QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2023 Matthews RJ +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Recent Advances in Intelligent Source Code Generation: A Survey on Natural Language Based Studies. [PDF]
Entropy (Basel), 2021 Yang C, Liu Y, Yin C.
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
XBoot: A RAPID and Instructional Low-Code Generator for Spring Boot Applications
Applied SciencesDeveloping secure and well-structured web applications using Spring Boot presents a significant challenge, as it requires developers to manage multiple layers, employ framework-specific annotations, and ensure authentication, authorization, and ...
Basem Y. Alkazemi, Mohamed K. Nour
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Compiler-Like Code Generation for fUML: Reducing Overhead in Executable UML
IEEE AccessfUML is a specification developed by the Object Management Group (OMG) that defines precise execution semantics as well as a respective execution environment for a subset of the Unified Modeling Language (UML).
Maximilian Hammer +2 more
doaj +1 more source
cellmlmanip and chaste_codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians. [PDF]
Wellcome Open Res, 2021 Hendrix M +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Evaluation of human and AI cooperation in pair programming on the example of CodeLlama and GPT-4
Ìнформаційні технології та компʼютерна інженеріяThe aim of the study was the experimental evaluation of the effectiveness of human interaction with large artificial intelligence language models during the completion of programming tasks in a pair programming format. The two models compared were GPT-4,
O. Deineha, O. Arshava, I. Zhovtonizhko
doaj +1 more source