Results 111 to 120 of about 40,508 (295)
, 1990 Editorial : Codification(s). In: Politix, vol. 3, n°10-11, Deuxième et troisième trimestre 1990. Codification(s) sous la direction de Bastien François et Jean-Philippe Heurtin.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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Armed Crimes in the 19th-Century Criminal Codifications of Hungary
Journal on European History of LawArmed crimes have been present in the criminal law of Hungary for a long time, however their existence was not substantial without having codified criminal law. During the late 18th century when the first codification took place, armed crimes and crimes
Mariann Minkó-Miskovics
doaj
Codification of legislation or codification of law: statement of the problem
Vestnik Yaroslavskogo gosudarstvennogo universiteta im. P. G. Demidova. Seriya gumanitarnye naukiThe publication is devoted to the problem of choosing a formulation that most fully reveals the nature of legal codification. Basically, researchers write either about the codification of legislation or about the codification of law. A number of works also talk about the codification of legislative norms or legal norms.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
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Reflections on Codification History
Gdańskie Studia PrawniczeGiven the importance of codifications, further research on them is needed, including a re-evaluation of existing studies. Even if we distinguish between true codifications and compilations, existing definitions are problematic. Getting around this problem by using the French 1804 Civil Code as a model does not help, as it was an atypical text.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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The American Codification Movement
, 1983 Between 1820 and 1850 American legal commentators became obsessed with whether legislatures should codify, either in whole or in part, the common law of the American states.
Gordon, Robert W.
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