Codon usage in vertebrates is associated with a low risk of acquiring nonsense mutations [PDF]
Journal of Translational Medicine, 2011 Background Codon usage in genomes is biased towards specific subsets of codons. Codon usage bias affects translational speed and accuracy, and it is associated with the tRNA levels and the GC content of the genome.
Flegel Willy A, Schmid Pirmin
doaj +5 more sources
Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine
Cell Death and Disease, 2022 TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) induces full-length p53 in human tumor cells carrying R213X nonsense mutant TP53.
Mireia Palomar-Siles +12 more
doaj +2 more sources
Interaction of nonsense suppressor tRNAs and codon nonsense mutations or termination codons
Advances in Biological Chemistry, 2012 Codon nonsense mutations include amber, ochre, or opal mutations according to termination codon consisting of three types (TAG, TAA and TGA). Codon nonsense mutations are also divided into natural and artificial mutations. We discussed the interaction of
Lu Zixian
semanticscholar +4 more sources
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations
Nature Communications, 2020 Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.
Carole Trzaska +21 more
doaj +2 more sources
BMC Cancer, 2019 Background Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are
Duan Chu, Lai Wei
doaj +2 more sources
A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies. [PDF]
PLoS ONE, 2018 Nonsense mutations are present in 10% of patients with CF, produce a premature termination codon in CFTR mRNA causing early termination of translation, and lead to lack of CFTR function.
Daniel R McHugh +9 more
doaj +2 more sources
CGG: an unassigned or nonsense codon in Mycoplasma capricolum. [PDF]
Proceedings of the National Academy of Sciences, 1991 CGG is an arginine codon in the universal genetic code. We previously reported that in Mycoplasma capricolum, a relative of Gram-positive eubacteria, codon CGG did not appear in coding frames, including termination sites, and tRNA(ArgCCG) pairing with ...
Takanori Oba +3 more
semanticscholar +4 more sources
Extended stop codon context predicts nonsense codon readthrough efficiency in human cells
Nature CommunicationsProtein synthesis terminates when a stop codon enters the ribosome’s A-site. Although termination is efficient, stop codon readthrough can occur when a near-cognate tRNA outcompetes release factors during decoding.
Kotchaphorn Mangkalaphiban +6 more
doaj +3 more sources
Infrequent translation of a nonsense codon is sufficient to decrease mRNA level. [PDF]
Molecular Biology of the Cell, 1999 In many organisms nonsense mutations decrease the level of mRNA. In the case of mammalian cells, it is still controversial whether translation is required for this nonsense-mediated RNA decrease (NMD).
Alla Buzina, Marc J. Shulman
semanticscholar +3 more sources
Nonsense Mutations in Close Proximity to the Initiation Codon Fail to Trigger Full Nonsense-mediated mRNA Decay* [PDF]
Journal of Biological Chemistry, 2004 Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs containing premature translation termination codons. In mammalian cells, a termination codon is ordinarily recognized as "premature" if it is located greater than 50-54 nucleotides 5' to the final exon-exon junction.
Â. Inácio +9 more
semanticscholar +5 more sources