Cochlear Synaptopathy Causes Loudness Perception Impairment without Hearing Loss
Noise and Health, 2022 Purpose: In this study, the development of a quantitative measurement method to predict long-term auditory adaptation through the stimuli that have been modulated according to different short-term modulation types was aimed to form a psychoacoustic test battery.
TÜRKYILMAZ, MERAL DİDEM +2 more
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Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis [PDF]
Frontiers in Neuroscience, 2021 Noise-induced cochlear synaptopathy (CS) is defined as a permanent loss of synapses in the auditory nerve pathway following noise exposure. Several studies using auditory brainstem response (ABR) have indicated the presence of CS and increased central ...
Feifan Chen +4 more
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Protocol for assessing auditory function, cochlear synaptopathy, and afferent terminal morphology in laboratory mice [PDF]
STAR ProtocolsSummary: Here, we present a protocol for evaluating auditory function and synaptic molecular-structural integrity in mice, specifically female GluA3-knockout (GluA3KO) mice raised in quiet or ambient sound levels. We describe steps for combining auditory
Indra Pal +6 more
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Auditory-nerve responses in mice with noise-induced cochlear synaptopathy
Journal of Neurophysiology, 2021 Noise-induced damage to synapses between inner hair cells and auditory-nerve fibers (ANFs) can occur without permanent hair cell damage, resulting in pathophysiology that “hides” behind normal thresholds. Prior single-fiber neurophysiology in guinea pig suggested that noise selectively targets high-threshold ANFs.
Kirupa Suthakar, M. Charles Liberman
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Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms
Hearing Research, 2017 Common causes of hearing loss in humans - exposure to loud noise or ototoxic drugs and aging - often damage sensory hair cells, reflected as elevated thresholds on the clinical audiogram. Recent studies in animal models suggest, however, that well before this overt hearing loss can be seen, a more insidious, but likely more common, process is taking ...
M Charles Liberman, Sharon G Kujawa
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Effectiveness of auditory measures in the diagnosis of cochlear synaptopathy and noise-induced hidden hearing loss: a case–control study [PDF]
The Egyptian Journal of OtolaryngologyBackground Cochlear synaptopathy is a disorder where auditory perceptual impairments, such as speech perception in noise and tinnitus, may not be accurately reflected by audiometric thresholds, even if the audiogram appears normal.
Soha Mekki +4 more
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I' Wave Auditory Brainstem Response as a Possible Indicator of Noise-Induced Cochlear Synaptopathy. [PDF]
Iran J Child NeurolObjectives: Cochlear synaptopathy, caused by the destruction of synaptic connections due to aging, noise exposure, and ototoxic agents, is defined as auditory dysfunction despite the normal hearing threshold, specifically in challenging situations.
Borna A +4 more
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Possible Existence of Cochlear Synaptopathy in Patients Completely Recovered from Idiopathic Sudden Sensorineural Hearing Loss. [PDF]
J Clin Med, 2022 Cochlear synaptopathy refers to a subclinical hearing pathology which could potentially explain hearing difficulties within the normal hearing threshold; it is also called “hidden hearing loss”.
Seo HW +4 more
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Audiology Research, 2023 Cochlear synaptic loss (termed cochlear synaptopathy) has been suggested to contribute to suprathreshold hearing difficulties. However, its existence and putative effects in humans remain inconclusive, largely due to the heterogeneous methods used across
Kailyn A. McFarlane, Jason Tait Sanchez
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Assumption behind the connection between tinnitus, cochlear synaptopathy and high-frequency hearing loss. [PDF]
, 2022 The assumption is that a noise trauma triggers a temporal threshold shift, accompanied by cochlear synaptopathy. With time, the thereby reduced input into the brain stem leads to tinnitus and to spiral ganglion neuron (SGN) degeneration.
James Michael Harte (14253362) +2 more
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