Results 101 to 110 of about 1,850 (160)
OTO Open, Volume 10, Issue 2, April-June 2026.Abstract Objective The pathophysiology of noise‐induced hearing loss (NIHL) encompasses excessive inflammation, tissue damage, production of reactive oxygen species, and apoptotic processes, culminating in irreversible damage to hair cells. Currently, no clinical interventions are available to mitigate this condition.
Benyamin M. Kaminer +6 more
wiley +1 more source
Auditory Neuropathy: Challenges and Significant Progress in Diagnosis and Treatment
Advanced Therapeutics, Volume 9, Issue 3, March 2026.Auditory neuropathy is a complex disorder that causes sensorineural hearing impairment in patients. Recently, breakthrough progress has been made in the gene therapy of auditory neuropathy. This review focuses on auditory neuropathy, covering its pathophysiology, etiology, epidemiology, clinical manifestations, diagnostic techniques, treatment ...
Wen Xie +11 more
wiley +1 more source
Trk agonist drugs rescue noise-induced hidden hearing loss
JCI Insight, 2021 TrkB agonist drugs are shown here to have a significant effect on the regeneration of afferent cochlear synapses after noise-induced synaptopathy. The effects were consistent with regeneration of cochlear synapses that we observed in vitro after synaptic
Katharine A. Fernandez +6 more
doaj +1 more source
Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects.
PLoS Computational Biology, 2021 Hidden hearing loss (HHL) is an auditory neuropathy characterized by normal hearing thresholds but reduced amplitudes of the sound-evoked auditory nerve compound action potential (CAP).
Maral Budak +5 more
doaj +1 more source
Noise-induced cochlear synaptopathy: Past findings and future studies
Hearing Research, 2017 For decades, we have presumed the death of hair cells and spiral ganglion neurons are the main cause of hearing loss and difficulties understanding speech in noise, but new findings suggest synapse loss may be the key contributor. Specifically, recent preclinical studies suggest that the synapses between inner hair cells and spiral ganglion neurons ...
Megan Kobel +4 more
openaire +2 more sources
Hearing Loss: From Basic to Clinical Science
Advanced Science, Volume 13, Issue 7, 3 February 2026.Abstract Hearing loss (HL) affects over 1.5 billion people globally, with genetic factors accounting for ≈50% of congenital cases. Therefore, HL has become a global health issue, driving extensive research from basic science to clinical applications. This Special Collection includes a total of 31 papers, among which 9 are review papers, 21 are research
Renjie Chai, Hai Huang, Jing Zou
wiley +1 more source
Chinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 1-24, February 2026.ABSTRACT Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.
Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy; Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery +43 more
wiley +1 more source
Cochlear synaptopathy and hidden hearing loss: a scoping review
CoDASABSTRACT Purpose To identify the pathophysiological definitions adopted by studies investigating “cochlear synaptopathy” (CS) and “hidden hearing loss” (HHL). Research strategies The combination of keywords “Auditory Synaptopathy” or “Neuronal Synaptopathy” or “Hidden Hearing Loss” with “etiology” or “causality” or “diagnosis” was used in the ...
Marina de Figueiredo Colla +2 more
openaire +2 more sources
The Current Situation and Development of Endoscopic Ear Surgery in China
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 136-143, February 2026.ABSTRACT Endoscopic ear surgery has been widely performed in China since 2015 due to the development and rapid popularization of endoscopic technology. Due to the relative shortness of the auditory meatus, only a fixed endoscope is required in many cases, rather than a motion similar to a nasal endoscope, and uncontrollable bleeding is virtually non ...
Meng‐Wen Shi, Ge Yin, Yu Sun
wiley +1 more source
Electrocochleographic Changes Predict an Early Sign of Cochlear Degeneration
World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 1, Page 89-100, February 2026.ABSTRACT Objectives The purpose of this study is to identify the earliest appearing auditory electrophysiological indicators that change with age progression in young adults with normal hearing, and to analyze the frequency distribution patterns of these markers in the cochlear.
Min‐Fei Qian +6 more
wiley +1 more source