Results 111 to 120 of about 1,850 (160)
Brain and Behavior, Volume 16, Issue 1, January 2026.We quantitatively analyzed the cerebral white matter microstructure in patients with CMT using DTI. We identified cerebral white matter microstructural abnormalities in CMT patients, including the FMA and ILF. These alterations correlated with ABR interpeak latencies, suggesting impaired central auditory processing due to disrupted axonal‐myelin ...
Peng Wang +9 more
wiley +1 more source
Aging Cell, Volume 25, Issue 1, January 2026.Chronic low‐concentration lead exposure accelerates the development of ARHL. Lead exposure mediates damage to cochlear sensory cells via the mitochondrial protease LONP1, leading to irreversible hearing loss. ABSTRACT Heavy metal ion exposure has become a global public health concern.
Xue Bai +10 more
wiley +1 more source
Molecular Therapy: Methods & Clinical Development, 2016 Synaptopathy in the cochlea occurs when the connection between inner hair cells and the auditory nerve is disrupted, leading to impaired hearing and nerve degeneration. Experiments using transgenic mice have shown that overexpression of NT3 by supporting
Min Young Lee +7 more
doaj +1 more source
BioMed Research International, Volume 2026, Issue 1, 2026.Chronic noise is a major environmental risk factor leading to a number of pathologies in different parts of organisms, with a profound impact on health. The auditory system is the most vulnerable to the damaging effects of noise. However, sound processing is also supported by brain regions outside the classical auditory pathways, including limbic areas.
Nino Pochkhidze +9 more
wiley +1 more source
Characteristics of Hearing Loss in Type 2 Diabetes Mellitus: A Systematic Review and Meta‐Analysis
Otolaryngology–Head and Neck Surgery, Volume 173, Issue 6, Page 1317-1327, December 2025.Abstract Methods A systematic review of CINAHL, Cochrane Library, PubMed, and SCOPUS databases was conducted according to PRISMA guidelines to identify studies evaluating T2DM and hearing loss. Primary outcome measures included continuous measures (mean), proportions (%), proportional difference (∆), and relative risks (RR) with 95% confidence ...
Cory Hyun‐su Kim +6 more
wiley +1 more source
OTOF Gene Therapy: From Breakthroughs to Roadmaps
MedComm, Volume 7, Issue 3, March 2026.
Qiuju Wang +2 more
wiley +1 more source
Beyond conventional audiograms : thresholds in quiet and noise and their diagnostic potential for noise-induced cochlear synaptopathy [PDF]
, 2021 Purpose: Studies in rodents, and more recently humans, suggest that noise exposure can cause permanent damage to synaptic ribbons between cochlear inner hair cells and auditory nerve synapses.
Ma, Ainsley
core
Spatial patterns of noise-induced inner hair cell ribbon loss in the mouse mid-cochlea
iScienceSummary: In the mammalian cochlea, moderate acoustic overexposure leads to loss of ribbon-type synapse between the inner hair cell (IHC) and its postsynaptic spiral ganglion neuron (SGN), causing a reduced dynamic range of hearing but not a permanent ...
Yan Lu +8 more
doaj +1 more source
Reliability and interrelations of seven proxy measures of cochlear synaptopathy
The Journal of the Acoustical Society of America, 2018 Investigations of cochlear synaptopathy in living humans rely on proxy measures of auditory nerve function. Numerous procedures have been developed, typically based on the auditory brainstem response (ABR), envelope-following response (EFR), or middle-ear muscle reflex (MEMR).
Christopher J. Plack +2 more
openaire +2 more sources
Evidence for age-related cochlear synaptopathy in humans unconnected to speech-in-noise intelligibility deficits [PDF]
, 2019 [EN] Cochlear synaptopathy (or the loss of primary auditory synapses) remains a subclinical condition of uncertain prevalence. Here, we investigate whether it affects humans and whether it contributes to suprathreshold speech-in-noise intelligibility ...
Johannesen, Peter Tinggaard +2 more
core +1 more source