Results 61 to 70 of about 1,850 (160)

Differences in Calcium Clearance at Inner Hair Cell Active Zones May Underlie the Difference in Susceptibility to Noise-Induced Cochlea Synaptopathy of C57BL/6J and CBA/CaJ Mice

Frontiers in Cell and Developmental Biology, 2021
Noise exposure of a short period at a moderate level can produce permanent cochlear synaptopathy without seeing lasting changes in audiometric threshold.
Hongchao Liu, Hongchao Liu, Hongchao Liu, Hu Peng, Longhao Wang, Longhao Wang, Longhao Wang, Pengcheng Xu, Pengcheng Xu, Pengcheng Xu, Zhaoyan Wang, Zhaoyan Wang, Zhaoyan Wang, Huihui Liu, Huihui Liu, Huihui Liu, Hao Wu, Hao Wu, Hao Wu   +18 more
doaj   +1 more source

Diagnostic Approaches for Hidden Hearing Loss and Cochlear Synaptopathy: A Systematic Review [PDF]

, 2020
Cochlear synaptopathy, also known as “hidden hearing loss,” is a recently described auditory disorder that is believed to affect auditory neural processing (Kohrman et al., 2020).
Sprouse, Ryan, Fischer, Alyssa
core   +2 more sources

Relative changes in the cochlear summating potentials to paired-clicks predict speech-in-noise perception and subjective hearing acuity [PDF]

JASA Express Letters, 2022
Objective assays of human cochlear synaptopathy (CS) have been challenging to develop. It is suspected that relative summating potential (SP) changes are different in listeners with CS.
Jesyin Lai, Gavin M. Bidelman
doaj   +1 more source

No effect of occupational noise exposure on auditory brainstem response and speech perception in noise

Frontiers in Neuroscience, 2022
The primary aim of this study was to investigate whether auditory brainstem response (ABR) and speech perception in noise (SPiN) were associated with occupational noise exposure in normal hearing young factory workers.
Alexis Pinsonnault-Skvarenina, Alexis Pinsonnault-Skvarenina, Alexis Pinsonnault-Skvarenina, Karina Moïn-Darbari, Karina Moïn-Darbari, Wulan Zhao, Meibian Zhang, Wei Qiu, Adrian Fuente, Adrian Fuente   +9 more
doaj   +1 more source

Lead exposure induces nitrative stress and disrupts ribbon synapses in the cochlea

Frontiers in Molecular Neuroscience, 2022
Environmental exposure to heavy metal lead, a public health hazard in many post-industrial cities, causes hearing impairment upon long-term exposure. Lead-induced cochlear and vestibular dysfunction is well-documented in animal models.
Rita Rosati, Johnna A. Birbeck, Judy Westrick, Samson Jamesdaniel, Samson Jamesdaniel   +4 more
doaj   +1 more source

Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate

Frontiers in Molecular Neuroscience, 2020
Sensorineural hearing loss (SNHL) caused by noise exposure and attendant loss of glutamatergic synapses between cochlear spiral ganglion neurons (SGNs) and hair cells is the most common sensory deficit worldwide. We show here that systemic administration
Richard Seist, Richard Seist, Richard Seist, Mingjie Tong, Mingjie Tong, Lukas D. Landegger, Lukas D. Landegger, Lukas D. Landegger, Sasa Vasilijic, Sasa Vasilijic, Hiroshi Hyakusoku, Hiroshi Hyakusoku, Hiroshi Hyakusoku, Sachiyo Katsumi, Sachiyo Katsumi, Charles E. McKenna, Albert S. B. Edge, Albert S. B. Edge, Albert S. B. Edge, Albert S. B. Edge, Konstantina M. Stankovic, Konstantina M. Stankovic, Konstantina M. Stankovic, Konstantina M. Stankovic, Konstantina M. Stankovic   +24 more
doaj   +1 more source

Dose-Dependent Pattern of Cochlear Synaptic Degeneration in C57BL/6J Mice Induced by Repeated Noise Exposure

Neural Plasticity, 2021
It is widely accepted that even a single acute noise exposure at moderate intensity that induces temporary threshold shift (TTS) can result in permanent loss of ribbon synapses between inner hair cells and afferents.
Minfei Qian, Qixuan Wang, Zhongying Wang, Qingping Ma, Xueling Wang, Kun Han, Hao Wu, Zhiwu Huang   +7 more
doaj   +1 more source

Genome-wide Association Study for Noise-induced Cochlear Synaptopathy [PDF]

, 2018
Article SummaryIn order to elucidate the genetic architecture of the auditory hair cell synapse and the susceptibility to noise-induced cochlear synaptopathy, we are providing the first genome-wide association study with 111 strains (n=695) of the Hybrid

core   +1 more source

Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

Frontiers in Cell and Developmental Biology, 2021
After acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis.
Ido Badash, Patricia M. Quiñones, Kevin J. Oghalai, Juemei Wang, Christopher G. Lui, Frank Macias-Escriva, Brian E. Applegate, Brian E. Applegate, John S. Oghalai, John S. Oghalai   +9 more
doaj   +1 more source

Osmotic stabilization prevents cochlear synaptopathy after blast trauma [PDF]

Proceedings of the National Academy of Sciences, 2018
SignificanceTrauma due to roadside bombs is an unfortunate consequence of modern warfare and terrorist attacks. Hearing loss often occurs because the cochlea is the body’s most sensitive pressure transducer. Here, we used in vivo imaging of the mouse cochlea using optical coherence tomography to show that increased endolymph volume correlates with ...
Jinkyung, Kim, Anping, Xia, Nicolas, Grillet, Brian E, Applegate, John S, Oghalai   +4 more
openaire   +2 more sources