Results 111 to 120 of about 2,037,717 (291)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

CodeGen-3D: A Benchmark for Evaluating LLMs in Zero-Shot and Iterative 3D Modeling in Blender

IEEE Access
Large Language Models (LLMs) that generate executable code are opening a new path to text-to-3D by converting natural language prompts into scripts for modeling software like Blender.
Hao Ji, Kotha Aditya, Sebastian Escalante, Yunjian Qiu   +3 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

RateML: A Code Generation Tool for Brain Network Models. [PDF]

Front Netw Physiol, 2022
van der Vlag M, Woodman M, Fousek J, Diaz-Pier S, Pérez Martín A, Jirsa V, Morrison A.   +6 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Program Code Generation with Generative AIs

Algorithms
Our paper compares the correctness, efficiency, and maintainability of human-generated and AI-generated program code. For that, we analyzed the computational resources of AI- and human-generated program code using metrics such as time and space ...
Baskhad Idrisov, Tim Schlippe
doaj   +1 more source

QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Matthews RJ, Hollinshead D, Morrison D, van der Graaf PH, Kierzek AM.   +4 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Recent Advances in Intelligent Source Code Generation: A Survey on Natural Language Based Studies. [PDF]

Entropy (Basel), 2021
Yang C, Liu Y, Yin C.
europepmc   +1 more source

IGGy: An interactive environment for surface grid generation [PDF]

A graphically interactive derivative of the EAGLE boundary code is presented. This code allows the user to interactively build and execute commands and immediately see the results. Strong ties with a batch oriented script language are maintained.
Prewitt, Nathan C.
core   +1 more source