Results 91 to 100 of about 36,414 (291)
Selection on Codon Usage for Error Minimization at the Protein Level [PDF]
, 2018 Given the structure of the genetic code, synonymous codons differ in their capacity to minimize the effects of errors due to mutation or mistranslation.
Archetti, Marco
core
Advanced Science, EarlyView.CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu +13 more
wiley +1 more source
Evolutionary rates and gene dispensability associate with replication timing in the Archaeon Sulfolobus islandicus [PDF]
, 2010 In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution.
Cooper, Vaughn S. +3 more
core +2 more sources
Advanced Science, EarlyView.Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han +10 more
wiley +1 more source
Codon usage of host-specific P genotypes (VP4) in group A rotavirus
BMC Genomics, 2022 Background Group A rotavirus (RVA) is a common causative agent of acute gastroenteritis in infants and young children worldwide. RVA P genotypes, determined by VP4 sequences, have been confirmed to infect humans and animals.
Han Wu +5 more
doaj +1 more source
Codon Usage Bias and Mutation Constraints Reduce the Level of ErrorMinimization of the Genetic Code [PDF]
, 2018 Studies on the origin of the genetic code compare measures of the degree of error minimization of the standard code with measures produced by random variant codes but do not take into account codon usage, which was probably highly biased during the ...
Archetti, Marco
core
Differential Functional Constraints Cause Strain-Level Endemism in Polynucleobacter Populations. [PDF]
, 2016 The adaptation of bacterial lineages to local environmental conditions creates the potential for broader genotypic diversity within a species, which can enable a species to dominate across ecological gradients because of niche flexibility.
Geeta Rijal +8 more
core +2 more sources
The effect of context on synonymous codon usage in genes with low codon usage bias
Nucleic Acids Research, 1990 The effect of neighbouring bases on the usage of synonymous codons in genes with low codon usage bias in yeast and E. coli is examined. The codon adaptation index is employed to identify a group of genes in each organism with low codon usage bias, which are likely to be weakly expressed.
openaire +3 more sources
Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine
Advanced Science, EarlyView.This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng +18 more
wiley +1 more source
Data in support of large scale comparative codon usage analysis in Leishmania and Trypanosomatids
Data in Brief, 2015 This data article contains data related to the article “Comparison of codon usage bias across Leishmania and Trypanosomatids to understand mRNA secondary structure, relative protein abundance and pathway functions” by Subramanian and Sarkar, Genomics ...
Abhishek Subramanian, Ram Rup Sarkar
doaj +1 more source