Results 231 to 240 of about 133,000 (265)
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1995
Abstract The genomic G + C content of Micrococcus luteus is 75 per cent, the highest of all the organisms that have been examined. Figure 4.1 shows that codons ending with G or C comprise 95 to 100 per cent of all codons (Obama et al., 1990a). In the NNY pair, use of the NNC codon does not reach 100 per cent, and a small amount of NNU is
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Abstract The genomic G + C content of Micrococcus luteus is 75 per cent, the highest of all the organisms that have been examined. Figure 4.1 shows that codons ending with G or C comprise 95 to 100 per cent of all codons (Obama et al., 1990a). In the NNY pair, use of the NNC codon does not reach 100 per cent, and a small amount of NNU is
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Orientation of Nonsense Codons on the Genetic Map of the Lac Operon
Science, 1967Intracodon recombination is used to orient the nonsense codons UGA, UAG, and UAA on the genetic map of the (lactose) lac operon of Escherichia coli . The 5′-end of these triplets is toward the operator end of the operon.
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Reversion of trpA nonsense mutations by deletion of the chain-termination codons
Biochimie, 1989This paper describes a novel mechanism for reversion of nonsense mutations in the trpA gene of Escherichia coli. This mechanism, deletion of the nonsense codon, was discovered in the course of selecting for missense revertants of trpA(UGA211) and for catalytically active tryptophan synthetase alpha chain revertants of trpA(UAA234) and trpA(UAG234 ...
S D, Tucker, E J, Murgola, K A, Hijazi
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Sense from nonsense: therapies for premature stop codon diseases
Trends in Molecular Medicine, 2012Ten percent of inherited diseases are caused by premature termination codon (PTC) mutations that lead to degradation of the mRNA template and to the production of a non-functional, truncated polypeptide. In addition, many acquired mutations in cancer introduce similar PTCs.
Laure, Bidou +3 more
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Yeast mitochondrial tRNATrp can recognize the nonsense codon UGA
Nature, 1980DNA sequence analysis of mitochondrial genes that code for some mitochondrial proteins has suggested that the opal terminator, UGA, is used as a sense codon in mitochondria. The complete sequences of both the yeast and human genes coding for cytochrome oxidase subunit II contain UGA codons in the reading frame.
N C, Martin +4 more
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Nonsense-codon-mediated decay in human hereditary complement C3 deficiency
Immunogenetics, 2004C3 occupies a central position in the complement pathway, mediating such diverse functions as convertase activity, opsonization and anaphylotoxin production. The deficiency of this protein is a rare autosomal recessive inherited disease, characterized by severe recurrent infections and immune complex disorders.
Edimara S, Reis +2 more
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A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding
Nature Chemical BiologyPseudouridine (Ψ) is known for decades but its flexibility in base pairing remains unclear. This study engineers artificial box H/ACA guide RNAs to direct pseudouridylation at the uridine of a premature termination codon (PTC; UAA, UAG or UGA) within an intronless mRNA and U36 of the anticodon of a matching tRNA in yeast and human cells.
Yi Pan +4 more
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Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes
Molecular Cell, 2023Pedro Morais, Yi-Tao Yu, Hironori Adachi
exaly
Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAs
Molecular Therapy - Nucleic Acids, 2022John Lueck, Wooree Ko, Joseph J Porter
exaly
Readthrough compounds for nonsense mutations: bridging the translational gap
Trends in Molecular Medicine, 2023Jeffrey Beekman
exaly