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Release factor competition is equivalent at strong and weakly suppressed nonsense codons
Molecular and General Genetics MGG, 1988We have compared the competition between strong or weak suppressor tRNAs and translational release factors (RF) at nonsense codons in the lacI gene of Escherichia coli. Using the F'lacIZ fusions developed by Miller and coworkers, UAG, UAA, and UGA codons at positions 189 and 220 were efficiently suppressed by plasmid-borne tRNA(trp) suppressors cognate
Robin Martin+3 more
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Nonsense-codon-mediated decay in human hereditary complement C3 deficiency
Immunogenetics, 2004C3 occupies a central position in the complement pathway, mediating such diverse functions as convertase activity, opsonization and anaphylotoxin production. The deficiency of this protein is a rare autosomal recessive inherited disease, characterized by severe recurrent infections and immune complex disorders.
Lourdes Isaac, E. S. Reis, V. Nudelman
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Molecular and General Genetics MGG, 1981
The extreme polarity shown by operator proximal nonsense mutations in the lacZ gene and the resulting lack of full-length lacZ mRNA have been used to estimate transcriptional errors at such a locus. The resudual β-galactosidase activity in strains carrying lacZ 2 or the same allele with a rho mutation indicate an RNA polymerase error rate of 1.4×10-4.
Gillian Foskett, R. F. Rosenberger
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The extreme polarity shown by operator proximal nonsense mutations in the lacZ gene and the resulting lack of full-length lacZ mRNA have been used to estimate transcriptional errors at such a locus. The resudual β-galactosidase activity in strains carrying lacZ 2 or the same allele with a rho mutation indicate an RNA polymerase error rate of 1.4×10-4.
Gillian Foskett, R. F. Rosenberger
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TIBS -Trends in Biochemical Sciences. Regular ed, 1998
Eszter Nagy, L. Maquat
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Eszter Nagy, L. Maquat
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1995
Abstract The genomic G + C content of Micrococcus luteus is 75 per cent, the highest of all the organisms that have been examined. Figure 4.1 shows that codons ending with G or C comprise 95 to 100 per cent of all codons (Obama et al., 1990a). In the NNY pair, use of the NNC codon does not reach 100 per cent, and a small amount of NNU is
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Abstract The genomic G + C content of Micrococcus luteus is 75 per cent, the highest of all the organisms that have been examined. Figure 4.1 shows that codons ending with G or C comprise 95 to 100 per cent of all codons (Obama et al., 1990a). In the NNY pair, use of the NNC codon does not reach 100 per cent, and a small amount of NNU is
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[Nonsense codon is not stop codon].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1993openaire +1 more source