Results 81 to 90 of about 18,552 (255)

A Comparative Analysis of Synonymous Codon Usage Bias Pattern in Human Albumin Superfamily

The Scientific World Journal, 2014
Synonymous codon usage bias is an inevitable phenomenon in organismic taxa across the three domains of life. Though the frequency of codon usage is not equal across species and within genome in the same species, the phenomenon is non random and is tissue-
Hoda Mirsafian, Adiratna Mat Ripen, Aarti Singh, Phaik Hwan Teo, Amir Feisal Merican, Saharuddin Bin Mohamad   +5 more
doaj   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Biological Resectability in Colorectal Liver Metastases: A Nomogram‐Based Continuous Risk Model to Define Borderline Disease

Annals of Gastroenterological Surgery, EarlyView.
KRAS mutation demonstrated a prognostic impact according to primary tumor sidedness, independent of tumor morphology, in patients undergoing hepatectomy for colorectal liver metastases. A nomogram integrating biological and clinicopathological factors was developed to provide continuous biological risk assessment.
Yuzo Umeda, Toshiharu Mitsuhashi, Tomokazu Fuji, Toru Kojima, Takeshi Koujima, Tatsuo Matsuda, Daisuke Satoh, Masaru Inagaki, Kosei Takagi, Toshiyoshi Fujiwara   +9 more
wiley   +1 more source

Analysis of codon usage pattern in Taenia saginata based on a transcriptome dataset

Parasites & Vectors, 2014
Background Codon usage bias is an important evolutionary feature in a genome and has been widely documented in many genomes. Analysis of codon usage bias has significance for mRNA translation, design of transgenes, new gene discovery, and studies of ...
Xing Yang, Xuenong Luo, Xuepeng Cai
doaj   +1 more source

Quantitative relationship between synonymous codon usage bias and GC composition across unicellular genomes

BMC Evolutionary Biology, 2004
Background Codon usage bias has been widely reported to correlate with GC composition. However, the quantitative relationship between codon usage bias and GC composition across species has not been reported.
Kleinhofs Andris, Xu Dong, Wan Xiu-Feng, Zhou Jizhong   +3 more
doaj   +1 more source

The Selective Advantage of Synonymous Codon Usage Bias in Salmonella

PLOS Genetics, 2016
The genetic code in mRNA is redundant, with 61 sense codons translated into 20 different amino acids. Individual amino acids are encoded by up to six different codons but within codon families some are used more frequently than others. This phenomenon is referred to as synonymous codon usage bias.
Brandis, Gerrit, Hughes, Diarmaid
openaire   +5 more sources

Mapping evolutionary paradigm of Oropouche virus driven by dinucleotide bias and context-dependent codon bias

Virulence
Arthropod-borne viruses (arboviruses) pose significant public health threats, and understanding their evolutionary mechanisms can inform molecular diagnostics and vaccine design.
Xuanye Yang, Zeyu Liu, Xiaoting Ren, Chunlin Wang, Jianhua Zhou   +4 more
doaj   +1 more source

AR: An Artificial Intelligence‐Driven Fluorescent Reporter System for Gene Editing Evaluation

Animal Research and One Health, EarlyView.
The AR platform integrates an enhanced dual‐fluorescence reporter with the EasyReporter AI pipeline for efficient gene‐editing evaluation. It enables automated, high‐throughput quantification and intelligent interpretation across diverse gene‐editing systems and cellular contexts. The gene‐editing elements were created with BioGDP.com.
Mingming Xue, Hanhan Li, Yuwan Zheng, Hezhen Yang, Pengsheng Dong, Hang Jiao, Junhao Zhang, Genyuan Li, Ziyao Zhu, Hongjiang Li, Miao Zhang, Zhiquan Wang, Baosheng Feng, Qunting Lin, Guoying Hua, Kejun Wang, Wenting Li, Xiangtao Kang   +17 more
wiley   +1 more source

Next‐Generation Glutamine Synthetase Expression Vector for Therapeutic Protein Manufacturing Using CHO Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The glutamine synthetase expression system is widely used for therapeutic protein biomanufacturing in Chinese hamster ovary (CHO) cells. Here, we present the design of an enhanced glutamine synthetase vector for generating CHOK1SV GS‐KO stable pools that produce recombinant proteins at multigram‐per‐liter levels. We first developed a synthetic
Yusuf B. Johari, Sophie J. Wensley, Malak A. Ammar, Avinash Srivastava, Changhavi Ragurajan, Jenish Patel, Natalie C. Elliott, Alice C. Hodgson‐Casson, Mariano Olivera Fedi, Michael Anbar, Peter M. O'Callaghan, Bernie Sweeney   +11 more
wiley   +1 more source

Codon usage bias in the N gene of rabies virus

Infection, Genetics and Evolution, 2017
Since its emergence, rabies virus (RABV) has been a major worldwide concern especially in developing countries. The nucleoprotein (N) of RABV is highly conserved and key for genetic typing, thus a better understanding of the N gene evolutionary trajectory can assist the development of control measures.
Wanting, He, Hongyu, Zhang, Yuchen, Zhang, Ruyi, Wang, Sijia, Lu, Yanjie, Ji, Chang, Liu, Pengkun, Yuan, Shuo, Su   +8 more
openaire   +2 more sources