Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Factorial Structureand Psychometric Properties of Nadeau College-Level ADHD Questionnaire– thePersian Version [PDF]
Ravānshināsī-i Afrād-i Istis̠nāyī, 2014 The purpose of this studywas to investigateFactorial StructureandPsychometric Properties of NadeauCollege-level ADHD Questionnaire-thePersian Version for Iranian university students. 612 students were selected from the population of undergraduatestudents
fereshte baezat, ahmad ahmadi
doaj
On the Importance of Coefficient Alpha for Measurement Research: Loading Equality Is Not Necessary for Alpha's Utility as a Scale Reliability Index. [PDF]
Educ Psychol Meas, 2023 Raykov T, Anthony JC, Menold N.
europepmc +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Orthopaedic Journal of Sports MedicineBackground: Multiple prospective cohort studies have consistently shown a strong association between cam morphology and the development of hip osteoarthritis.
Delong Chen MD +6 more
doaj +1 more source
Performance of Coefficient Alpha and Its Alternatives: Effects of Different Types of Non-Normality. [PDF]
Educ Psychol Meas, 2023 Xiao L, Hau KT.
europepmc +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
The role of organizational culture on the commitment and commitment of human resources through mediation of talent management (Case study: Education in Tehran) [PDF]
پژوهش در نظامهای آموزشی, 2018 The present study was conducted to investigate the role of organizational culture on the commitment and commitment of human resources through talent management mediation.
Parinaz Banisi
doaj