Results 31 to 40 of about 435 (80)

Binding of mouse cochlin to heparin and its desulfated derivatives.

, 2022
(A) Reporter assay of the interaction between mouse cochlin and several glycosaminoglycans. (B) Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of purified mouse cochlin-Fc fusion protein (mcochlin-Fc).
Karin Murakami (13170657), Tomomi Ichimiya (144479), Tomoko Honda (5732531), Rei Yanagihara (13170654), Shoko Nishihara (144481), Naoki Matsumoto (2007160), Kazuo Yamamoto (391383), Norihito Kawasaki (157096), Ryo Tamura (1957942)   +8 more
core   +1 more source

In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography

, 2015
The expression of cochlin in the trabecular meshwork (TM) precedes the clinical glaucoma symptoms in DBA/2J mice. The ability to quantify cochlin in the local tissue (TM) offers potential diagnostic and prognostic values.
Carreon, Teresia, Wang, Jianhua, Gregori, Giovanni, Bhattacharya, Sanjoy K, Aljohani, Ayman   +4 more
core   +1 more source

First Report of Bilateral External Auditory Canal Cochlin Aggregates (“Cochlinomas”) with Multifocal Amyloid-Like Deposits, Associated with Sensorineural Hearing Loss and a Novel Genetic Variant in COCH Encoding Cochlin [PDF]

, 2020
Pathogenic variants in COCH, encoding cochlin, cause DFNA9 deafness disorder with characteristic histopathologic findings of cochlin deposits in the inner and middle ears.
Basu, Atreyee, Mcphail, Ellen D., Dasari, Surendra, Butz, Malinda, Jethanamest, Daniel, Boczek, Nicole J., Kurtin, Paul J., Robertson, Nahid G., Morton, Cynthia C.; id_orcid, Highsmith, W. Edward, Nasr, Samih H., Zhou, Fang   +11 more
core   +1 more source

Proteomics reveal Cochlin deposits associated with glaucomatous trabecular meshwork

, 2005
The etiology of primary open angle glaucoma, a leading cause of age-related blindness, remains poorly defined, although elevated intraocular pressure (IOP) contributes to the disease progression.
Robertson, Nahid G, Bhattacharya, Sanjoy K, Rockwood, Edward J, Crabb, John W, Morton, Cynthia C, Crabb, John S, Peachey, Neal S, Morton, Cynthia C; id_orcid, Smith, Scott D, Kuchtey, Rachel W, Bonilha, Vera L   +10 more
core   +1 more source

Increased frequencies of cochlin-specific T cells in patients with autoimmune sensorineural hearing loss

, 2006
Autoimmune sensorineural hearing loss (ASNHL) is the most common cause of sudden hearing loss in adults. Although autoimmune etiopathogenic events have long been suspected in ASNHL, inner ear-specific Ags capable of targeting T cell autoreactivity have ...
Jaini, Ritika, Robertson, Nahid G, Hughes, Gordon B, Johnson, Justin M, Park, Hyun-Min, Solares, C Arturo, Tuohy, Vincent K, Altuntas, Cengiz Z, Ball, Edward J, Thomas, Dawn M, Jane-Wit, Daniel, Morton, Cynthia C; id_orcid, Baek, Moo-Jin   +12 more
core   +6 more sources

Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility. [PDF]

, 2011
Fluid flow through large interstitial spaces is sensed at the cellular level, and mechanistic responses to flow changes enables expansion or contraction of the cells modulating the surrounding area and brings about changes in fluid flow.
Sienkiewicz, Adam E, Picciani, Renata, Manik Goel, Goel Manik, Richard K Lee, Picciani Renata, Lee Richard K., Adam E. Sienkiewicz, Lee, Richard K, Sanjoy K. Bhattacharya, Adam E Sienkiewicz, Bhattacharya Sanjoy K., Renata Picciani, Goel, Manik, Sanjoy K Bhattacharya, Richard K. Lee, Sienkiewicz Adam E., Bhattacharya, Sanjoy K   +17 more
core   +1 more source

Interaction of cochlin and mechanosensitive channel TREK-1 in trabecular meshwork cells influences the regulation of intraocular pressure. [PDF]

, 2017
This work was funded by National Institute of Health Grants R01 EY016112, EY015266, and EY014801 and an unrestricted grant to the University of Miami's Bascom Palmer Eye Institute from Research to Prevent Blindness. Financial support from Fight for Sight
Carreon, Teresia A., Teresia A. Carreon, Aida Castellanos, Xavier Gasull, Castellanos, Aida, Bhattacharya, Sanjoy K., Gasull Casanova, Xavier, Sanjoy K. Bhattacharya, Bhattacharya, Sanjoy K, Carreon, Teresia A, Gasull, Xavier   +10 more
core   +1 more source

Down-regulation and/or disruption of cochlin expression in mice TM is commensurate with reduction in mean IOP.

, 2012
(A) Agarose gel (1.2%) showing the absence of PCR products for exons 8, 10 and 11 in the DBA/2J cochlin−/− mice. These exons are present in DBA/2J cochlin+/+ and cochlin+/− mice.
Renata Picciani (173483), Jianhua Wang (159545), Richard K. Lee (169906), Sanjoy K. Bhattacharya (158939), Manik Goel (173467), Adam E. Sienkiewicz (173476)   +5 more
core   +1 more source

Cochlin: a surprise element in immune defense of the brain

Brain function can be severely impacted by infectious disease and the inflammatory sequelae. The brain is thus well defended by barriers. Circumventricular organs (CVOs) lack one of the defences, namely the blood-brain barrier, and are vulnerable to ...
Ghosh, Raghumoy
core   +1 more source

Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear

, 2019
In the inner ear, endolymph fluid surrounds the organ of Corti, which is important for auditory function; notably, even slight environmental changes mediated by trauma or infection can have significant consequences.
윤상선, 윤주헌, 이강무, 정진세, 현영민, 최재영, 김성헌   +6 more
core   +1 more source