Results 1 to 10 of about 171,776 (184)

Codon usage in vertebrates is associated with a low risk of acquiring nonsense mutations [PDF]

open access: yesJournal of Translational Medicine, 2011
Background Codon usage in genomes is biased towards specific subsets of codons. Codon usage bias affects translational speed and accuracy, and it is associated with the tRNA levels and the GC content of the genome.
Flegel Willy A, Schmid Pirmin
doaj   +5 more sources

Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

open access: yesCell Death and Disease, 2022
TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) induces full-length p53 in human tumor cells carrying R213X nonsense mutant TP53.
Mireia Palomar-Siles   +12 more
doaj   +2 more sources

Interaction of nonsense suppressor tRNAs and codon nonsense mutations or termination codons

open access: yesAdvances in Biological Chemistry, 2012
Codon nonsense mutations include amber, ochre, or opal mutations according to termination codon consisting of three types (TAG, TAA and TGA). Codon nonsense mutations are also divided into natural and artificial mutations. We discussed the interaction of
Lu Zixian
semanticscholar   +4 more sources

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

open access: yesNature Communications, 2020
Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.
Carole Trzaska   +21 more
doaj   +2 more sources

Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation

open access: yesBMC Cancer, 2019
Background Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are
Duan Chu, Lai Wei
doaj   +2 more sources

A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies. [PDF]

open access: yesPLoS ONE, 2018
Nonsense mutations are present in 10% of patients with CF, produce a premature termination codon in CFTR mRNA causing early termination of translation, and lead to lack of CFTR function.
Daniel R McHugh   +9 more
doaj   +2 more sources

CGG: an unassigned or nonsense codon in Mycoplasma capricolum. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1991
CGG is an arginine codon in the universal genetic code. We previously reported that in Mycoplasma capricolum, a relative of Gram-positive eubacteria, codon CGG did not appear in coding frames, including termination sites, and tRNA(ArgCCG) pairing with ...
Takanori Oba   +3 more
semanticscholar   +4 more sources

Extended stop codon context predicts nonsense codon readthrough efficiency in human cells

open access: yesNature Communications
Protein synthesis terminates when a stop codon enters the ribosome’s A-site. Although termination is efficient, stop codon readthrough can occur when a near-cognate tRNA outcompetes release factors during decoding.
Kotchaphorn Mangkalaphiban   +6 more
doaj   +3 more sources

Infrequent translation of a nonsense codon is sufficient to decrease mRNA level. [PDF]

open access: yesMolecular Biology of the Cell, 1999
In many organisms nonsense mutations decrease the level of mRNA. In the case of mammalian cells, it is still controversial whether translation is required for this nonsense-mediated RNA decrease (NMD).
Alla Buzina, Marc J. Shulman
semanticscholar   +3 more sources

Nonsense Mutations in Close Proximity to the Initiation Codon Fail to Trigger Full Nonsense-mediated mRNA Decay* [PDF]

open access: yesJournal of Biological Chemistry, 2004
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs containing premature translation termination codons. In mammalian cells, a termination codon is ordinarily recognized as "premature" if it is located greater than 50-54 nucleotides 5' to the final exon-exon junction.
Â. Inácio   +9 more
semanticscholar   +5 more sources

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