Results 81 to 90 of about 241,954 (329)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Codified-Tacit and General-Specific Knowledge in the division of labour among firms. A study of the Software Industry [PDF]
This paper addresses the organisation and codification of knowledge in the software industry. It analyses various economic incentives to codification, including the need to improve the productivity and quality of software production processes and to ...
Rosa Grimaldi, Salvatore Torrisi
core
International Crimes: Jus Cogens and Obligatio Erga Omnes [PDF]
, 1996 There are both gaps and weaknesses in the various sources of International Criminal Law in norms and enforcement modalities.
Bassiouni, M. Cherif
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Miscellanea Hadriatica et Mediterranea, 2017 This paper presents the principal characteristics of the development of the law of the sea in the Mediterranean, from the initial historical sources to the Third UN Conference on the Law of the Sea (1982).
Marina Vokić Žužul, Božena Bulum
doaj +1 more source
Knowledge and reasonableness [PDF]
, 2020 The notion of relevance plays a role in many accounts of knowledge and knowledge ascription. Although use of the notion is well-motivated, theorists struggle to codify relevance.
Lawlor, Krista
core
Driving Cars by Means of Genetic Algorithms [PDF]
, 2008 Proceedings of: 10th International Conference on Parallel Problem Solving From Nature, PPSN 2008. Dortmund, Germany, September 13-17, 2008The techniques and the technologies supporting Automatic Vehicle Guidance are an important issue.
Isasi, Pedro +3 more
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Vilnius University Open Series, 2020 This article discusses the EU legislation, regarding main procedural rights of economic operators applied in the supervision procedure of their activities and its impact on supervisory procedures in Lithuania, as well as the institute of supervision of ...
Eimantė Šilvaitė
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source