Results 81 to 90 of about 1,850 (160)

Noise-induced Cochlear Synaptopathy with and Without Sensory Cell Loss

Neuroscience, 2020
Prior work has provided extensive documentation of threshold sensitivity and sensory hair cell losses after noise exposure. It is now clear, however, that cochlear synaptic loss precedes such losses, at least at low-moderate noise doses, silencing affected neurons.
Katharine A. Fernandez, Dan Guo, Steven Micucci, Victor De Gruttola, M. Charles Liberman, Sharon G. Kujawa   +5 more
openaire   +3 more sources

Noise-induced cochlear synaptopathy in rhesus monkeys ( Macaca mulatta ) [PDF]

Hearing Research, 2017
Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in mice can destroy up to ∼50% of synapses between auditory nerve fibers (ANFs) and inner hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the ...
M D, Valero, J A, Burton, S N, Hauser, T A, Hackett, R, Ramachandran, M C, Liberman   +5 more
openaire   +2 more sources

Image_1_Stress Affects Central Compensation of Neural Responses to Cochlear Synaptopathy in a cGMP-Dependent Way.TIF [PDF]

, 2022
In light of the increasing evidence supporting a link between hearing loss and dementia, it is critical to gain a better understanding of the nature of this relationship.
Lukas Rüttiger (224219), Marlies Knipper (224235), Daria Savitska (10454597), Philine Marchetta (8692149), Csaba Harasztosi (5572526), Philipp Eckert (5572514), Morgan Hess (13172841), Stefan Fink (9747371), Wibke Singer (306957), Peter Ruth (219252), Dila Calis (13172844)   +10 more
core   +1 more source

Table_1_Stress Affects Central Compensation of Neural Responses to Cochlear Synaptopathy in a cGMP-Dependent Way.docx [PDF]

, 2022
In light of the increasing evidence supporting a link between hearing loss and dementia, it is critical to gain a better understanding of the nature of this relationship.
Lukas Rüttiger (224219), Marlies Knipper (224235), Daria Savitska (10454597), Philine Marchetta (8692149), Csaba Harasztosi (5572526), Philipp Eckert (5572514), Morgan Hess (13172841), Stefan Fink (9747371), Wibke Singer (306957), Peter Ruth (219252), Dila Calis (13172844)   +10 more
core   +1 more source

Can rollover be used to assess cochlear synaptopathy in listeners with normal audiograms? [PDF]

While a level increase typically leads to better speech intelligibility (SI) at low presentation levels, it can result in decreased SI at high levels. SI declines with increasing level, so-called rollover (RO), have been observed in quiet and in noise ...
Van Yper, Lindsey Nadine, Fereczkowski, Michal, Neher, Tobias; id_orcid   +2 more
core   +6 more sources

An Experimental Study on the Protective Effect of Memantine in Noise‐Induced Hearing Loss

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective This study examined the potential protective effects of memantine, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist, against acoustic trauma (AT) in guinea pigs, using electrophysiological and histopathological analyses. Methods Thirty guinea pigs with normal hearing were divided into six groups (n = 5 per group): Group 1 (control),
Begüm Arda, Selis Gülseven Güven, Erdoğan Bulut, Murat Arslan, Özlem Tuğce Çilingir‐Kaya, Abdullah Taş, Recep Yağız   +6 more
wiley   +1 more source

Noise‐induced reduction and early recovery of superior paraolivary nucleus sound‐offset responses

The Journal of Physiology, EarlyView.
Abstract figure legend Acoustic over‐exposure transiently disrupts auditory temporal processing in mouse superior paraolivary nucleus neurons. In control conditions, neurons exhibit robust sound‐offset (OFF) responses, which are abolished immediately following noise trauma, indicating impaired temporal encoding.
Mihai Stancu, Ezhilarasan Rajaram, Joseph A. Kroeger, Benedikt Grothe, Conny Kopp‐Scheinpflug   +4 more
wiley   +1 more source

Central Compensation of Cochlear Synaptopathy is not Dependent on Age, but on LTP/BDNF Recruitment [PDF]

, 2022
Trabajo presentado en el 44th Annual MidWinter Meeting, celebrado en modalidad virtual del 20 al 24 de febrero de 2022.[Background]: Age-related loss of synaptic contacts between inner hair cells and auditory-nerve fibers (cochlear synaptopathy) has been
Savitska, Daria, Rüttiger, Lukas, Asola, Giulia, Möhrle, Dorit, Schimmang, Thomas, Manthey, Marie, Kübler, Angelika, Marchetta, Philine, Singer, Wibke, Knipper, Marlies   +9 more
core  

A Modelling Study on the Comparison of Predicted Auditory Nerve Firing Rates for the Personalized Indication of Cochlear Implantation

Applied Sciences, 2022
The decision of whether to perform cochlear implantation is crucial because implantation cannot be reversed without harm. The aim of the study was to compare model-predicted time–place representations of auditory nerve (AN) firing rates for normal ...
Philipp Aichinger
doaj   +1 more source

Comparative Cochlear–Vestibular Aging Reveals Age‐Aligned Mitochondrial Ultrastructural Burden, Mitophagy–Autophagy Remodeling, Synaptic Uncoupling, and Sensory Functional Decline

Aging Cell, Volume 25, Issue 7, July 2026.
This study maps age‐aligned cochlear and vestibular decline in SAMP8 mice, linking functional impairment with synaptic vulnerability, mitochondrial ultrastructural injury, and autophagy/mitophagy–lysosome transcriptional remodeling. The findings provide an integrated framework for understanding shared inner‐ear aging trajectories.
Jingyi Xie, Xujia Zhang, Jinyi Tian, Yulu Yan, Ke Shi, Yongqi Pan, Yanni Zhang, Zichen Chen, Jianbin Sun, Hui Lv, Jingguo Chen, Xiaoyong Ren, Teru Kamogashira, Xiaotong Zhang, Ying Gao   +14 more
wiley   +1 more source