Results 91 to 100 of about 1,850 (160)

Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related inner hair cell synaptopathy and slows age-related hearing loss [PDF]

, 2022
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive pathology often has psychological and medical comorbidities, including social isolation, depression, and cognitive decline.
M. Charles Liberman, Corfas, Gabriel, Beatriz C. Borges, Gabriel Corfas, Nathan D. Cass, Desai, Aditi S., Kohrman, David C., Lingchao Ji, Luis R. Cassinotti, Aditi S. Desai, Cassinotti, Luis R., Liberman, M. Charles, David C. Kohrman, Borges, Beatriz C., Ji, Lingchao, Cass, Nathan D.   +15 more
core   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, Volume 2, Issue 2, June 2026.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

AMPKα Silencing Prevents Kanamycin‐Induced Ototoxicity in an Acute Mouse Model

Sensory Neuroscience, Volume 2, Issue 2, June 2026.
Kanamycin plus furosemide (KM + FU) treatment (acute ototoxic model) causes AMPKα activation and rapidly induces cochlear outer hair cell (OHC) loss. Silencing AMPKα1 via posterior semicircular canal injection 48 h before KM + FU treatment reduces this damage, preserving OHCs and hearing.
Shengyu Zou, Fan Wu, Qiaojun Fang, Zuhong He, Hongguo Su, Shan Xu, Su‐Hua Sha   +6 more
wiley   +1 more source

Perceptual Consequences of Cochlear Deafferentation in Humans

Trends in Hearing
Cochlear synaptopathy, a form of cochlear deafferentation, has been demonstrated in a number of animal species, including non-human primates. Both age and noise exposure contribute to synaptopathy in animal models, indicating that it may be a common type
Naomi F. Bramhall, Garnett P. McMillan
doaj   +1 more source

Luteolin Protects Against Noise‐Induced Hearing Loss via Mitigating Oxidative Stress and Apoptosis, With Potential Regulation of the EGR1/SPRY4 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Luteolin attenuates noise‐induced auditory hair cell loss, as well as TBHP‐induced oxidative stress and apoptosis. EGR1 modulates the transcription of SPRY4; the expression levels of both factors are upregulated following TBHP exposure, and this inductive effect is abrogated by luteolin treatment.
Jia‐ning Guo, Hong‐kai Mei, Rui Liang, Peng‐wei Ma, Wei‐long Wang, Jia‐wei Chen, Zi Wang, Hao Yuan, Yu‐qiang Lun, Wei Gao, Lian‐jun Lu   +10 more
wiley   +1 more source

Synaptic ribbon dynamics after noise exposure in the hearing cochlea

Communications Biology
Moderate noise exposure induces cochlear synaptopathy, the loss of afferent ribbon synapses between cochlear hair cells and spiral ganglion neurons, which is associated with functional hearing decline.
Noura Ismail Mohamad, Peu Santra, Yesai Park, Ian R. Matthews, Emily Taketa, Dylan K. Chan   +5 more
doaj   +1 more source

Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice.

PLoS ONE, 2015
Moderate acoustic overexposure in adult rodents is known to cause acute loss of synapses on sensory inner hair cells (IHCs) and delayed degeneration of the auditory nerve, despite the completely reversible temporary threshold shift (TTS) and ...
Jane Bjerg Jensen, Andrew C Lysaght, M Charles Liberman, Klaus Qvortrup, Konstantina M Stankovic   +4 more
doaj   +1 more source

Erratum to: Dynamics of cochlear synaptopathy after acoustic overexposure [PDF]

Journal of the Association for Research in Otolaryngology, 2015
Erratum to: JARO DOI 10.1007/s10162-015-0510-3 Due to a publishing error during post-acceptance production, the second author (Jun Suzuki) was omitted from the manuscript. The correct author list is as displayed above.
Leslie D. Liberman, Jun Suzuki, M. Charles Liberman   +2 more
openaire   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Comparisons of auditory brainstem response and sound level tolerance in tinnitus ears and non-tinnitus ears in unilateral tinnitus patients with normal audiograms. [PDF]

PLoS ONE, 2017
Recently, "hidden hearing loss" with cochlear synaptopathy has been suggested as a potential pathophysiology of tinnitus in individuals with a normal hearing threshold.
Hyun Joon Shim, Yong-Hwi An, Dong Hyun Kim, Ji Eun Yoon, Ji Hyang Yoon   +4 more
doaj   +1 more source