Results 21 to 30 of about 435 (80)

Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. [PDF]

Immunity, 2013
SummaryCochlin, an extracellular matrix protein, shares homologies with the Factor C, a serine protease found in horseshoe crabs, which is critical for antibacterial responses.
Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J.   +13 more
europepmc   +2 more sources

Establishment of cochlin reporter cells and domain organization of cochlin showing point mutations of DFNA9 patients.

, 2022
(A) Expression plasmid for the expression of chimeric cochlin/CD8α/CD3ζ protein. (B) Schematic illustration of the cochlin reporter cell, cochlin-BWZ.
Karin Murakami (13170657), Tomomi Ichimiya (144479), Tomoko Honda (5732531), Rei Yanagihara (13170654), Shoko Nishihara (144481), Naoki Matsumoto (2007160), Kazuo Yamamoto (391383), Norihito Kawasaki (157096), Ryo Tamura (1957942)   +8 more
core   +1 more source

Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor [PDF]

, 2021
Here, we report that important regulators of cilia formation and ciliary compartment–directed protein transport function in secretion polarity. Mutations in cilia genes cep290 and bbs2, involved in human ciliopathies, affect apical secretion of Cochlin ...
Nikolaeva, Y., Zhu, Z., Markham, E., Van Eeden, F., Malicki, J., Hirst, R.A., Leventea, E., Fang, X.   +7 more
core   +1 more source

Cochlin in normal middle ear and abnormal middle ear deposits in DFNA9 and Coch (G88E/G88E) mice. [PDF]

J Assoc Res Otolaryngol, 2014
DFNA9 sensorineural hearing loss and vestibular disorder, caused by mutations in COCH, has a unique identifying histopathology including prominent acellular deposits in cochlear and vestibular labyrinths.
Robertson NG, O'Malley JT, Ong CA, Giersch AB, Shen J, Stankovic KM, Morton CC.   +6 more
europepmc   +2 more sources

Cochlin, intraocular pressure regulation and mechanosensing. [PDF]

, 2012
Fluid shear modulates many biological properties. How shear mechanosensing occurs in the extracellular matrix (ECM) and is transduced into cytoskeletal change remains unknown. Cochlin is an ECM protein of unknown function.
Renata Picciani (173483), Sienkiewicz, Adam E, Picciani, Renata, Manik Goel, Goel Manik, Wang Jianhua, Richard K Lee, Picciani Renata, Lee Richard K., Jianhua Wang (159545), Sanjoy K. Bhattacharya (158939), Lee, Richard K, Adam E Sienkiewicz, Manik Goel (173467), Adam E. Sienkiewicz (173476), Bhattacharya Sanjoy K., Renata Picciani, Goel, Manik, Jianhua Wang, Sanjoy K Bhattacharya, Sienkiewicz Adam E., Wang, Jianhua, Richard K. Lee (169906), Bhattacharya, Sanjoy K   +23 more
core   +1 more source

2.　Cochlin-tomoprotein (CTP) が切り拓く難聴、めまい診療の未来

Nihon Jibi Inkoka Tokeibu Geka Gakkai Kaiho
exaly   +2 more sources

The effects of cochlin dimerization and GAG sulfation on their binding.

, 2022
GAG binding is maximized in wild-type cochlin homodimers (left). Dimers formed between wild-type cochlin and mutated cochlin (middle) as well as a cysteine substitution in cochlin (C542F) that inhibits dimer formation via a disulfide bridge (right ...
Karin Murakami (13170657), Tomomi Ichimiya (144479), Tomoko Honda (5732531), Rei Yanagihara (13170654), Shoko Nishihara (144481), Naoki Matsumoto (2007160), Kazuo Yamamoto (391383), Norihito Kawasaki (157096), Ryo Tamura (1957942)   +8 more
core   +1 more source

Ultrastructural localization of cochlin in the rat cochlear duct [PDF]

, 2009
浜松医科大学博士（医学）浜松医科大学学位論文 医博論第474号(平成21年12月11日)doctoral医学系研究科Cochlin, a product of the COCH gene, is a major constituent of the inner ear extracellular matrix. Type II collagen, a protein that contributes to structural stability, is similarly a component of
Hosokawa, Seiji
core   +2 more sources

Cochlin and glaucoma: A mini-review

, 2005
Primary open angle glaucoma (POAG) is a leading cause of late onset, progressive, irreversible blindness and, although its etiology is poorly understood, elevated intraocular pressure (IOP) often appears to be a contributory factor. Proteomic and Western
CRABB, JOHN W, BHATTACHARYA, SANJOY K, PEACHEY, NEAL S   +2 more
core   +1 more source

Cochlin mechanosensing and proposed model of potential associated TM changes.

, 2012
(A) Western analysis of purified recombinant cochlin (*) using anti-cochlin antibody before after sheer stress, revealing shear stress-induced mulitmers. Cochlin was subjected to fluid shear of 3 µl/min for 150 cycles.
Renata Picciani (173483), Jianhua Wang (159545), Richard K. Lee (169906), Sanjoy K. Bhattacharya (158939), Manik Goel (173467), Adam E. Sienkiewicz (173476)   +5 more
core   +1 more source