Results 121 to 130 of about 1,850 (160)

Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness

Nature Communications
Disabling hearing impairment is a common human sensory deficit. OTOF is a major deafness gene. It codes for the synaptic protein otoferlin and is essential for transmitter release by inner hair cells (IHCs).
Tobias Kahland, Dimitri Leonid Lindenwald, Marcus Jeschke, Kathrin Kusch, Olena Tkachenko Eikel, Mara Uhl, Nancy Rüger, Charis Drummer, Bettina Wolf, Fritz Benseler, Nils Brose, Rüdiger Behr, Tobias Moser   +12 more
doaj   +1 more source

Cyclic AMP signaling promotes regeneration of cochlear synapses after excitotoxic or noise trauma

Frontiers in Cellular Neuroscience
IntroductionCochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS).
Sriram Hemachandran, Ning Hu, Catherine J. Kane, Steven H. Green   +3 more
doaj   +1 more source

From hidden hearing loss to supranormal auditory processing by neurotrophin 3-mediated modulation of inner hair cell synapse density.

PLoS Biology
Loss of synapses between spiral ganglion neurons and inner hair cells (IHC synaptopathy) leads to an auditory neuropathy called hidden hearing loss (HHL) characterized by normal auditory thresholds but reduced amplitude of sound-evoked auditory ...
Lingchao Ji, Beatriz C Borges, David T Martel, Calvin Wu, M Charles Liberman, Susan E Shore, Gabriel Corfas   +6 more
doaj   +1 more source

Individual differences in the attentional modulation of the human auditory brainstem response to speech inform on speech-in-noise deficits

Scientific Reports, 2019
People with normal hearing thresholds can nonetheless have difficulty with understanding speech in noisy backgrounds. The origins of such supra-threshold hearing deficits remain largely unclear.
Marina Saiz-Alía, Antonio Elia Forte, Tobias Reichenbach   +2 more
doaj   +1 more source

Toward a Diagnostic Test for Hidden Hearing Loss

Trends in Hearing, 2016
Cochlear synaptopathy (or hidden hearing loss), due to noise exposure or aging, has been demonstrated in animal models using histological techniques. However, diagnosis of the condition in individual humans is problematic because of (a) test reliability ...
Christopher J. Plack, Agnès Léger, Garreth Prendergast, Karolina Kluk, Hannah Guest, Kevin J. Munro   +5 more
doaj   +1 more source

Associations Between Physiological Correlates of Cochlear Synaptopathy and Tinnitus in a Veteran Population. [PDF]

J Speech Lang Hear Res, 2023
Bramhall NF, Theodoroff SM, McMillan GP, Kampel SD, Buran BN.   +4 more
europepmc   +1 more source

Complete Restoration of Hearing Loss and Cochlear Synaptopathy via Minimally Invasive, Single-Dose, and Controllable Middle Ear Delivery of Brain-Derived Neurotrophic Factor–Poly(dl-lactic acid-co-glycolic acid)-Loaded Hydrogel [PDF]

Noise-induced hearing loss (NIHL) often accompanies cochlear synaptopathy, which can be potentially reversed to restore hearing. However, there has been little success in achieving complete recovery of sensorineural deafness using nearly noninvasive ...
Ke Liu (121889), Rui Guo (134395), Yang Li (7082), Dan Jiang (139681), Shusheng Gong (577362), Qianru Yu (14181212), Shengnan Liu (568925), Lan Yin (131556), Kuntao Chen (7147493)   +8 more
core   +1 more source

Neural Response Recovery Despite Persistent Cochlear Synaptopathy After Noise Exposure [PDF]

Synaptopathic noise exposure may preferentially target low-spontaneous rate auditory neurons. Here, we report on two models of noise-induced synaptopathy in gerbil in which hair cells remain intact and two that use higher-level exposures to produce ...
Jeffers, Penelope Williamson Coe
core  

Cochlear Synaptopathy: A Primary Factor Affecting Speech Recognition Performance in Presbycusis. [PDF]

Biomed Res Int, 2021
Chen Z, Zhang Y, Zhang J, Zhou R, Zhong Z, Wei C, Chen J, Liu Y.   +7 more
europepmc   +1 more source

Predicting Cochlear Synaptopathy in Mice with Varying Degrees of Outer Hair Cell Dysfunction Using Auditory Evoked Potentials. [PDF]

J Assoc Res Otolaryngol
Buran BN, Elkins S, He W, Verhulst S, Bramhall NF.   +4 more
europepmc   +1 more source