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Synthesis of (±)-Codeine [PDF]
Synfacts, 2009 International ...
Varin, M. +3 more
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To Prescribe Codeine or Not to Prescribe Codeine?
Journal of Pain & Palliative Care Pharmacotherapy, 2014A recently published study in Pediatrics by Kaiser et al. (2014; Epub April 21, DOI: 10.1542/peds.2013-3171) reported that on average, over the past decade, children aged 3 to 17 were prescribed approximately 700,000 prescriptions for codeine-containing products each year in association with emergency department (ED) visits.
Marc L. Fleming, Matthew A. Wanat
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Is it farewell to codeine? [PDF]
Archives of Disease in Childhood, 2013 Codeine was considered a suitable analgesic for children after adenotonsillectomy. It has been used extensively in the UK1 for over 40 years and appeared effective.2 It was listed in the WHO as the second step on the Analgesic Ladder for the treatment of cancer pain.
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Blood Codeine Concentrations in Fatalities Associated with Codeine
Clinical Toxicology, 1975The toxicologic findings in eight cases of death due primarily to codeine overdosage are presented. Blood codeine concentrations ranged from 1.4 to 5.6 mug/ml as determined by gas-liquid chromatography. Morphine was found in only two of the blood samples, at concentrations of 0.2 and 0.6 mug/ml, and may have resulted from heroin usage rather than ...
James A. Wright +2 more
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ChemInform Abstract: CONVERSION OF THEBAINE TO CODEINE [PDF]
Chemischer Informationsdienst, 1976 AbstractThebain (II) wird mit Natrium‐tert.‐butylmercaptid zu dem Substitutionsprodukt (I) und Oripavin umgesetzt.
Henry Rapoport, Randy B. Barber
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The pharmacogenetics of codeine hypoalgesia
Pharmacogenetics, 1995Codeine is an old drug that is still widely used to treat mild and moderate pain. It is mainly metabolised by glucuronidation, but minor pathways are N-demethylation to norcodeine and O-demethylation to morphine. The latter pathway depends on the genetically polymorphic CYP2D6 which is absent in 7% of the white population (PM) and present in the ...
Søren H. Sindrup, Kim Brøsen
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Fenoprofen and codeine analgesia
Clinical Pharmacology and Therapeutics, 1981Studies were conducted on postpartum and postoperative patients to estimate the dose-response line of fenoprofen and to contrast it with codeine and placebo. The postpartum patients included women with episiotomy pain and with uterine cramping. This mix allowed contrast of ability of the various pain models to distinguish codeine from placebo.
Eugene M. Laska, Abraham Sunshine
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