Results 141 to 150 of about 11,564,024 (351)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Hierarchical Transmission of Huffman Code Using Multi-Code/Multi-Rate DS/SS Modulation with Appropriate Power Control [PDF]

, 1998
For transmission of video signals, it is important that the system allows a certain degree of flexibility in bit rate as well as quality, depending upon the requirements of media and channel conditions.
Yamazato, Takaya, Ogawa, Akira, Makido, Satoshi, Katayama, Masaaki   +3 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Code-Imp: a tool for automated search-based refactoring

, 2011
Manual refactoring is tedious and error-prone, so it is natural to try to automate this process as much as possible. Fully automated refactoring usually involves using metaheuristic search to determine which refactorings should be applied to improve the ...
Hemati-Moghadam, Iman, Ó Cinnéide, Mel, Mel Ó Cinnéide (12618964), Iman Hemati-Moghadam (12619600)   +3 more
core  

Evaluating Embedding Representations for Multiclass Code Smell Detection: A Comparative Study of CodeBERT and General-Purpose Embeddings

Applied Sciences
Code smells are indicators of potential design problems in software systems and are commonly used to guide refactoring activities. Recent advances in representation learning have enabled the use of embedding-based models for analyzing source code ...
Marcela Mosquera, Rodolfo Bojorque
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Cloud-assisted LLM-enhanced datasets for AST hierarchy-aware code summarization model

Journal of Cloud Computing: Advances, Systems and Applications
Code summarization is an important task in software engineering that helps developers understand and maintain code by generating natural language summaries.
Junsan Zhang, Yudie Yan, Junxiao Han, Ao Lu, Juncai Guo, Javad Pourzamani   +5 more
doaj   +1 more source

What improves developer productivity at google? code quality

ESEC/SIGSOFT FSE, 2022
Lan Cheng, E. Murphy-Hill, Mark Canning, Ciera Jaspan, Collin Green, Andrea Knight, Nan Zhang, Elizabeth Kammer   +7 more
semanticscholar   +1 more source