Results 221 to 230 of about 69,317 (259)
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Nonsense codons and polarity in the tryptophan operon
Journal of Molecular Biology, 1966Abstract Amber and ochre mutants and mutants with cross-reacting material for all five genes of the tryptophan operon have been isolated and characterized. Co-ordinate enzyme formation was examined under repression conditions with a repressordeficient stock of each mutant.
C, Yanofsky, J, Ito
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The BRCA2 polymorphic stop codon: stuff or nonsense?
Journal of Medical Genetics, 2015Background Despite classification of the BRCA2c.9976A>T, p.(Lys3326Ter) variant as a polymorphism, it has been associated with increased risks of pancreatic, lung, oesophageal and breast cancer. Methods We have noticed multiple co-occurrences of ...
Higgs, J E +7 more
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Yeast mitochondrial tRNATrp can recognize the nonsense codon UGA
Nature, 1980DNA sequence analysis of mitochondrial genes that code for some mitochondrial proteins has suggested that the opal terminator, UGA, is used as a sense codon in mitochondria. The complete sequences of both the yeast and human genes coding for cytochrome oxidase subunit II contain UGA codons in the reading frame.
N C, Martin +4 more
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Sense from nonsense: therapies for premature stop codon diseases
Trends in Molecular Medicine, 2012Ten percent of inherited diseases are caused by premature termination codon (PTC) mutations that lead to degradation of the mRNA template and to the production of a non-functional, truncated polypeptide. In addition, many acquired mutations in cancer introduce similar PTCs.
Laure, Bidou +3 more
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Identification of nonsense codons in yeast
Journal of Molecular Biology, 1969Abstract Two nonsense codons have been found in Saccharomyces cerevisiae . The codons differ by a single base and only one contains guanine. Accepting the universality of the genetic code, one can deduce that these are amber and ochre codons since there exist suppressors capable of acting upon either class of nonsense alleles.
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Codon context effects on nonsense suppression in human cells
Biochemical Society Transactions, 1993Carter, P. W., Hartkus, J. M. and Calvo, J. M. (1986) Proc.Natl.Acad.Sci. U.S.A.83,8127-8131 Gabain, A. v., Helasco, J. G.. Schottel, J. I,., Chang, A. C. Y. and Cohen. S. N. (1983) Proc. Natl. Acad. Sci. [J.S.A. 80, 653-657 Petersen, C. (1987) MGG Mol. Gen. Genet. 209, 179187 Spaniard. K. A., Chen, K., Walker, J. K. and van Lhin, J.
R, Martin +3 more
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Nonsense-codon-mediated decay in human hereditary complement C3 deficiency
Immunogenetics, 2004C3 occupies a central position in the complement pathway, mediating such diverse functions as convertase activity, opsonization and anaphylotoxin production. The deficiency of this protein is a rare autosomal recessive inherited disease, characterized by severe recurrent infections and immune complex disorders.
Edimara S, Reis +2 more
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Effects of surrounding sequence on the suppression of nonsense codons
Journal of Molecular Biology, 1983Using a lacI-Z fusion system, we have determined the efficiency of suppression of nonsense codons in the I gene of Escherichia coli by assaying beta-galactosidase activity. We examined the efficiency of four amber suppressors acting on 42 different amber (UAG) codons at known positions in the I gene, and the efficiency of a UAG suppressor at 14 ...
MILLER J. H, ALBERTINI, ALESSANDRA
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The association of nonsense codons with exon skipping
Mutation Research/Reviews in Mutation Research, 1998Some genes that contain premature nonsense codons express alternatively-spliced mRNA that has skipped the exon containing the nonsense codon. This paradoxical association of translation signals (nonsense codons) and RNA splicing has inspired numerous explanations. The first is based on the fact that premature nonsense codons often reduce mRNA abundance.
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1995
Abstract The genomic G + C content of Micrococcus luteus is 75 per cent, the highest of all the organisms that have been examined. Figure 4.1 shows that codons ending with G or C comprise 95 to 100 per cent of all codons (Obama et al., 1990a). In the NNY pair, use of the NNC codon does not reach 100 per cent, and a small amount of NNU is
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Abstract The genomic G + C content of Micrococcus luteus is 75 per cent, the highest of all the organisms that have been examined. Figure 4.1 shows that codons ending with G or C comprise 95 to 100 per cent of all codons (Obama et al., 1990a). In the NNY pair, use of the NNC codon does not reach 100 per cent, and a small amount of NNU is
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