of typical aging in animals.
Cristian Aedo Sanchez
exaly +6 more sources
Effects of age on electrophysiological measures of cochlear synaptopathy in humans [PDF]
Hearing Research, 2020 Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. Because CS affects mainly low-spontaneous rate auditory nerve fibers, differential electrophysiological measures such as the ratio of the amplitude of wave I ...
Samuele Carcagno +1 more
exaly +7 more sources
Tinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy [PDF]
Hearing Research, 2017 In rodents, exposure to high-level noise can destroy synapses between inner hair cells and auditory nerve fibers, without causing hair cell loss or permanent threshold elevation. Such "cochlear synaptopathy" is associated with amplitude reductions in wave I of the auditory brainstem response (ABR) at moderate-to-high sound levels.
Kevin J Munro +2 more
exaly +7 more sources